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Cooling-evoked hemodynamic perturbations facilitate sympathetic activity with subsequent myogenic vascular oscillations via alpha2-adrenergic receptors
Y. H. Lin, Y. P. Liu, Y. C. Lin, P. L. Lee, C. S. Tung
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Free Medical Journals od 1998
ProQuest Central od 2005-01-01
Medline Complete (EBSCOhost) od 2006-01-01
Nursing & Allied Health Database (ProQuest) od 2005-01-01
Health & Medicine (ProQuest) od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources od 1998
Odkazy
PubMed
28248541
DOI
10.33549/physiolres.933385
Knihovny.cz E-zdroje
- MeSH
- alfa-2-adrenergní receptory - antagonisté farmakologie MeSH
- alfa-2-adrenergní receptory fyziologie MeSH
- hemodynamika účinky léků fyziologie MeSH
- krevní tlak účinky léků fyziologie MeSH
- krysa rodu rattus MeSH
- náhodné rozdělení MeSH
- nízká teplota škodlivé účinky MeSH
- potkani Sprague-Dawley MeSH
- srdeční frekvence účinky léků fyziologie MeSH
- telemetrie metody MeSH
- vazokonstrikce účinky léků fyziologie MeSH
- yohimbin farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
This study extends our previous work by examining the effects of alpha2-adrenoceptors under cold stimulation involving the increase of myogenic vascular oscillations as increases of very-low-frequency and low-frequency of the blood pressure variability. Forty-eight adult male Sprague-Dawley rats were randomly divided into four groups: vehicle; yohimbine; hexamethonium+yohimbine; guanethidine+yohimbine. Systolic blood pressure, heart rate, power spectral analysis of spontaneous blood pressure and heart rate variability and spectral coherence at very-low-frequency (0.02 to 0.2 Hz), low-frequency (0.2 to 0.6 Hz), and high-frequency (0.6 to 3.0 Hz) regions were monitored using telemetry. Key findings are as follows: 1) Cooling-induced pressor response was attenuated by yohimbine and further attenuated by hexamethonium+yohimbine and guanethidine+yohimbine, 2) Cooling-induced tachycardia response of yohimbine was attenuated by hexamethonium+yohimbine and guanethidine+yohimbine, 3) Different patterns of power spectrum reaction and coherence value compared hexamethonium+yohimbine and guanethidine+yohimbine to yohimbine alone under cold stimulation. The results suggest that sympathetic activation of the postsynaptic alpha2-adrenoceptors causes vasoconstriction and heightening myogenic vascular oscillations, in turn, may increase blood flow to prevent tissue damage under stressful cooling challenge.
Department of Electrical Engineering National Central University Taoyuan Taiwan
Department of Physiology National Defense Medical Center Taipei Taiwan
Division of Medical Research and Education Cheng Hsin General Hospital Beitou Taipei Taiwan
School of Medicine National Yang Ming University Taipei Taiwan
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