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Dosimetry-based treatment planning for molecular radiotherapy: a summary of the 2017 report from the Internal Dosimetry Task Force

C. Stokke, PM. Gabiña, P. Solný, F. Cicone, M. Sandström, KS. Gleisner, C. Chiesa, E. Spezi, M. Paphiti, M. Konijnenberg, M. Aldridge, J. Tipping, M. Wissmeyer, B. Brans, K. Bacher, C. Kobe, G. Flux,

. 2017 ; 4 (1) : 27. [pub] 20171121

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18000931

BACKGROUND: The European directive on basic safety standards (Council directive 2013/59 Euratom) mandates dosimetry-based treatment planning for radiopharmaceutical therapies. The directive comes into operation February 2018, and the aim of a report produced by the Internal Dosimetry Task Force of the European Association of Nuclear Medicine is to address this aspect of the directive. A summary of the report is presented. RESULTS: A brief review of five of the most common therapy procedures is included in the current text, focused on the potential to perform patient-specific dosimetry. In the full report, 11 different therapeutic procedures are included, allowing additional considerations of effectiveness, references to specific literature on quantitative imaging and dosimetry, and existing evidence for absorbed dose-effect correlations for each treatment. Individualized treatment planning with tracer diagnostics and verification of the absorbed doses delivered following therapy is found to be scientifically feasible for almost all procedures investigated, using quantitative imaging and/or external monitoring. Translation of this directive into clinical practice will have significant implications for resource requirements. CONCLUSIONS: Molecular radiotherapy is undergoing a significant expansion, and the groundwork for dosimetry-based treatment planning is already in place. The mandated individualization is likely to improve the effectiveness of the treatments, although must be adequately resourced.

Department for Nuclear Medicine University Hospital of Cologne Cologne Germany

Department of Basic Medical Sciences Division of Medical Physics Ghent University Ghent Belgium

Department of Diagnostic Physics Oslo University Hospital Oslo Norway

Department of Dosimetry and Application of Ionizing Radiation Czech Technical University Prague Prague Czech Republic

Department of Medical Physics and Radiation Protection Gurutzeta Cruces University Hospital Barakaldo Spain

Department of Medical Physics Pammakaristos Hospital Athens Greece

Department of Medical Radiation Physics Clinical Sciences Lund Lund University Lund Sweden

Department of Nuclear Medicine and PET Center University Hospital Ghent Belgium

Department of Nuclear Medicine University Hospital of Geneva Geneva Switzerland

Department of Radiology and Nuclear Medicine Erasmus MC Rotterdam The Netherlands

Joint Department of Physics Royal Marsden Hospital and Institute of Cancer Research Sutton UK

Nuclear Medicine Division Foundation IRCCS istituto nazionale Tumori Milan Italy

Nuclear Medicine Radiotherapy Physics UCL Institute of Nuclear Medicine and UCL Hospitals NHS Foundation Trust London UK

Nuclear Medicine Sant'Andrea Hospital Department of Surgical and Medical Sciences and Translational Medicine Sapienza University of Rome Rome Italy

School of Engineering Cardiff University Cardiff UK

Section of Nuclear Medicine and PET Department of Surgical Sciences Uppsala University Uppsala Sweden

The Christie NHS Foundation Trust Nuclear Medicine Manchester UK

Citace poskytuje Crossref.org

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$a Gabiña, Pablo Minguez $u Department of Medical Physics and Radiation Protection, Gurutzeta/Cruces University Hospital, Barakaldo, Spain.
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$a Kobe, Carsten $u Department for Nuclear Medicine, University Hospital of Cologne, Cologne, Germany.
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