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Water-Soluble Polysaccharide Extracts from the Oyster Culinary-Medicinal Mushroom Pleurotus ostreatus (Agaricomycetes) with HMGCR Inhibitory Activity
A. Gil-Ramirez, FR. Smiderle, D. Morales, C. Govers, A. Synytsya, HJ. Wichers, M. Iacomini, C. Soler-Rivas,
Language English Country United States
Document type Journal Article
- MeSH
- Cell Membrane drug effects MeSH
- Caco-2 Cells MeSH
- Epithelial Cells drug effects MeSH
- Hydroxymethylglutaryl CoA Reductases metabolism MeSH
- Enzyme Inhibitors chemistry isolation & purification metabolism MeSH
- Humans MeSH
- Molecular Weight MeSH
- Pleurotus chemistry MeSH
- Polysaccharides chemistry isolation & purification metabolism MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Water extracts from Pleurotus ostreatus containing no statins showed 3-hydroxy-3-methyl-glutaryl CoA reductase (HMGCR) inhibitory activity (in vitro) that might be due to specific water-soluble polysaccharides (WSPs); when isolated and deproteinized, increasing concentrations of the WSP extract induced higher inhibition. The WSP extract contained mainly β-glucans, mannogalactans, and glycogen (e.g., α-glucans), although derivatives or fragments with lower molecular weights (between 14 and 3.5 kDa) were present and were able to induce the inhibitory activity. The extract contained more β-(1→3)-glucans than β-(11→3),(11→6)-glucans, and they partially survived digestion and managed to pass through Caco2 cell monolayers to the lower compartment after in vitro digestion and transport experiments. The WSP might also modulate Caco2 membrane integrity.
Department of Biochemistry and Molecular Biology Federal University of Parana Curitiba Parana Brazil
Department of Carbohydrates and Cereals Institute of Chemical Technology Prague Czech Republic
Food and Biobased Research Wageningen University and Research Centre Wageningen The Netherlands
References provided by Crossref.org
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