Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Innate immunity based cancer immunotherapy: B16-F10 murine melanoma model

V. Caisová, A. Vieru, Z. Kumžáková, S. Glaserová, H. Husníková, N. Vácová, G. Krejčová, L. Paďouková, I. Jochmanová, KI. Wolf, J. Chmelař, J. Kopecký, J. Ženka,

. 2016 ; 16 (1) : 940. [pub] 20161207

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc17031239

BACKGROUND: Using killed microorganisms or their parts to stimulate immunity for cancer treatment dates back to the end of 19(th) century. Since then, it undergone considerable development. Our novel approach binds ligands to the tumor cell surface, which stimulates tumor phagocytosis. The therapeutic effect is further amplified by simultaneous application of agonists of Toll-like receptors. We searched for ligands that induce both a strong therapeutic effect and are safe for humans. METHODS: B16-F10 murine melanoma model was used. For the stimulation of phagocytosis, mannan or N-formyl-methionyl-leucyl-phenylalanine, was covalently bound to tumor cells or attached using hydrophobic anchor. The following agonists of Toll-like receptors were studied: monophosphoryl lipid A (MPLA), imiquimod (R-837), resiquimod (R-848), poly(I:C), and heat killed Listeria monocytogenes. RESULTS: R-848 proved to be the most suitable Toll-like receptor agonist for our novel immunotherapeutic approach. In combination with covalently bound mannan, R-848 significantly reduced tumor growth. Adding poly(I:C) and L. monocytogenes resulted in complete recovery in 83% of mice and in their protection from the re-transplantation of melanoma cells. CONCLUSION: An efficient cancer treatment results from the combination of Toll-like receptor agonists and phagocytosis stimulating ligands bound to the tumor cells.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc17031239
003      
CZ-PrNML
005      
20171025115440.0
007      
ta
008      
171025s2016 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12885-016-2982-x $2 doi
035    __
$a (PubMed)27927165
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Caisová, Veronika $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
245    10
$a Innate immunity based cancer immunotherapy: B16-F10 murine melanoma model / $c V. Caisová, A. Vieru, Z. Kumžáková, S. Glaserová, H. Husníková, N. Vácová, G. Krejčová, L. Paďouková, I. Jochmanová, KI. Wolf, J. Chmelař, J. Kopecký, J. Ženka,
520    9_
$a BACKGROUND: Using killed microorganisms or their parts to stimulate immunity for cancer treatment dates back to the end of 19(th) century. Since then, it undergone considerable development. Our novel approach binds ligands to the tumor cell surface, which stimulates tumor phagocytosis. The therapeutic effect is further amplified by simultaneous application of agonists of Toll-like receptors. We searched for ligands that induce both a strong therapeutic effect and are safe for humans. METHODS: B16-F10 murine melanoma model was used. For the stimulation of phagocytosis, mannan or N-formyl-methionyl-leucyl-phenylalanine, was covalently bound to tumor cells or attached using hydrophobic anchor. The following agonists of Toll-like receptors were studied: monophosphoryl lipid A (MPLA), imiquimod (R-837), resiquimod (R-848), poly(I:C), and heat killed Listeria monocytogenes. RESULTS: R-848 proved to be the most suitable Toll-like receptor agonist for our novel immunotherapeutic approach. In combination with covalently bound mannan, R-848 significantly reduced tumor growth. Adding poly(I:C) and L. monocytogenes resulted in complete recovery in 83% of mice and in their protection from the re-transplantation of melanoma cells. CONCLUSION: An efficient cancer treatment results from the combination of Toll-like receptor agonists and phagocytosis stimulating ligands bound to the tumor cells.
650    _2
$a zvířata $7 D000818
650    _2
$a cytokiny $x metabolismus $7 D016207
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a imidazoly $x farmakologie $7 D007093
650    12
$a přirozená imunita $7 D007113
650    12
$a imunoterapie $x metody $7 D007167
650    _2
$a ligandy $7 D008024
650    _2
$a mannany $x imunologie $7 D008351
650    _2
$a melanom experimentální $7 D008546
650    _2
$a myši $7 D051379
650    _2
$a nádory $x imunologie $x metabolismus $x patologie $x terapie $7 D009369
650    _2
$a infiltrace neutrofily $x imunologie $7 D020556
650    _2
$a neutrofily $x imunologie $x metabolismus $7 D009504
650    _2
$a fagocytóza $7 D010587
650    _2
$a poly I-C $x imunologie $7 D011070
650    _2
$a respirační vzplanutí $x imunologie $7 D016897
650    _2
$a toll-like receptory $x agonisté $x metabolismus $7 D051193
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vieru, Andra $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
700    1_
$a Kumžáková, Zuzana $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
700    1_
$a Glaserová, Simona $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
700    1_
$a Husníková, Hana $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
700    1_
$a Vácová, Nikol $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
700    1_
$a Krejčová, Gabriela $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
700    1_
$a Paďouková, Lucie $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
700    1_
$a Jochmanová, Ivana $u 1st Department of Internal Medicine, Medical Faculty of P. J. Šafárik University in Košice, Košice, Slovakia.
700    1_
$a Wolf, Katherine I $u University of Michigan Medical Center, Ann Arbor, MI, USA.
700    1_
$a Chmelař, Jindřich $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic.
700    1_
$a Kopecký, Jan $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic. Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, v.v.i., České Budějovice, Czech Republic.
700    1_
$a Ženka, Jan $u Department of Medical Biology, Faculty of Science, University of South Bohemia, České Budějovice, Czech Republic. jzenka@gmail.com.
773    0_
$w MED00008171 $t BMC cancer $x 1471-2407 $g Roč. 16, č. 1 (2016), s. 940
856    41
$u https://pubmed.ncbi.nlm.nih.gov/27927165 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20171025 $b ABA008
991    __
$a 20171025115522 $b ABA008
999    __
$a ok $b bmc $g 1254832 $s 992266
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2016 $b 16 $c 1 $d 940 $e 20161207 $i 1471-2407 $m BMC cancer $n BMC Cancer $x MED00008171
LZP    __
$a Pubmed-20171025

Najít záznam

Citační ukazatele

Možnosti archivace