Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Left hippocampus sparing whole brain radiotherapy (WBRT): A planning study

T. Kazda, M. Vrzal, T. Prochazka, P. Dvoracek, P. Burkon, P. Pospisil, A. Dziacky, T. Nikl, R. Jancalek, P. Slampa, R. Lakomy

. 2017 ; 161 (4) : 397-402. [pub] 20170720

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18028563

AIMS: Unilateral sparing of the dominant (left) hippocampus during whole brain radiotherapy (WBRT) could mitigate cognitive decline, especially verbal memory, similar to the widely investigated bilateral hippocampus avoidance (HA-WBRT). The aim of this planning study is dosimetrical comparison of HA-WBRT with only left hippocampus sparing (LHA-WBRT) plans. METHODS: HA-WBRT plans for 10 patients were prepared in accordance with RTOG 0933 trial and served as baseline for comparisons with several LHA-WBRT plans prepared with an effort: 1) to maintain the same left hippocampus dosimetry ("BEST PTV") and 2) to maintain same dosimetry in planning target volume as in HA-WBRT ("BEST LH"). RESULTS: All HA-WBRT plans met RTOG 0933 protocol criteria with a mean Conformity index 1.09 and mean Homogeneity index (HI) 0.21. Mean right and left hippocampal D100% was 7.8 Gy and 8.5 Gy and mean Dmax 14.0 Gy and 13.8 Gy, respectively. "BEST PTV" plans reduced HI by 31.2% (P=0.005) which is mirrored by lower PTV_D2% (-0.8 Gy, P=0.005) and higher PTV_D98% (+1.3 Gy, P=0.005) as well as decreased optic pathway's Dmax by 1 Gy. In "BEST LH", mean D100% and Dmax for the left hippocampus were significantly reduced by 11.2% (P=0.005) and 10.9% (P=0.005) respectively. CONCLUSIONS: LHA-WBRT could improve target coverage and/or further decrease in dose to spared hippocampus. Future clinical trials must confirm whether statistically significant reduction in left hippocampal dose is also clinically significant.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18028563
003      
CZ-PrNML
005      
20180824131403.0
007      
ta
008      
180816s2017 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.5507/bp.2017.031 $2 doi
035    __
$a (PubMed)28731074
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Kazda, Tomáš $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University,Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic $7 xx0213412
245    10
$a Left hippocampus sparing whole brain radiotherapy (WBRT): A planning study / $c T. Kazda, M. Vrzal, T. Prochazka, P. Dvoracek, P. Burkon, P. Pospisil, A. Dziacky, T. Nikl, R. Jancalek, P. Slampa, R. Lakomy
520    9_
$a AIMS: Unilateral sparing of the dominant (left) hippocampus during whole brain radiotherapy (WBRT) could mitigate cognitive decline, especially verbal memory, similar to the widely investigated bilateral hippocampus avoidance (HA-WBRT). The aim of this planning study is dosimetrical comparison of HA-WBRT with only left hippocampus sparing (LHA-WBRT) plans. METHODS: HA-WBRT plans for 10 patients were prepared in accordance with RTOG 0933 trial and served as baseline for comparisons with several LHA-WBRT plans prepared with an effort: 1) to maintain the same left hippocampus dosimetry ("BEST PTV") and 2) to maintain same dosimetry in planning target volume as in HA-WBRT ("BEST LH"). RESULTS: All HA-WBRT plans met RTOG 0933 protocol criteria with a mean Conformity index 1.09 and mean Homogeneity index (HI) 0.21. Mean right and left hippocampal D100% was 7.8 Gy and 8.5 Gy and mean Dmax 14.0 Gy and 13.8 Gy, respectively. "BEST PTV" plans reduced HI by 31.2% (P=0.005) which is mirrored by lower PTV_D2% (-0.8 Gy, P=0.005) and higher PTV_D98% (+1.3 Gy, P=0.005) as well as decreased optic pathway's Dmax by 1 Gy. In "BEST LH", mean D100% and Dmax for the left hippocampus were significantly reduced by 11.2% (P=0.005) and 10.9% (P=0.005) respectively. CONCLUSIONS: LHA-WBRT could improve target coverage and/or further decrease in dose to spared hippocampus. Future clinical trials must confirm whether statistically significant reduction in left hippocampal dose is also clinically significant.
650    _2
$a nádory mozku $x radioterapie $x sekundární $7 D001932
650    _2
$a ženské pohlaví $7 D005260
650    12
$a hipokampus $7 D006624
650    _2
$a lidé $7 D006801
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a lidé středního věku $7 D008875
650    _2
$a léčba šetřící orgány $7 D059351
650    _2
$a kritické orgány $7 D058958
650    _2
$a dávka záření $7 D011829
650    _2
$a celková dávka radioterapie $7 D011879
650    12
$a plánování radioterapie pomocí počítače $7 D011880
650    _2
$a retrospektivní studie $7 D012189
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vrzal, Miroslav. $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic $7 xx0233526
700    1_
$a Procházka, Tomáš $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic $7 xx0135122
700    1_
$a Dvoracek, Petr $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
700    1_
$a Burkoň, Petr $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic $7 xx0233520
700    1_
$a Pospíšil, Petr $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic $7 xx0173603
700    1_
$a Dziacky, Adam $u Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Nikl, Tomas $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic
700    1_
$a Jančálek, Radim, $u Department of Neurosurgery, St. Anne's University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Neurosurgery, St. Anne's University Hospital Brno, Brno, Czech Republic $d 1975- $7 xx0037113
700    1_
$a Šlampa, Pavel, $u Department of Radiation Oncology, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Radiation Oncology, Masaryk Memorial Cancer Institute, Brno, Czech Republic; Regional Center for Applied Molecular Oncology (RECAMO), Masaryk Memorial Cancer Institute, Brno, Czech Republic $d 1960- $7 mzk2004257405
700    1_
$a Lakomý, Radek $u Department of Comprehensive Cancer Care, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute, Brno, Czech Republic $7 xx0164218
773    0_
$w MED00012606 $t Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czech Republic $x 1213-8118 $g Roč. 161, č. 4 (2017), s. 397-402
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28731074 $y Pubmed
910    __
$a ABA008 $b A 1502 $c 958 $y 4 $z 0
990    __
$a 20180816 $b ABA008
991    __
$a 20180823144953 $b ABA008
999    __
$a ok $b bmc $g 1328642 $s 1025518
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2017 $b 161 $c 4 $d 397-402 $e 20170720 $i 1213-8118 $m Biomedical papers of the Medical Faculty of the University Palacký, Olomouc Czech Republic $n Biomed. Pap. Fac. Med. Palacký Univ. Olomouc Czech Repub. (Print) $x MED00012606
LZP    __
$b NLK118 $a Pubmed-20180816
Zpět

Najít záznam

Citační ukazatele

Možnosti archivace