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Dysfunctions in striatal microstructure can enhance perceptual decision making through deficits in predictive coding
C. Beste, M. Mückschel, R. Rosales, A. Domingo, L. Lee, A. Ng, C. Klein, A. Münchau,
Language English Country Germany
Document type Journal Article
NLK
ProQuest Central
from 2007-07-01 to 1 year ago
Medline Complete (EBSCOhost)
from 2007-07-01 to 1 year ago
Nursing & Allied Health Database (ProQuest)
from 2007-07-01 to 1 year ago
Health & Medicine (ProQuest)
from 2007-07-01 to 1 year ago
Psychology Database (ProQuest)
from 1997-01-01 to 1 year ago
- MeSH
- Corpus Striatum physiopathology MeSH
- Adult MeSH
- Dystonic Disorders physiopathology psychology MeSH
- Electroencephalography MeSH
- Evoked Potentials MeSH
- Genetic Diseases, X-Linked physiopathology psychology MeSH
- Middle Aged MeSH
- Humans MeSH
- Brain physiopathology MeSH
- Reaction Time MeSH
- Decision Making physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Publication type
- Journal Article MeSH
An important brain function is to predict upcoming events on the basis of extracted regularities of previous inputs. These predictive coding processes can disturb performance in concurrent perceptual decision-making and are known to depend on fronto-striatal circuits. However, it is unknown whether, and if so, to what extent striatal microstructural properties modulate these processes. We addressed this question in a human disease model of striosomal dysfunction, i.e. X-linked dystonia-parkinsonism (XDP), using high-density EEG recordings and source localization. The results show faster and more accurate perceptual decision-making performance during distraction in XDP patients compared to healthy controls. The electrophysiological data show that sensory memory and predictive coding processes reflected by the mismatch negativity related to lateral prefrontal brain regions were weakened in XDP patients and thus induced less cognitive conflict than in controls as reflected by the N2 event-related potential (ERP). Consequently, attentional shifting (P3a ERP) and reorientation processes (RON ERP) were less pronounced in the XDP group. Taken together, these results suggests that striosomal dysfunction is related to predictive coding deficits leading to a better performance in concomitant perceptual decision-making, probably because predictive coding does not interfere with perceptual decision-making processes. These effects may reflect striatal imbalances between the striosomes and the matrix compartment.
Faculty of Neurology and Psychiatry University of Santo Tomas Manila Philippines
Institute of Neurogenetics University of Lübeck Lübeck Germany
XDP Study Group Philippine Children's Medical Center Quezon City Philippines
References provided by Crossref.org
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