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High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans
A. Roy, V. Bystry, G. Bohn, K. Goudevenou, T. Reigl, M. Papaioannou, A. Krejci, S. O'Byrne, A. Chaidos, A. Grioni, N. Darzentas, IAG. Roberts, A. Karadimitris,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NV16-34272A
MZ0
CEP - Centrální evidence projektů
- MeSH
- B-lymfocyty imunologie MeSH
- chronická lymfatická leukemie genetika imunologie MeSH
- imunoglobulin M genetika imunologie MeSH
- játra imunologie MeSH
- kostní dřeň imunologie MeSH
- lidé MeSH
- lymfopoéza genetika imunologie MeSH
- plod imunologie MeSH
- receptory antigenů B-buněk genetika imunologie MeSH
- sekvenční analýza DNA MeSH
- těžké řetězce imunoglobulinů genetika imunologie MeSH
- vysoce účinné nukleotidové sekvenování MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consistent with persisting fetal IgM+ B cells being a source of natural IgM repertoire in adult life. Further, the origins of specific stereotypic IgM+ B cell receptors associated with chronic lymphocytic leukemia, can be traced back to fetal B cell lymphopoiesis, suggesting that persisting fetal B cells can be subject to malignant transformation late in life. Overall, these novel data provide unique insights into the ontogeny of physiological and malignant B lymphopoiesis that spans the human lifetime.
CEITEC Central European Institute of Technology Masaryk University Brno Czech Republic
Department of Paediatrics University of Oxford Brno Czech Republic
RECAMO Masaryk Memorial Cancer Institute Brno Czech Republic
Citace poskytuje Crossref.org
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- $a Roy, Anindita $u Department of Paediatrics, University of Oxford, Brno, Czech Republic.
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- $a High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans / $c A. Roy, V. Bystry, G. Bohn, K. Goudevenou, T. Reigl, M. Papaioannou, A. Krejci, S. O'Byrne, A. Chaidos, A. Grioni, N. Darzentas, IAG. Roberts, A. Karadimitris,
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- $a The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consistent with persisting fetal IgM+ B cells being a source of natural IgM repertoire in adult life. Further, the origins of specific stereotypic IgM+ B cell receptors associated with chronic lymphocytic leukemia, can be traced back to fetal B cell lymphopoiesis, suggesting that persisting fetal B cells can be subject to malignant transformation late in life. Overall, these novel data provide unique insights into the ontogeny of physiological and malignant B lymphopoiesis that spans the human lifetime.
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