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Nucleoside-O-Methyl-(H)-Phosphinates: Novel Monomers for the Synthesis of Methylphosphonate Oligonucleotides Using H-Phosphonate Chemistry
O. Kostov, O. Páv, I. Rosenberg,
Language English Country United States
Document type Journal Article
PubMed
28921496
DOI
10.1002/cpnc.35
Knihovny.cz E-resources
- MeSH
- Oligonucleotides chemical synthesis MeSH
- Organophosphonates MeSH
- Organophosphorus Compounds chemistry MeSH
- Publication type
- Journal Article MeSH
This unit comprises the straightforward synthesis of protected 2'-deoxyribonucleoside-O-methyl-(H)-phosphinates in both 3'- and 5'-series. These compounds represent a new class of monomers compatible with the solid-phase synthesis of oligonucleotides using H-phosphonate chemistry and are suitable for the preparation of both 3'- and 5'-O-methylphosphonate oligonucleotides. The synthesis of 4-toluenesulfonyloxymethyl-(H)-phosphinic acid as a new reagent for the preparation of O-methyl-(H)-phosphinic acid derivatives is described. © 2017 by John Wiley & Sons, Inc.
References provided by Crossref.org
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