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Cortical miscommunication after prenatal exposure to alcohol
SM. Lewis, RR. Vydrová, AC. Leuthold, AP. Georgopoulos,
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články
NLK
ProQuest Central
od 2001-01-01 do 2017-12-31
Medline Complete (EBSCOhost)
od 2000-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2001-01-01 do 2017-12-31
Health & Medicine (ProQuest)
od 2001-01-01 do 2017-12-31
Psychology Database (ProQuest)
od 2001-01-01 do 2017-12-31
- MeSH
- alkoholy škodlivé účinky MeSH
- analýza rozptylu MeSH
- časové faktory MeSH
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- magnetoencefalografie MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mozková kůra patofyziologie MeSH
- neurovývojové poruchy etiologie MeSH
- spektrum vrozených alkoholových poruch etiologie MeSH
- studie případů a kontrol MeSH
- těhotenství MeSH
- zpožděný efekt prenatální expozice patologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
We report on the effects of prenatal alcohol exposure on resting-state brain activity as measured by magnetoencephalography (MEG). We studied 37 subjects diagnosed with fetal alcohol spectrum disorder in one of three categories: fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder. For each subject, the MEG signal was recorded for 60 s during rest while subjects lay supine. Using time series analysis, we calculated the synchronous neural interactions for all pair-wise combinations of 248 MEG sensors resulting in 30,628 partial correlations for each subject. We found significant differences from control subjects in 6.19 % of the partial zero-lag crosscorrelations (synchronous neural interactions; Georgopoulos et al. in J Neural Eng 4:349-355, 2007), with these differences localized in the right posterior frontal, right parietal, and left parietal/posterior frontal regions. These results show that MEG can detect functional brain differences in the individuals affected by prenatal exposure to alcohol. Furthermore, these differences may serve as a biomarker for future studies linking symptoms and signs to specific brain areas. This may lead to new insights into the neuropathology of fetal alcohol spectrum disorders.
Citace poskytuje Crossref.org
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- $a Lewis, Scott M $u Brain Sciences Center (11B), Minneapolis VA Health Care System, One Veterans Drive, Minneapolis, MN, 55417, USA. lewis093@umn.edu. Department of Neurology, University of Minnesota, Minneapolis, MN, 55455, USA. lewis093@umn.edu.
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- $a We report on the effects of prenatal alcohol exposure on resting-state brain activity as measured by magnetoencephalography (MEG). We studied 37 subjects diagnosed with fetal alcohol spectrum disorder in one of three categories: fetal alcohol syndrome, partial fetal alcohol syndrome, and alcohol-related neurodevelopmental disorder. For each subject, the MEG signal was recorded for 60 s during rest while subjects lay supine. Using time series analysis, we calculated the synchronous neural interactions for all pair-wise combinations of 248 MEG sensors resulting in 30,628 partial correlations for each subject. We found significant differences from control subjects in 6.19 % of the partial zero-lag crosscorrelations (synchronous neural interactions; Georgopoulos et al. in J Neural Eng 4:349-355, 2007), with these differences localized in the right posterior frontal, right parietal, and left parietal/posterior frontal regions. These results show that MEG can detect functional brain differences in the individuals affected by prenatal exposure to alcohol. Furthermore, these differences may serve as a biomarker for future studies linking symptoms and signs to specific brain areas. This may lead to new insights into the neuropathology of fetal alcohol spectrum disorders.
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