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Effect of pramipexole alginate nanodispersion (PAND) on the transgenic Drosophila expressing human alpha synuclein in the brain
Yasir Hasan Siddique, Falaq Naz, Wasi Khan, Smita Jyoti, Braj Raj Singh, Alim Hussain Naqvi
Language English Country Czech Republic
- MeSH
- Dopamine Agonists adverse effects therapeutic use MeSH
- alpha-Synuclein * MeSH
- Drosophila melanogaster * MeSH
- Animals, Genetically Modified MeSH
- Oxidative Stress drug effects MeSH
- Parkinson Disease * drug therapy pathology MeSH
- Parkinsonian Disorders drug therapy MeSH
- Pramipexole MeSH
- Spectrophotometry, Infrared MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
In the present study the effect of pramipexole alginate nanodispersion (PAND) was studied on the transgenic Drosophila exhibiting the PD symptoms. The PD flies were allowed to feed on the diet having PAND at final concentration of 1, 2 and 3 μM. A dose dependent significant delay in the loss of climbing ability and improvement in the activity was observed in PD flies. A dose dependent significant change in the oxidative stress markers and dopamine content was also observed in the PD flies exposed to various doses PAND. The improvement in the PD symptoms was more in PD flies exposed to PAND compared to PD flies exposed to pramipexole alone.
Aligarh Muslim University Faculty of Science Department of Physics Aligarh India
Aligarh Muslim University Interdisciplinary Nanotechnology Centre Aligarh India
References provided by Crossref.org
Literatura
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- $a In the present study the effect of pramipexole alginate nanodispersion (PAND) was studied on the transgenic Drosophila exhibiting the PD symptoms. The PD flies were allowed to feed on the diet having PAND at final concentration of 1, 2 and 3 μM. A dose dependent significant delay in the loss of climbing ability and improvement in the activity was observed in PD flies. A dose dependent significant change in the oxidative stress markers and dopamine content was also observed in the PD flies exposed to various doses PAND. The improvement in the PD symptoms was more in PD flies exposed to PAND compared to PD flies exposed to pramipexole alone.
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