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Ontogenetic development of sensitivity of the cerebral cortex to an antagonist of GABA(A) receptor bicuculline
P. Mareš, K. Bernášková, H. Kubová
Language English Country Czech Republic
Document type Journal Article
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- MeSH
- GABA-A Receptor Antagonists pharmacology MeSH
- Bicuculline pharmacology therapeutic use MeSH
- Electroencephalography drug effects MeSH
- Rats MeSH
- Rats, Wistar MeSH
- Receptors, GABA-A physiology MeSH
- Somatosensory Cortex drug effects growth & development MeSH
- Age Factors MeSH
- Seizures drug therapy physiopathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Local application of four concentrations of bicuculline methiodide (a specific antagonist of GABA(A) receptors) was used to study a sensitivity of somatosensory cortex in four age groups of immature rats with implanted electrodes. Presence and latencies of two epileptic phenomena (focal discharges and seizures) were evaluated. Focal discharges exhibited moderate tendency to a decrease of sensitivity to bicuculline methiodide with maturation. Concentration-effect relation of incidence of focal discharges was observed only in 7- and 12-day-old but not in older animals. Results with incidence and latencies of seizures did not show relations to age or concentration of bicuculline. Neither of the epileptic phenomena can be used as a reliable index of cortical maturation.
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