-
Je něco špatně v tomto záznamu ?
Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract
M. Nordlund, M. Belka, AK. Kuczaj, F. Lizal, J. Jedelsky, J. Elcner, M. Jicha, Y. Sauser, S. Le Bouhellec, S. Cosandey, S. Majeed, G. Vuillaume, MC. Peitsch, J. Hoeng,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- aerosoly farmakokinetika MeSH
- anatomické modely * MeSH
- aplikace inhalační MeSH
- dýchací soustava metabolismus MeSH
- glycerol farmakokinetika MeSH
- lidé MeSH
- velikost částic MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Inhalation of aerosols generated by electronic cigarettes leads to deposition of multiple chemical compounds in the human airways. In this work, an experimental method to determine regional deposition of multicomponent aerosols in an in vitro segmented, realistic human lung geometry was developed and applied to two aerosols, i.e. a monodisperse glycerol aerosol and a multicomponent aerosol. The method comprised the following steps: (1) lung cast model preparation, (2) aerosol generation and exposure, (3) extraction of deposited mass, (4) chemical quantification and (5) data processing. The method showed good agreement with literature data for the deposition efficiency when using a monodisperse glycerol aerosol, with a mass median aerodynamic diameter (MMAD) of 2.3 μm and a constant flow rate of 15 L/min. The highest deposition surface density rate was observed in the bifurcation segments, indicating inertial impaction deposition. The experimental method was also applied to the deposition of a nebulized multicomponent aerosol with a MMAD of 0.50 μm and a constant flow rate of 15 L/min. The deposited amounts of glycerol, propylene glycol and nicotine were quantified. The three analyzed compounds showed similar deposition patterns and fractions as for the monodisperse glycerol aerosol, indicating that the compounds most likely deposited as parts of the same droplets. The developed method can be used to determine regional deposition for multicomponent aerosols, provided that the compounds are of low volatility. The generated data can be used to validate aerosol deposition simulations and to gain insight in deposition of electronic cigarette aerosols in human airways.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18010605
- 003
- CZ-PrNML
- 005
- 20180416100414.0
- 007
- ta
- 008
- 180404s2017 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1080/08958378.2017.1315196 $2 doi
- 035 __
- $a (PubMed)28470142
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Nordlund, Markus $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland.
- 245 10
- $a Multicomponent aerosol particle deposition in a realistic cast of the human upper respiratory tract / $c M. Nordlund, M. Belka, AK. Kuczaj, F. Lizal, J. Jedelsky, J. Elcner, M. Jicha, Y. Sauser, S. Le Bouhellec, S. Cosandey, S. Majeed, G. Vuillaume, MC. Peitsch, J. Hoeng,
- 520 9_
- $a Inhalation of aerosols generated by electronic cigarettes leads to deposition of multiple chemical compounds in the human airways. In this work, an experimental method to determine regional deposition of multicomponent aerosols in an in vitro segmented, realistic human lung geometry was developed and applied to two aerosols, i.e. a monodisperse glycerol aerosol and a multicomponent aerosol. The method comprised the following steps: (1) lung cast model preparation, (2) aerosol generation and exposure, (3) extraction of deposited mass, (4) chemical quantification and (5) data processing. The method showed good agreement with literature data for the deposition efficiency when using a monodisperse glycerol aerosol, with a mass median aerodynamic diameter (MMAD) of 2.3 μm and a constant flow rate of 15 L/min. The highest deposition surface density rate was observed in the bifurcation segments, indicating inertial impaction deposition. The experimental method was also applied to the deposition of a nebulized multicomponent aerosol with a MMAD of 0.50 μm and a constant flow rate of 15 L/min. The deposited amounts of glycerol, propylene glycol and nicotine were quantified. The three analyzed compounds showed similar deposition patterns and fractions as for the monodisperse glycerol aerosol, indicating that the compounds most likely deposited as parts of the same droplets. The developed method can be used to determine regional deposition for multicomponent aerosols, provided that the compounds are of low volatility. The generated data can be used to validate aerosol deposition simulations and to gain insight in deposition of electronic cigarette aerosols in human airways.
- 650 _2
- $a aplikace inhalační $7 D000280
- 650 _2
- $a aerosoly $x farmakokinetika $7 D000336
- 650 _2
- $a glycerol $x farmakokinetika $7 D005990
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a anatomické modely $7 D008953
- 650 _2
- $a velikost částic $7 D010316
- 650 _2
- $a dýchací soustava $x metabolismus $7 D012137
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Belka, Miloslav $u b Energy Institute, Faculty of Mechanical Engineering , Brno University of Technology , Brno , Czech Republic.
- 700 1_
- $a Kuczaj, Arkadiusz K $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland. c Department of Applied Mathematics , University of Twente , Enschede , The Netherlands.
- 700 1_
- $a Lizal, Frantisek $u b Energy Institute, Faculty of Mechanical Engineering , Brno University of Technology , Brno , Czech Republic.
- 700 1_
- $a Jedelsky, Jan $u b Energy Institute, Faculty of Mechanical Engineering , Brno University of Technology , Brno , Czech Republic.
- 700 1_
- $a Elcner, Jakub $u b Energy Institute, Faculty of Mechanical Engineering , Brno University of Technology , Brno , Czech Republic.
- 700 1_
- $a Jicha, Miroslav $u b Energy Institute, Faculty of Mechanical Engineering , Brno University of Technology , Brno , Czech Republic.
- 700 1_
- $a Sauser, Youri $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland.
- 700 1_
- $a Le Bouhellec, Soazig $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland.
- 700 1_
- $a Cosandey, Stephane $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland.
- 700 1_
- $a Majeed, Shoaib $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland.
- 700 1_
- $a Vuillaume, Grégory $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland.
- 700 1_
- $a Peitsch, Manuel C $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland.
- 700 1_
- $a Hoeng, Julia $u a Philip Morris International Research & Development, Philip Morris Products S.A. , Neuchâtel , Switzerland.
- 773 0_
- $w MED00007248 $t Inhalation toxicology $x 1091-7691 $g Roč. 29, č. 3 (2017), s. 113-125
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/28470142 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20180404 $b ABA008
- 991 __
- $a 20180416100511 $b ABA008
- 999 __
- $a ok $b bmc $g 1288090 $s 1007417
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2017 $b 29 $c 3 $d 113-125 $i 1091-7691 $m Inhalation toxicology $n Inhal Toxicol $x MED00007248
- LZP __
- $a Pubmed-20180404
