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Multiple sclerosis patients have a distinct gut microbiota compared to healthy controls
J. Chen, N. Chia, KR. Kalari, JZ. Yao, M. Novotna, MM. Paz Soldan, DH. Luckey, EV. Marietta, PR. Jeraldo, X. Chen, BG. Weinshenker, M. Rodriguez, OH. Kantarci, H. Nelson, JA. Murray, AK. Mangalam,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
PubMed Central
od 2011
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od 2011
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od 2011-01-01 do 2019-12-31
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od 2011-01-01
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od 2011-01-01
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od 2011-01-01 do 2019-12-31
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od 2011
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od 2011-12-01
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od 2011-12-01
PubMed
27346372
DOI
10.1038/srep28484
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- dysbióza mikrobiologie MeSH
- gastrointestinální trakt mikrobiologie MeSH
- lidé MeSH
- mikrobiota genetika MeSH
- RNA ribozomální 16S genetika MeSH
- roztroušená skleróza mikrobiologie MeSH
- střevní mikroflóra genetika MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Multiple sclerosis (MS) is an immune-mediated disease, the etiology of which involves both genetic and environmental factors. The exact nature of the environmental factors responsible for predisposition to MS remains elusive; however, it's hypothesized that gastrointestinal microbiota might play an important role in pathogenesis of MS. Therefore, this study was designed to investigate whether gut microbiota are altered in MS by comparing the fecal microbiota in relapsing remitting MS (RRMS) (n = 31) patients to that of age- and gender-matched healthy controls (n = 36). Phylotype profiles of the gut microbial populations were generated using hypervariable tag sequencing of the V3-V5 region of the 16S ribosomal RNA gene. Detailed fecal microbiome analyses revealed that MS patients had distinct microbial community profile compared to healthy controls. We observed an increased abundance of Psuedomonas, Mycoplana, Haemophilus, Blautia, and Dorea genera in MS patients, whereas control group showed increased abundance of Parabacteroides, Adlercreutzia and Prevotella genera. Thus our study is consistent with the hypothesis that MS patients have gut microbial dysbiosis and further study is needed to better understand their role in the etiopathogenesis of MS.
Department of Gastroenterology Mayo Clinic Rochester MN 55905 USA
Department of Immunology Mayo Clinic 200 1st ST SW Rochester MN 55905 USA
Department of Surgical Research Mayo Clinic 200 1st ST SW Rochester MN 55905 USA
Citace poskytuje Crossref.org
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