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Je něco špatně v tomto záznamu ?
Acidic polysaccharide complexes from purslane, silver linden and lavender stimulate Peyer's patch immune cells through innate and adaptive mechanisms
YN. Georgiev, MH. Ognyanov, H. Kiyohara, TG. Batsalova, BM. Dzhambazov, M. Ciz, PN. Denev, H. Yamada, BS. Paulsen, O. Vasicek, A. Lojek, H. Barsett, D. Antonova, MG. Kratchanova,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- adaptivní imunita účinky léků MeSH
- imunomodulace účinky léků MeSH
- koncentrace vodíkových iontů MeSH
- levandule chemie MeSH
- lidé MeSH
- myši MeSH
- nádorové buněčné linie MeSH
- pektiny chemie MeSH
- Peyerovy pláty účinky léků imunologie MeSH
- polysacharidy chemie farmakologie MeSH
- Portulaca chemie MeSH
- přirozená imunita účinky léků MeSH
- protinádorové látky chemie farmakologie MeSH
- Tilia chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Three polysaccharide complexes (PSCs) were isolated from the aerial parts of common purslane (Portulaca oleracea L.), and the flowers of common lavender (Lavandula angustifolia Mill.) and silver linden (Tilia tomentosa Moench) by boiling water extraction and ethanol precipitation. The chemical composition and immunomodulating effects of isolated PSCs were characterized. The chemical characterization revealed that the three samples contain mainly pectic polysaccharides. They exhibited ex vivo intestinal immunomodulating activity through the murine Peyer's patch-mediated bone marrow cell proliferation test at 100μg/ml concentration. At the same time, they stimulated ex vivo human blood T-cell populations (CD4+/CD25+ and CD8+/CD25+), phagocytic leukocytes (CD14+ and CD64+ cells) and induced IL-6 production from human white blood cells and Peyer's patch cells. The herbal PSCs stimulated ex vivo ROS production from whole blood phagocytes and showed unspecific in vitro anti-proliferative activity against normal and A549, HeLa and LS180 tumor cells. This is the first report on immunomodulating studies of linden flower pectins and chemical and biological activity characterization of lavender polysaccharides. Our study demonstrates that similarly to purslane, lavender and silver linden herbal materials contain immunomodulating polysaccharides that could be useful for support of compromised immune system.
Citace poskytuje Crossref.org
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- $a Georgiev, Yordan N $u Laboratory of Biologically Active Substances, Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, 139 Ruski Blvd., 4000 Plovdiv, Bulgaria; Innovative-Technological Center Ltd., 20 Dr. G. M. Dimitrov Str., 4000 Plovdiv, Bulgaria.
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- $a Acidic polysaccharide complexes from purslane, silver linden and lavender stimulate Peyer's patch immune cells through innate and adaptive mechanisms / $c YN. Georgiev, MH. Ognyanov, H. Kiyohara, TG. Batsalova, BM. Dzhambazov, M. Ciz, PN. Denev, H. Yamada, BS. Paulsen, O. Vasicek, A. Lojek, H. Barsett, D. Antonova, MG. Kratchanova,
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- $a Three polysaccharide complexes (PSCs) were isolated from the aerial parts of common purslane (Portulaca oleracea L.), and the flowers of common lavender (Lavandula angustifolia Mill.) and silver linden (Tilia tomentosa Moench) by boiling water extraction and ethanol precipitation. The chemical composition and immunomodulating effects of isolated PSCs were characterized. The chemical characterization revealed that the three samples contain mainly pectic polysaccharides. They exhibited ex vivo intestinal immunomodulating activity through the murine Peyer's patch-mediated bone marrow cell proliferation test at 100μg/ml concentration. At the same time, they stimulated ex vivo human blood T-cell populations (CD4+/CD25+ and CD8+/CD25+), phagocytic leukocytes (CD14+ and CD64+ cells) and induced IL-6 production from human white blood cells and Peyer's patch cells. The herbal PSCs stimulated ex vivo ROS production from whole blood phagocytes and showed unspecific in vitro anti-proliferative activity against normal and A549, HeLa and LS180 tumor cells. This is the first report on immunomodulating studies of linden flower pectins and chemical and biological activity characterization of lavender polysaccharides. Our study demonstrates that similarly to purslane, lavender and silver linden herbal materials contain immunomodulating polysaccharides that could be useful for support of compromised immune system.
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- $a Batsalova, Tsvetelina G $u Department of Developmental Biology, Plovdiv University Paisii Hilendarski, 24 Tsar Assen Str., 4000 Plovdiv, Bulgaria.
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