-
Something wrong with this record ?
The Impact of Immune Interaction on the Metastatic Infiltration of Colorectal Carcinoma to Lymph Nodes
O. Vycital, M. Dubova, R. Palek, P. Hosek, J. Branzovsky, V. Treska, O. Daum, V. Liska,
Language English Country Greece
Document type Journal Article
NLK
Free Medical Journals
from 2004 to 2 years ago
Open Access Digital Library
from 2004-01-01
- MeSH
- Colorectal Neoplasms immunology pathology MeSH
- Humans MeSH
- Lymphatic Metastasis immunology pathology MeSH
- Biomarkers, Tumor immunology MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Lymphocytes, Tumor-Infiltrating immunology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
BACKGROUND/AIM: Tumour-infiltrating lymphocytes (TILs) and Granzyme B play crucial roles in immune reactions against colorectal carcinoma (CRCa). The inhibitor of Granzyme B is Serpin B9. The aim of this study was to evaluate the effect of immunohistological parameters of TILs on the prognosis of CRCa and presence of lymph node metastasis. PATIENTS AND METHODS: A total of 152 patients who underwent surgery for CRCa were analyzed, including 63 patients in cohort stage II, according to the Union for International Cancer Control (UICC), and 89 patients in cohort UICC stage III. The TIL pattern was classified as peritumoural (PTL), intratumoural (ITL), intrastromal (ISL) or Crohn-like, and immunohistological staining of TIL and cancer cells was also performed. RESULTS: A significantly higher density of CD8+ and CD4+ TILs was observed in the UICC II group, and significantly higher densities of CD4+ TILs were observed in the UICC II group in all distinguished patterns. In the same cohort, higher numbers of CD57+ cells and FoxP3+ TILs and Granzyme B levels were observed. In cohort UICC III, there was a higher density of ISL, PTL CD8+, CD25+ TILs and cancer cells showed staining for Serpin B9. CD57, Granzyme B and CD8 were demonstrated as positive prognostic factors of overall survival, and CD57 and CD4+ TILs were demonstrated as positive prognostic factors of recurrence. CONCLUSION: TILs and CD57 are promising prognostic factors of CRCa. The association of Serpin B9 with lymph node metastasis reveals a potential mechanism for tumour resistance to immune reaction.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc18033014
- 003
- CZ-PrNML
- 005
- 20181009105643.0
- 007
- ta
- 008
- 181008s2018 gr f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.21873/anticanres.12709 $2 doi
- 035 __
- $a (PubMed)29970545
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gr
- 100 1_
- $a Vycital, Ondrej $u Department of Surgery, Medical School and Teaching Hospital Pilsen, Charles University, Pilsen, Czech Republic vycitalo@fnplzen.cz. Biomedical Centre, Medical School and Teaching Hospital Pilsen, Charles University, Pilsen, Czech Republic.
- 245 14
- $a The Impact of Immune Interaction on the Metastatic Infiltration of Colorectal Carcinoma to Lymph Nodes / $c O. Vycital, M. Dubova, R. Palek, P. Hosek, J. Branzovsky, V. Treska, O. Daum, V. Liska,
- 520 9_
- $a BACKGROUND/AIM: Tumour-infiltrating lymphocytes (TILs) and Granzyme B play crucial roles in immune reactions against colorectal carcinoma (CRCa). The inhibitor of Granzyme B is Serpin B9. The aim of this study was to evaluate the effect of immunohistological parameters of TILs on the prognosis of CRCa and presence of lymph node metastasis. PATIENTS AND METHODS: A total of 152 patients who underwent surgery for CRCa were analyzed, including 63 patients in cohort stage II, according to the Union for International Cancer Control (UICC), and 89 patients in cohort UICC stage III. The TIL pattern was classified as peritumoural (PTL), intratumoural (ITL), intrastromal (ISL) or Crohn-like, and immunohistological staining of TIL and cancer cells was also performed. RESULTS: A significantly higher density of CD8+ and CD4+ TILs was observed in the UICC II group, and significantly higher densities of CD4+ TILs were observed in the UICC II group in all distinguished patterns. In the same cohort, higher numbers of CD57+ cells and FoxP3+ TILs and Granzyme B levels were observed. In cohort UICC III, there was a higher density of ISL, PTL CD8+, CD25+ TILs and cancer cells showed staining for Serpin B9. CD57, Granzyme B and CD8 were demonstrated as positive prognostic factors of overall survival, and CD57 and CD4+ TILs were demonstrated as positive prognostic factors of recurrence. CONCLUSION: TILs and CD57 are promising prognostic factors of CRCa. The association of Serpin B9 with lymph node metastasis reveals a potential mechanism for tumour resistance to immune reaction.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a nádorové biomarkery $x imunologie $7 D014408
- 650 _2
- $a kolorektální nádory $x imunologie $x patologie $7 D015179
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a lymfatické metastázy $x imunologie $x patologie $7 D008207
- 650 _2
- $a tumor infiltrující lymfocyty $x imunologie $7 D016246
- 650 _2
- $a mužské pohlaví $7 D008297
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Dubova, Magdalena $u Sikl's Institute of Pathology, Faculty of Medicine and Faculty Hospital Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Palek, Richard $u Department of Surgery, Medical School and Teaching Hospital Pilsen, Charles University, Pilsen, Czech Republic. Biomedical Centre, Medical School and Teaching Hospital Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Hosek, Petr $u Biomedical Centre, Medical School and Teaching Hospital Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Branzovsky, Jindrich $u Sikl's Institute of Pathology, Faculty of Medicine and Faculty Hospital Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Treska, Vladislav $u Department of Surgery, Medical School and Teaching Hospital Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Daum, Ondrej $u Sikl's Institute of Pathology, Faculty of Medicine and Faculty Hospital Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Liska, Vaclav $u Department of Surgery, Medical School and Teaching Hospital Pilsen, Charles University, Pilsen, Czech Republic. Biomedical Centre, Medical School and Teaching Hospital Pilsen, Charles University, Pilsen, Czech Republic.
- 773 0_
- $w MED00000478 $t Anticancer research $x 1791-7530 $g Roč. 38, č. 7 (2018), s. 4159-4167
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29970545 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20181008 $b ABA008
- 991 __
- $a 20181009110131 $b ABA008
- 999 __
- $a ok $b bmc $g 1339983 $s 1030008
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 38 $c 7 $d 4159-4167 $i 1791-7530 $m Anticancer research $n Anticancer Res $x MED00000478
- LZP __
- $a Pubmed-20181008
