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Impact of GM1 on Membrane-Mediated Aggregation/Oligomerization of β-Amyloid: Unifying View
M. Cebecauer, M. Hof, M. Amaro,
Language English Country United States
Document type Journal Article, Review
NLK
Cell Press Free Archives
from 1960-01-01 to 1 year ago
Free Medical Journals
from 1960 to 1 year ago
Freely Accessible Science Journals
from 1960 to 12 months ago
PubMed Central
from 1960 to 1 year ago
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from 1960 to 1 year ago
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from 1960-09-01
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from 1960-09-01 to 2018-02-06
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from 1960-09-01 to 1 year ago
- MeSH
- Amyloid beta-Peptides chemistry metabolism MeSH
- G(M1) Ganglioside chemistry metabolism MeSH
- Humans MeSH
- Brain metabolism MeSH
- Protein Aggregation, Pathological metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
In this perspective we summarize current knowledge of the effect of monosialoganglioside GM1 on the membrane-mediated aggregation of the β-amyloid (Aβ) peptide. GM1 has been suggested to be actively involved in the development of Alzheimer's disease due to its ability to seed the aggregation of Aβ. However, GM1 is known to be neuroprotective against Aβ-induced toxicity. Here we suggest that the two scenarios are not mutually exclusive but rather complementary, and might depend on the organization of GM1 in membranes. Improving our understanding of the molecular details behind the role of gangliosides in neurodegenerative amyloidoses might help in developing disease-modifying treatments.
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