Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Tissue Rebuilding During Spontaneous Regression of Melanoma in the Melanoma-bearing Libechov Minipig

D. Planska, J. Kovalska, J. Cizkova, V. Horak,

. 2018 ; 38 (8) : 4629-4636.

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18032996

Grantová podpora
NV15-32432A MZ0 CEP - Centrální evidence projektů

BACKGROUND/AIM: Melanoma is a cancer disease with increasing incidence in the Caucasian population. It is often accompanied by spontaneous regression (SR), probably due to high immunogenicity. Understanding of this phenomenon could allow its induction in clinical practice, but detailed study in humans is impossible for ethical reasons. The aim of this study was to determine the role of fibronectin, tenascin C, and MMP-2 in the process of SR. MATERIALS AND METHODS: Time-lapse study of SR was performed in the MeLiM (Melanoma-bearing Libechov Minipig) model. Skin melanomas were taken from 3 weeks to 8 months of age and immunohistochemically processed for fibronectin, tenascin C and matrix metalloproteinase-2 (MMP-2). RESULTS: Expression of all studied proteins increased up to the 10th week of age. Two structurally different areas were distinguishable from the 3rd month of age. MPP-2 expression predominated in areas with melanoma cells, whereas fibronectin and tenascin-C prevailed in the forming fibrous tissue. CONCLUSION: Rebuilding of melanoma into the fibrous tissue during SR was connected with a general rise in fibronectin and tenascin C expression.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc18032996
003      
CZ-PrNML
005      
20181009105641.0
007      
ta
008      
181008s2018 gr f 000 0|eng||
009      
AR
024    7_
$a 10.21873/anticanres.12767 $2 doi
035    __
$a (PubMed)30061229
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gr
100    1_
$a Planska, Daniela $u Department of Immunology, Third Faculty of Medicine, Charles University, Prague, Czech Republic PlanskaD@seznam.cz. Faculty of Science, Charles University, Prague, Czech Republic. Laboratory of Tumour Biology, Institute of Animal Physiology and Genetics AS CR, v.v.i, Libechov, Czech Republic.
245    10
$a Tissue Rebuilding During Spontaneous Regression of Melanoma in the Melanoma-bearing Libechov Minipig / $c D. Planska, J. Kovalska, J. Cizkova, V. Horak,
520    9_
$a BACKGROUND/AIM: Melanoma is a cancer disease with increasing incidence in the Caucasian population. It is often accompanied by spontaneous regression (SR), probably due to high immunogenicity. Understanding of this phenomenon could allow its induction in clinical practice, but detailed study in humans is impossible for ethical reasons. The aim of this study was to determine the role of fibronectin, tenascin C, and MMP-2 in the process of SR. MATERIALS AND METHODS: Time-lapse study of SR was performed in the MeLiM (Melanoma-bearing Libechov Minipig) model. Skin melanomas were taken from 3 weeks to 8 months of age and immunohistochemically processed for fibronectin, tenascin C and matrix metalloproteinase-2 (MMP-2). RESULTS: Expression of all studied proteins increased up to the 10th week of age. Two structurally different areas were distinguishable from the 3rd month of age. MPP-2 expression predominated in areas with melanoma cells, whereas fibronectin and tenascin-C prevailed in the forming fibrous tissue. CONCLUSION: Rebuilding of melanoma into the fibrous tissue during SR was connected with a general rise in fibronectin and tenascin C expression.
650    _2
$a zvířata $7 D000818
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a fibronektiny $x metabolismus $7 D005353
650    _2
$a matrixová metaloproteinasa 2 $x metabolismus $7 D020778
650    _2
$a melanom $x metabolismus $x patologie $7 D008545
650    _2
$a prasata $7 D013552
650    _2
$a miniaturní prasata $7 D013556
650    _2
$a tenascin $x metabolismus $7 D019063
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kovalska, Jana $u Laboratory of Tumour Biology, Institute of Animal Physiology and Genetics AS CR, v.v.i, Libechov, Czech Republic.
700    1_
$a Cizkova, Jana $u Laboratory of Tumour Biology, Institute of Animal Physiology and Genetics AS CR, v.v.i, Libechov, Czech Republic. Department of Veterinary Sciences, Czech Faculty of Agrobiology, University of Life Sciences, Prague, Czech Republic.
700    1_
$a Horak, Vratislav $u Laboratory of Tumour Biology, Institute of Animal Physiology and Genetics AS CR, v.v.i, Libechov, Czech Republic.
773    0_
$w MED00000478 $t Anticancer research $x 1791-7530 $g Roč. 38, č. 8 (2018), s. 4629-4636
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30061229 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20181008 $b ABA008
991    __
$a 20181009110129 $b ABA008
999    __
$a ok $b bmc $g 1339976 $s 1029990
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 38 $c 8 $d 4629-4636 $i 1791-7530 $m Anticancer research $n Anticancer Res $x MED00000478
GRA    __
$a NV15-32432A $p MZ0
LZP    __
$a Pubmed-20181008

Najít záznam

Citační ukazatele

Možnosti archivace