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Synthesis of a Small Library of Imidazolidin-2-ones using Gold Catalysis on Solid Phase
A. La-Venia, NS. Medran, V. Krchňák, SA. Testero,
ACS combinatorial science.
2016 ;
18 (8) :
482-9.
[pub] 20160708
Language English Country United States
Document type Journal Article
Persistent link
https://www.medvik.cz/link/bmc17031635
- MeSH
- Alkynes chemistry MeSH
- Cyclization MeSH
- Imidazolidines chemical synthesis MeSH
- Catalysis MeSH
- Small Molecule Libraries chemical synthesis MeSH
- Molecular Structure MeSH
- Combinatorial Chemistry Techniques MeSH
- Solid-Phase Synthesis Techniques MeSH
- Gold chemistry MeSH
- Publication type
- Journal Article MeSH
An efficient and high-yielding solid phase synthesis of a small library of imidazolidin-2-ones and imidazol-2-ones was carried out employing a high chemo- and regioselective gold-catalyzed cycloisomerization as a key step. Polymer-supported amino acids derivatized with several alkyne functionalities combined with tosyl- and phenylureas have been subjected to gold-catalysis exhibiting exclusively C-N bond formation. The present work proves the potential of solid phase synthesis and homogeneous gold catalysis as an efficient and powerful synthetic tool for the generation of drug-like heterocycles.
References provided by Crossref.org
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- $a An efficient and high-yielding solid phase synthesis of a small library of imidazolidin-2-ones and imidazol-2-ones was carried out employing a high chemo- and regioselective gold-catalyzed cycloisomerization as a key step. Polymer-supported amino acids derivatized with several alkyne functionalities combined with tosyl- and phenylureas have been subjected to gold-catalysis exhibiting exclusively C-N bond formation. The present work proves the potential of solid phase synthesis and homogeneous gold catalysis as an efficient and powerful synthetic tool for the generation of drug-like heterocycles.
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