The neural architecture of the corpus callosum shows pronounced inter-individual differences. These differences are thought to affect timing of interhemispheric interactions and, in turn, functional hemispheric asymmetries. The present study aimed at elucidating the neuronal mechanisms underlying this relationship. To this end, we used a combined DTI and EEG study design. In 103 right-handed and healthy adult participants, we determined the microstructural integrity of the posterior third of the corpus callosum and examined in how far this microstructural integrity was related to between-hemisphere timing differences in neurophysiological correlates of attentional processes in the dichotic listening task. The results show that microstructural integrity of the posterior callosal third correlated with attentional timing differences in a verbal dichotic listening condition but not in a noise control condition. Hence, this association between callosal microstructure and between-hemisphere timing differences is specific for stimuli, which trigger hemispheric bottom-up processing in an asymmetric fashion. Specifically, higher microstructural integrity was associated with decreased left-right differences in the latency of the N1 event-related potential component and hence more symmetric processing of dichotic stimuli between the two hemispheres. Our data suggest that microstructure of the posterior callosal third affects functional hemispheric asymmetries by modulating the timing of interhemispheric interactions.

Cognitive Neurophysiology Department of Child and Adolescent Psychiatry Faculty of Medicine of the TU Dresden Germany

Experimental Neurobiology National Institute of Mental Health Klecany Czech Republic

Institute of Cognitive Neuroscience Biopsychology Department of Psychology Ruhr University of Bochum Germany

References provided by Crossref.org