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Relative amount of telomeric sequences in terminal villi does not differ between normal term placentas and placentas from patients with well-controlled type 1 diabetes mellitus
A. Zinková, D. Marová, J. Koperdáková, TP. Mirchi, M. Korabečná, M. Jirkovská,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
Perzistentní odkaz
https://www.medvik.cz/link/bmc18024927
- MeSH
- diabetes mellitus 1. typu patofyziologie MeSH
- dospělí MeSH
- homeostáza telomer * MeSH
- laserová záchytná mikrodisekce MeSH
- lidé MeSH
- mladý dospělý MeSH
- placenta fyziologie MeSH
- studie případů a kontrol MeSH
- těhotenství MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
We applied qPCR to compare relative telomere length in terminal villi microdissected from term control placentas and placentas of patients suffering from type 1 diabetes. Significant differences were not found in the relative T/S ratios between placental groups or between the diabetic placentas affected and those not affected with chorangiosis. We hypothesize that there is no relationship between decreased placental proliferative ability in maternal diabetes type 1 and telomere shortening.
Citace poskytuje Crossref.org
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- $a 10.1016/j.placenta.2017.04.016 $2 doi
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- $a Zinková, Alžběta $u Department of Biology and Medical Genetics, First Faculty of Medicine and General University Hospital, Charles University, Albertov 4, 128 00 Prague, Czech Republic. Electronic address: alzbeta.zinkova@lf1.cuni.cz.
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- $a Relative amount of telomeric sequences in terminal villi does not differ between normal term placentas and placentas from patients with well-controlled type 1 diabetes mellitus / $c A. Zinková, D. Marová, J. Koperdáková, TP. Mirchi, M. Korabečná, M. Jirkovská,
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- $a We applied qPCR to compare relative telomere length in terminal villi microdissected from term control placentas and placentas of patients suffering from type 1 diabetes. Significant differences were not found in the relative T/S ratios between placental groups or between the diabetic placentas affected and those not affected with chorangiosis. We hypothesize that there is no relationship between decreased placental proliferative ability in maternal diabetes type 1 and telomere shortening.
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- $a Marová, Dominika $u Department of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, 128 00 Prague, Czech Republic. Electronic address: marova.dominika@centrum.sk.
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- $a Koperdáková, Júlia $u Department of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, 128 00 Prague, Czech Republic. Electronic address: julia.koperdakova@gmail.com.
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- $a Mirchi, Tomáš P $u Department of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, 128 00 Prague, Czech Republic. Electronic address: tpmirchi@gmail.com.
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- $a Korabečná, Marie $u Department of Biology and Medical Genetics, First Faculty of Medicine and General University Hospital, Charles University, Albertov 4, 128 00 Prague, Czech Republic. Electronic address: marie.korabecna@lf1.cuni.cz.
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- $a Jirkovská, Marie $u Department of Histology and Embryology, First Faculty of Medicine, Charles University, Albertov 4, 128 00 Prague, Czech Republic. Electronic address: mjirk@lf1.cuni.cz.
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- $w MED00003835 $t Placenta $x 1532-3102 $g Roč. 55, č. - (2017), s. 1-4
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- $u https://pubmed.ncbi.nlm.nih.gov/28623966 $y Pubmed
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- $a 2017 $b 55 $c - $d 1-4 $e 20170421 $i 1532-3102 $m Placenta $n Placenta $x MED00003835
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- $a Pubmed-20180709
