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MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design
G. Landoni, V. Lomivorotov, A. Pisano, C. Nigro Neto, U. Benedetto, G. Biondi Zoccai, M. Gemma, S. Frassoni, FE. Agrò, M. Baiocchi, FR. Barbosa Gomes Galas, A. Bautin, N. Bradic, C. Carollo, G. Crescenzi, AM. Elnakera, MR. El-Tahan, E. Fominskiy,...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, randomizované kontrolované studie
- MeSH
- analýza přežití MeSH
- anestetika inhalační * aplikace a dávkování chemie MeSH
- anestezie v kardiochirurgii * škodlivé účinky metody MeSH
- dospělí MeSH
- koronární bypass * škodlivé účinky metody mortalita MeSH
- lidé MeSH
- nemoci koronárních tepen mortalita chirurgie MeSH
- pooperační komplikace * etiologie prevence a kontrola MeSH
- volatilizace MeSH
- výsledky a postupy - zhodnocení (zdravotní péče) MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- randomizované kontrolované studie MeSH
OBJECTIVE: There is initial evidence that the use of volatile anesthetics can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalization following coronary artery bypass graft (CABG) surgery. Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage. Thus, whether volatile anesthetics improve the postoperative outcome of cardiac surgical patients remains uncertain. An adequately powered randomized controlled trial appears desirable. DESIGN: Single blinded, international, multicenter randomized controlled trial with 1:1 allocation ratio. SETTING: Tertiary and University hospitals. INTERVENTIONS: Patients (n=10,600) undergoing coronary artery bypass graft will be randomized to receive either volatile anesthetic as part of the anesthetic plan, or total intravenous anesthesia. MEASUREMENTS AND MAIN RESULTS: The primary end point of the study will be one-year mortality (any cause). Secondary endpoints will be 30-day mortality; 30-day death or non-fatal myocardial infarction (composite endpoint); cardiac mortality at 30day and at one year; incidence of hospital re-admission during the one year follow-up period and duration of intensive care unit, and hospital stay. The sample size is based on the hypothesis that volatile anesthetics will reduce 1-year unadjusted mortality from 3% to 2%, using a two-sided alpha error of 0.05, and a power of 0.9. CONCLUSIONS: The trial will determine whether the simple intervention of adding a volatile anesthetic, an intervention that can be implemented by all anesthesiologists, can improve one-year survival in patients undergoing coronary artery bypass graft surgery.
Anaesthesia and Intensive Care Hospital Pulau Pinang Georgetown Malaysia
Anaesthesia and Intensive Care University of Malaya Kuala Lumpur Malaysia
Anestesia e Terapia Intensiva Cardiochirurgica Humanitas Research Hospital Rozzano Italy
Anesthesia and Intensive Care Azienda Ospedaliera San Camillo Forlanini Roma Italy
Anesthesia and Intensive Care Faculty of Medicine Zagazig University Zagazig Egypt
Anesthesia and Intensive care Heart Institute University of Sao Paulo Sao Paulo Brazil
Anesthesia and Intensive Care S Orsola Malpighi University Hospital Bologna Italy
Anesthetic Department Hospital de Santa Maria Lisboa Portugal
Cardiothoracic ICU and Anaesthesia MKCC West Riffa Bahrain
Center for Anesthesiology Beijing Anzhen Hospital Capital Medical University Beijing China
Department Anesthesia and Intensive Care ACIBADEM City Clinic Burgas Burgas Bulgaria
Department of Anaesthesiology and Intensive Care Sarawak General Hospital Kuching Sarawak Malaysia
Department of Anaesthetics King's College Hospital NHS Foundation Trust London United Kingdom
Department of Anesthesiology and Intensive Care Cardiovascular Institute `Dedinje` Belgrade Serbia
Department of Anesthesiology and Intensive Care Ural Institute of Cardiology Ekaterinburg Russia
Department of Anesthesiology Qilu Hospital of Shandong University Shandong China
Department of Anesthesiology The 2nd Xiangya Hospital of Central South University Changsha China
Department of Anesthesiology Wuhan Asia Heart Hospital Wuhan China
Department of AngioCardioNeurology IRCCS Neuromed Pozzilli Italy
Department of Medico Surgical Sciences and Biotechnologies Sapienza University of Rome Latina Italy
Dipartimento Cardiotoracico Azienda Ospedaliera Spedali Civili Brescia Italy
The University of Melbourne Melbourne Victoria Australia
University of Bristol School of Clinical Sciences Bristol Heart Institute Bristol United Kingdom
Citace poskytuje Crossref.org
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- $a Landoni, Giovanni $u Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy. Electronic address: landoni.giovanni@hsr.it.
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- $a MortalitY in caRdIAc surgery (MYRIAD): A randomizeD controlled trial of volatile anesthetics. Rationale and design / $c G. Landoni, V. Lomivorotov, A. Pisano, C. Nigro Neto, U. Benedetto, G. Biondi Zoccai, M. Gemma, S. Frassoni, FE. Agrò, M. Baiocchi, FR. Barbosa Gomes Galas, A. Bautin, N. Bradic, C. Carollo, G. Crescenzi, AM. Elnakera, MR. El-Tahan, E. Fominskiy, AG. Farag, G. Gazivoda, S. Gianni, E. Grigoryev, F. Guarracino, S. Hanafi, W. Huang, G. Kunst, J. Kunstyr, C. Lei, R. Lembo, ZJ. Li, V. Likhvantsev, A. Lozovskiy, J. Ma, F. Monaco, P. Navalesi, B. Nazar, V. Pasyuga, E. Porteri, C. Royse, L. Ruggeri, H. Riha, F. Santos Silva, L. Severi, V. Shmyrev, N. Uvaliev, CB. Wang, CY. Wang, D. Winterton, CY. Yong, J. Yu, R. Bellomo, A. Zangrillo,
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- $a OBJECTIVE: There is initial evidence that the use of volatile anesthetics can reduce the postoperative release of cardiac troponin I, the need for inotropic support, and the number of patients requiring prolonged hospitalization following coronary artery bypass graft (CABG) surgery. Nevertheless, small randomized controlled trials have failed to demonstrate a survival advantage. Thus, whether volatile anesthetics improve the postoperative outcome of cardiac surgical patients remains uncertain. An adequately powered randomized controlled trial appears desirable. DESIGN: Single blinded, international, multicenter randomized controlled trial with 1:1 allocation ratio. SETTING: Tertiary and University hospitals. INTERVENTIONS: Patients (n=10,600) undergoing coronary artery bypass graft will be randomized to receive either volatile anesthetic as part of the anesthetic plan, or total intravenous anesthesia. MEASUREMENTS AND MAIN RESULTS: The primary end point of the study will be one-year mortality (any cause). Secondary endpoints will be 30-day mortality; 30-day death or non-fatal myocardial infarction (composite endpoint); cardiac mortality at 30day and at one year; incidence of hospital re-admission during the one year follow-up period and duration of intensive care unit, and hospital stay. The sample size is based on the hypothesis that volatile anesthetics will reduce 1-year unadjusted mortality from 3% to 2%, using a two-sided alpha error of 0.05, and a power of 0.9. CONCLUSIONS: The trial will determine whether the simple intervention of adding a volatile anesthetic, an intervention that can be implemented by all anesthesiologists, can improve one-year survival in patients undergoing coronary artery bypass graft surgery.
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- $a Nigro Neto, Caetano $u Anesthesia Section of Cardiothoracic Surgery, Dante Pazzanese Institute of Cardiology, Sao Paulo, Brazil.
- 700 1_
- $a Benedetto, Umberto $u University of Bristol, School of Clinical Sciences, Bristol Heart Institute, Bristol, United Kingdom.
- 700 1_
- $a Biondi Zoccai, Giuseppe $u Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy; Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli, Italy.
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- 700 1_
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- 700 1_
- $a Agrò, Felice Eugenio $u Anaesthesia, Intensive Care and Pain Management Department, University School of Medicine Campus Bio-Medico, Rome, Italy.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a El-Tahan, Mohamed R $u Cardiothoracic Anaesthesia & Surgical Intensive Care, King Fahd Hospital, University of Dammam, Al Khobar, Saudi Arabia.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Grigoryev, Evgeny $u Deputy Director for Clinical and Scientific Affairs, Scientific Research Institute of Complex Issues of Cardiovascular Disease, Kemerovo, Russia.
- 700 1_
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- 700 1_
- $a Hanafi, Sidik $u Department of Anaesthesiology and Intensive Care, Sarawak General Hospital, Kuching, Sarawak, Malaysia.
- 700 1_
- $a Huang, Weiqing $u Department of Anesthesiology, Wuhan Asia Heart Hospital, Wuhan, China.
- 700 1_
- $a Kunst, Gudrun $u Department of Anaesthetics, King's College Hospital NHS Foundation Trust, London, United Kingdom.
- 700 1_
- $a Kunstyr, Jan $u Department of Anesthesiology and Intensive Care, First Faculty of Medicine, General University Hospital in Prague, Prague, Czech Republic.
- 700 1_
- $a Lei, Chong $u Department of Anesthesiology and Perioperative Medicine, 1st Affiliative Hospital (Xijing Hospital), Fourth Military Medical University, Xi'an, China.
- 700 1_
- $a Lembo, Rosalba $u Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan 20132, Italy.
- 700 1_
- $a Li, Zhi-Jian $u Department of Anesthesiology, The Second Xiangya Hospital of Central South University, Changsha, China.
- 700 1_
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