Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Influenza and pneumococcal vaccination in older adults living in nursing home: a survival analysis on the shelter study

A. Poscia, A. Collamati, A. Carfì, E. Topinkova, T. Richter, M. Denkinger, R. Pastorino, F. Landi, W. Ricciardi, R. Bernabei, G. Onder,

. 2017 ; 27 (6) : 1016-1020.

Language English Country England, Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc18024533

Background: Influenza and pneumococcal vaccines have been proved to be effective and safe in preventing and controlling infection among elderly, reducing morbidity and mortality. However, some evidences raised health concerns related to these vaccinations. This study aims to identify prevalence and outcomes related to influenza and pneumococcal vaccinations in a large European population of frail old people living in nursing homes (NHs). Methods: We conducted a survival analysis of NH residents participating to the Services and Health for Elderly in Long-TERm project, a prospective cohort study collecting information on residents admitted to 57 NH in eight countries (Czech Republic, England, Finland, France, Germany, Italy, The Netherlands and Israel). Clinical and demographical data were collected using the international resident assessement instrument for long-term care facilities. Incident mortality was recorded during 1-year follow-up. A shared-frailty Cox regression model was used to assess the impact of vaccination status on mortality. Results: Mean age of 3510 participants was 84.6 years (SD = 7.7). In total, 81.7 and 27.0% received influenza and pneumococcal vaccination, respectively. Overall, 727 (20.7%) residents died during the follow-up period. After adjusting for potential confounders, which included age, sex, number of diseases, depression, cognitive and functional status, influenza (HR = 0.80; 95% CI 0.66-0.97) and the combination of influenza and pneumococcal vaccination (HR = 0.72; 95% CI 0.57-0.91), but not pneumococcal vaccination alone (HR = 0.52; 95% CI 0.25-1.06), were associated with a statistically significant reduction in mortality in respect of no vaccinations. Conclusion: In a population of older adult living in NH influenza and the combination of influenza and pneumococcal vaccination were associated with a reduction in all-cause mortality respect to no vaccination.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18024533
003      
CZ-PrNML
005      
20180713114329.0
007      
ta
008      
180709s2017 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1093/eurpub/ckx150 $2 doi
035    __
$a (PubMed)29069321
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Poscia, Andrea $u Institute of Public Health, Università Cattolica del Sacro Cuore of Rome, Rome, Italy.
245    10
$a Influenza and pneumococcal vaccination in older adults living in nursing home: a survival analysis on the shelter study / $c A. Poscia, A. Collamati, A. Carfì, E. Topinkova, T. Richter, M. Denkinger, R. Pastorino, F. Landi, W. Ricciardi, R. Bernabei, G. Onder,
520    9_
$a Background: Influenza and pneumococcal vaccines have been proved to be effective and safe in preventing and controlling infection among elderly, reducing morbidity and mortality. However, some evidences raised health concerns related to these vaccinations. This study aims to identify prevalence and outcomes related to influenza and pneumococcal vaccinations in a large European population of frail old people living in nursing homes (NHs). Methods: We conducted a survival analysis of NH residents participating to the Services and Health for Elderly in Long-TERm project, a prospective cohort study collecting information on residents admitted to 57 NH in eight countries (Czech Republic, England, Finland, France, Germany, Italy, The Netherlands and Israel). Clinical and demographical data were collected using the international resident assessement instrument for long-term care facilities. Incident mortality was recorded during 1-year follow-up. A shared-frailty Cox regression model was used to assess the impact of vaccination status on mortality. Results: Mean age of 3510 participants was 84.6 years (SD = 7.7). In total, 81.7 and 27.0% received influenza and pneumococcal vaccination, respectively. Overall, 727 (20.7%) residents died during the follow-up period. After adjusting for potential confounders, which included age, sex, number of diseases, depression, cognitive and functional status, influenza (HR = 0.80; 95% CI 0.66-0.97) and the combination of influenza and pneumococcal vaccination (HR = 0.72; 95% CI 0.57-0.91), but not pneumococcal vaccination alone (HR = 0.52; 95% CI 0.25-1.06), were associated with a statistically significant reduction in mortality in respect of no vaccinations. Conclusion: In a population of older adult living in NH influenza and the combination of influenza and pneumococcal vaccination were associated with a reduction in all-cause mortality respect to no vaccination.
650    _2
$a senioři nad 80 let $7 D000369
650    _2
$a Evropa $x epidemiologie $7 D005060
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a křehký senior $x statistika a číselné údaje $7 D016330
650    _2
$a lidé $7 D006801
650    _2
$a vakcíny proti chřipce $x terapeutické užití $7 D007252
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a mortalita $7 D009026
650    _2
$a pečovatelské domovy $x statistika a číselné údaje $7 D009735
650    _2
$a pneumokokové vakcíny $x terapeutické užití $7 D022242
650    _2
$a proporcionální rizikové modely $7 D016016
650    _2
$a analýza přežití $7 D016019
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Collamati, Agnese $u Department of Geriatrics, Neurosciences, and Orthopedics, Università Cattolica del Sacro Cuore of Rome, Rome, Italy.
700    1_
$a Carfì, Angelo $u Department of Geriatrics, Neurosciences, and Orthopedics, Università Cattolica del Sacro Cuore of Rome, Rome, Italy.
700    1_
$a Topinkova, Eva $u Department of Geriatrics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
700    1_
$a Richter, Tomas $u Department of Geriatrics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
700    1_
$a Denkinger, Michael $u GAPLESION Bethesda Clinic, Competence Centre of Geriatrics, University of Ulm, Ulm, Germany.
700    1_
$a Pastorino, Roberta $u Institute of Public Health, Università Cattolica del Sacro Cuore of Rome, Rome, Italy.
700    1_
$a Landi, Francesco $u Department of Geriatrics, Neurosciences, and Orthopedics, Università Cattolica del Sacro Cuore of Rome, Rome, Italy.
700    1_
$a Ricciardi, Walter $u Institute of Public Health, Università Cattolica del Sacro Cuore of Rome, Rome, Italy. National Institute of Health, Rome, Italy.
700    1_
$a Bernabei, Roberto $u Department of Geriatrics, Neurosciences, and Orthopedics, Università Cattolica del Sacro Cuore of Rome, Rome, Italy.
700    1_
$a Onder, Graziano $u Department of Geriatrics, Neurosciences, and Orthopedics, Università Cattolica del Sacro Cuore of Rome, Rome, Italy.
773    0_
$w MED00012099 $t European journal of public health $x 1464-360X $g Roč. 27, č. 6 (2017), s. 1016-1020
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29069321 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20180709 $b ABA008
991    __
$a 20180713114623 $b ABA008
999    __
$a ok $b bmc $g 1316664 $s 1021454
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 27 $c 6 $d 1016-1020 $i 1464-360X $m European journal of public health $n Eur J Public Health $x MED00012099
LZP    __
$a Pubmed-20180709

Find record

Citation metrics

Archiving options