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Ontogenetic development of sensitivity of the cerebral cortex to an antagonist of GABA(A) receptor bicuculline
P. Mareš, K. Bernášková, H. Kubová
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 1991
Free Medical Journals
od 1998
ProQuest Central
od 2005-01-01
Medline Complete (EBSCOhost)
od 2006-01-01
Nursing & Allied Health Database (ProQuest)
od 2005-01-01
Health & Medicine (ProQuest)
od 2005-01-01
ROAD: Directory of Open Access Scholarly Resources
od 1998
- MeSH
- antagonisté receptorů GABA-A farmakologie MeSH
- bikukulin farmakologie terapeutické užití MeSH
- elektroencefalografie účinky léků MeSH
- krysa rodu rattus MeSH
- potkani Wistar MeSH
- receptory GABA-A fyziologie MeSH
- somatosenzorické korové centrum účinky léků růst a vývoj MeSH
- věkové faktory MeSH
- záchvaty farmakoterapie patofyziologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Local application of four concentrations of bicuculline methiodide (a specific antagonist of GABA(A) receptors) was used to study a sensitivity of somatosensory cortex in four age groups of immature rats with implanted electrodes. Presence and latencies of two epileptic phenomena (focal discharges and seizures) were evaluated. Focal discharges exhibited moderate tendency to a decrease of sensitivity to bicuculline methiodide with maturation. Concentration-effect relation of incidence of focal discharges was observed only in 7- and 12-day-old but not in older animals. Results with incidence and latencies of seizures did not show relations to age or concentration of bicuculline. Neither of the epileptic phenomena can be used as a reliable index of cortical maturation.
Citace poskytuje Crossref.org
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