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Comparison of MicroRNA Content in Plasma and Urine Indicates the Existence of a Transrenal Passage of Selected MicroRNAs
E. Pazourkova, S. Pospisilova, I. Svobodova, A. Horinek, A. Brisuda, V. Soukup, J. Hrbacek, O. Capoun, J. Mares, T. Hanus, M. Babjuk, M. Korabecna,
Advances in experimental medicine and biology.
2016 ;
924 (-) :
97-100.
Jazyk angličtina Země Spojené státy americké
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc17031377
- MeSH
- dospělí MeSH
- ledviny metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikro RNA krev genetika moč MeSH
- mladý dospělý MeSH
- nádorové biomarkery krev genetika moč MeSH
- nádory močového měchýře diagnóza genetika MeSH
- polymerázová řetězová reakce s reverzní transkripcí MeSH
- regulace genové exprese u nádorů MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
MicroRNAs (miRNAs) in urine are examined as potential biomarkers. We examined the urine samples from 70 individuals (45 males, 25 females, mean age 65 years, range 20-84 years). Of the urine donors, 15 were healthy volunteers, 5 were patients with non-cancer diseases, 50 were patients with different stages of bladder cancer. To examine the spectrum of miRNAs in the cell-free fraction of urine, TaqMan Human miRNA Array Card A v.2.1 was used. A set of 30 miRNAs were found that are constantly present in urine supernatants independently of sex, age and health status of the subjects. We compared this set with miRNAs found in plasma, expressed in kidney and genito-urinary tract. Our results indicate that some miRNA could be transferred from the circulation into urine.
Citace poskytuje Crossref.org
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- $a Pazourkova, Eva $u Department of Nephrology, First Faculty of Medicine, Charles University and General Faculty Hospital in Prague, Prague, Czech Republic.
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- $a MicroRNAs (miRNAs) in urine are examined as potential biomarkers. We examined the urine samples from 70 individuals (45 males, 25 females, mean age 65 years, range 20-84 years). Of the urine donors, 15 were healthy volunteers, 5 were patients with non-cancer diseases, 50 were patients with different stages of bladder cancer. To examine the spectrum of miRNAs in the cell-free fraction of urine, TaqMan Human miRNA Array Card A v.2.1 was used. A set of 30 miRNAs were found that are constantly present in urine supernatants independently of sex, age and health status of the subjects. We compared this set with miRNAs found in plasma, expressed in kidney and genito-urinary tract. Our results indicate that some miRNA could be transferred from the circulation into urine.
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- $a Pospisilova, Sarka $u Department of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General Faculty Hospital in Prague, Prague, Czech Republic.
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- $a Brisuda, Antonin $u Department of Urology, 2nd Faculty of Medicine, Charles University and University Hospital Motol in Prague, Prague, Czech Republic.
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- $a Korabecna, Marie $u Department of Biology and Medical Genetics, First Faculty of Medicine, Charles University and General Faculty Hospital in Prague, Prague, Czech Republic. marie.korabecna@lf1.cuni.cz.
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