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Hints on the Lateralization of Dopamine Binding to D1 Receptors in Rat Striatum
R. Franco, V. Casadó-Anguera, A. Muñoz, M. Petrovic, G. Navarro, E. Moreno, JL. Lanciego, JL. Labandeira-García, A. Cortés, V. Casadó,
Molecular neurobiology.
2016 ;
53 (8) :
5436-45.
[pub] 20151009
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
Persistent link
https://www.medvik.cz/link/bmc18011336
Online
Full text
NLK
ProQuest Central
from 1997-02-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2010-02-01 to 1 year ago
Health & Medicine (ProQuest)
from 1997-02-01 to 1 year ago
Psychology Database (ProQuest)
from 1997-02-01 to 1 year ago
- MeSH
- 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine pharmacology MeSH
- Benzazepines pharmacology MeSH
- Corpus Striatum metabolism MeSH
- Dopamine metabolism MeSH
- Functional Laterality * drug effects MeSH
- Dyskinesia, Drug-Induced metabolism MeSH
- Rats, Wistar MeSH
- Receptors, Dopamine D1 metabolism MeSH
- Receptors, Dopamine D3 agonists metabolism MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Dopamine receptors in striatum are important for healthy brain functioning and are the target of levodopa-based therapy in Parkinson's disease. Lateralization of dopaminergic neurotransmission in striata from different hemispheres occurs in patients, but also in healthy individuals. Our data show that the affinity of dopamine binding to dopamine D1 receptors is significantly higher in left than in right striatum. Analysis of data from radioligand binding to striatal samples from naïve, 6-hydroxydopamine lesioned, levodopa-treated and levodopa-induced dyskinetic rats shows differential receptor structure and gives hints on the causes of right/left lateralization of dopamine binding to striatal D1 receptors. Moreover, binding data showed loss of lateralization in levodopa (L-DOPA)-induced dyskinetic rats.
References provided by Crossref.org
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