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The identification of new substrates of human DHRS7 by molecular modeling and in vitro testing

L. Zemanová, P. Kirubakaran, IH. Pato, H. Štambergová, J. Vondrášek,

. 2017 ; 105 (Pt 1) : 171-182. [pub] 20170704

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc18033838

Human DHRS7 (SDR34C1) is one of insufficiently described enzymes of the short-chain dehydrogenase/reductase superfamily. The members of this superfamily often play an important pato/physiological role in the human body, participating in the metabolism of diverse substrates (e.g. retinoids, steroids, xenobiotics). A systematic approach to the identification of novel, physiological substrates of DHRS7 based on a combination of homology modeling, structure-based virtual screening and experimental evaluation has been used. Three novel substrates of DHRS7 (dihydrotestosterone, benzil and 4,4'-dimetylbenzil) have been described.

Citace poskytuje Crossref.org

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