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Nonenzymatic Oligomerization of 3',5'-Cyclic CMP Induced by Proton and UV Irradiation Hints at a Nonfastidious Origin of RNA

G. Costanzo, A. Giorgi, A. Scipioni, AM. Timperio, C. Mancone, M. Tripodi, M. Kapralov, E. Krasavin, H. Kruse, J. Šponer, JE. Šponer, V. Ranc, M. Otyepka, S. Pino, E. Di Mauro,

. 2017 ; 18 (15) : 1535-1543. [pub] 20170630

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc18016626

We report that 3',5'-cyclic CMP undergoes nonenzymatic di- and trimerization at 20 °C under dry conditions upon proton or UV irradiation. The reaction involves stacking of the cyclic monomers and subsequent polymerization through serial transphosphorylations between the stacked monomers. Proton- and UV-induced oligomerization of 3',5'-cyclic CMP demonstrates that pyrimidines-similar to purines-might also have taken part in the spontaneous generation of RNA under plausible prebiotic conditions as well as in an extraterrestrial context. The observed polymerization of naturally occurring 3',5'-cyclic nucleotides supports the possibility that the extant genetic nucleic acids might have originated by way of a straight Occamian path, starting from simple reactions between plausibly preactivated monomers.

Citace poskytuje Crossref.org

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$a Costanzo, Giovanna $u Istituto di Biologia e Patologia Molecolari, CNR, Piazzale Aldo Moro 5, 00185, Rome, Italy.
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$a We report that 3',5'-cyclic CMP undergoes nonenzymatic di- and trimerization at 20 °C under dry conditions upon proton or UV irradiation. The reaction involves stacking of the cyclic monomers and subsequent polymerization through serial transphosphorylations between the stacked monomers. Proton- and UV-induced oligomerization of 3',5'-cyclic CMP demonstrates that pyrimidines-similar to purines-might also have taken part in the spontaneous generation of RNA under plausible prebiotic conditions as well as in an extraterrestrial context. The observed polymerization of naturally occurring 3',5'-cyclic nucleotides supports the possibility that the extant genetic nucleic acids might have originated by way of a straight Occamian path, starting from simple reactions between plausibly preactivated monomers.
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$a Giorgi, Alessandra $u Dipartimento di Scienze Biochimiche, "Sapienza" Università di Roma, Piazzale Aldo Moro 5, 00185, Rome, Italy.
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$a Scipioni, Anita $u Dipartimento di Chimica, "Sapienza" Università di Roma, Piazzale Aldo Moro 5, 00185, Rome, Italy.
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$a Timperio, Anna Maria $u Department of Ecology and Biology, "La Tuscia" University, Viale dell'Università snc, 01100, Viterbo, Italy.
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$a Mancone, Carmine $u Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Via Regina Elena 324, 00161, Roma, Italy. National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Via Portuense 292, 00149, Rome, Italy.
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$a Tripodi, Marco $u Department of Cellular Biotechnologies and Hematology, Sapienza University of Rome, Via Regina Elena 324, 00161, Roma, Italy. National Institute for Infectious Diseases "L. Spallanzani", IRCCS, Via Portuense 292, 00149, Rome, Italy.
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$a Kapralov, Michail $u Joint Institute for Nuclear Research, Laboratory of Radiation Biology, 141980, Dubna, Russia.
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$a Krasavin, Eugene $u Joint Institute for Nuclear Research, Laboratory of Radiation Biology, 141980, Dubna, Russia.
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$a Kruse, Holger $u Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265, Brno, Czech Republic.
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$a Šponer, Jiří $u Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265, Brno, Czech Republic. Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, 17. Listopadu, 771 46, Olomouc, Czech Republic.
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$a Šponer, Judit E $u Institute of Biophysics, Academy of Sciences of the Czech Republic, Královopolská 135, 61265, Brno, Czech Republic.
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$a Ranc, Václav $u Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacky University, 17. Listopadu, 771 46, Olomouc, Czech Republic.
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$a Pino, Samanta $u Department of Biology and Biotechnology, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
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$a Di Mauro, Ernesto $u Department of Biology and Biotechnology, Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.
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