Detail
Článek
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Effects of increased myocardial tissue concentration of myristic, palmitic and palmitoleic acids on the course of cardiac atrophy of the failing heart unloaded by heterotopic transplantation

M. Pokorný, I. Mrázová, J. Malý, J. Pirk, I. Netuka, Z. Vaňourková, Š. Doleželová, L. Červenková, H. Maxová, V. Melenovský, J. Šochman, J. Sadowski, L. Červenka

. 2018 ; 67 (1) : 13-30. [pub] 20171110

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18031094

Grantová podpora
NV16-27420A MZ0 CEP - Centrální evidence projektů

The present experiments were performed to evaluate if increased heart tissue concentration of fatty acids, specifically myristic, palmitic and palmitoleic acids that are believed to promote physiological heart growth, can attenuate the progression of unloading-induced cardiac atrophy in rats with healthy and failing hearts. Heterotopic abdominal heart transplantation (HT(x)) was used as a model for heart unloading. Cardiac atrophy was assessed from the ratio of the native- to-transplanted heart weight (HW). The degree of cardiac atrophy after HT(x) was determined on days 7, 14, 21 and 28 after HT(x) in recipients of either healthy or failing hearts. HT(x) of healthy hearts resulted in 23+/-3, 46+/-3, 48+/-4 and 46+/-4 % HW loss at the four time-points. HT(x) of the failing heart resulted in even greater HW losses, of 46+/-4, 58+/-3, 66+/-2 and 68+/-4 %, respectively (P<0.05). Activation of "fetal gene cardiac program" (e.g. beta myosin heavy chain gene expression) and "genes reflecting cardiac remodeling" (e.g. atrial natriuretic peptide gene expression) after HT(x) was greater in failing than in healthy hearts (P<0.05 each time). Exposure to isocaloric high sugar diet caused significant increases in fatty acid concentrations in healthy and in failing hearts. However, these increases were not associated with any change in the course of cardiac atrophy, similarly in healthy and post-HT(x) failing hearts. We conclude that increasing heart tissue concentrations of the fatty acids allegedly involved in heart growth does not attenuate the unloading-induced cardiac atrophy.

000      
00000naa a2200000 a 4500
001      
bmc18031094
003      
CZ-PrNML
005      
20181001143915.0
007      
ta
008      
180914s2018 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.933637 $2 doi
035    __
$a (PubMed)29137478
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Pokorný, Martin $7 xx0227636 $u Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
245    10
$a Effects of increased myocardial tissue concentration of myristic, palmitic and palmitoleic acids on the course of cardiac atrophy of the failing heart unloaded by heterotopic transplantation / $c M. Pokorný, I. Mrázová, J. Malý, J. Pirk, I. Netuka, Z. Vaňourková, Š. Doleželová, L. Červenková, H. Maxová, V. Melenovský, J. Šochman, J. Sadowski, L. Červenka
520    9_
$a The present experiments were performed to evaluate if increased heart tissue concentration of fatty acids, specifically myristic, palmitic and palmitoleic acids that are believed to promote physiological heart growth, can attenuate the progression of unloading-induced cardiac atrophy in rats with healthy and failing hearts. Heterotopic abdominal heart transplantation (HT(x)) was used as a model for heart unloading. Cardiac atrophy was assessed from the ratio of the native- to-transplanted heart weight (HW). The degree of cardiac atrophy after HT(x) was determined on days 7, 14, 21 and 28 after HT(x) in recipients of either healthy or failing hearts. HT(x) of healthy hearts resulted in 23+/-3, 46+/-3, 48+/-4 and 46+/-4 % HW loss at the four time-points. HT(x) of the failing heart resulted in even greater HW losses, of 46+/-4, 58+/-3, 66+/-2 and 68+/-4 %, respectively (P<0.05). Activation of "fetal gene cardiac program" (e.g. beta myosin heavy chain gene expression) and "genes reflecting cardiac remodeling" (e.g. atrial natriuretic peptide gene expression) after HT(x) was greater in failing than in healthy hearts (P<0.05 each time). Exposure to isocaloric high sugar diet caused significant increases in fatty acid concentrations in healthy and in failing hearts. However, these increases were not associated with any change in the course of cardiac atrophy, similarly in healthy and post-HT(x) failing hearts. We conclude that increasing heart tissue concentrations of the fatty acids allegedly involved in heart growth does not attenuate the unloading-induced cardiac atrophy.
650    _2
$a zvířata $7 D000818
650    _2
$a kyseliny mastné mononenasycené $x metabolismus $7 D005229
650    _2
$a srdeční selhání $x metabolismus $x chirurgie $7 D006333
650    _2
$a transplantace srdce $x metody $7 D016027
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a myokard $x metabolismus $x patologie $7 D009206
650    _2
$a kardiomyocyty $x metabolismus $7 D032383
650    _2
$a kyselina myristová $x metabolismus $7 D019814
650    _2
$a kyselina palmitová $x metabolismus $7 D019308
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani inbrední LEW $7 D011917
650    _2
$a heterotopická transplantace $x metody $7 D016042
655    _2
$a časopisecké články $7 D016428
700    1_
$a Mrázová, Iveta $7 xx0227642 $u Department of Pathophysiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Malý, Jiří $7 xx0090515 $u Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Pirk, Jan, $d 1948- $7 nlk19990073700 $u Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Netuka, Ivan, $d 1973- $7 xx0074183 $u Department of Cardiovascular Surgery, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Vaňourková, Zdeňka, $d 1973- $7 xx0074217 $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Doleželová, Šárka $7 xx0227631 $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Červenková, Lenka $7 xx0227643 $u Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Maxová, Hana, $d 1968- $7 xx0037102 $u Department of Pathophysiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic
700    1_
$a Melenovský, Vojtěch $7 xx0160847 $u Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Šochman, Jan, $d 1956- $7 xx0088500 $u Department of Cardiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Sadowski, Janusz, $d 1937- $7 xx0227641 $u Department of Renal and Body Fluid Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
700    1_
$a Červenka, Luděk, $d 1967- $7 xx0037105 $u Department of Pathophysiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic; Center for Experimental Medicine, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 67, č. 1 (2018), s. 13-30
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29137478 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y 4 $z 0
990    __
$a 20180914 $b ABA008
991    __
$a 20181001144352 $b ABA008
999    __
$a ok $b bmc $g 1335337 $s 1028067
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 67 $c 1 $d 13-30 $e 20171110 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
GRA    __
$a NV16-27420A $p MZ0
LZP    __
$b NLK118 $a Pubmed-20180914

Najít záznam

Citační ukazatele

Možnosti archivace