Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and 13 m/5 f with nephropathy) and 26 (14 m/12 f) healthy volunteers were examined using (31)P magnetic resonance spectroscopy at 3T tomograph at rest, and during and after a calf muscle exercise. The exercise consisted of a six-minute plantar flexion using a pedal ergometer followed by a six-minute recovery. It is reflected by reduced relative beta-ATP and increased Pi and phosphodiester signals to phosphocreatine (PCr) at rest and prolongation of the PCr recovery time after the exercise. Measurement on healthy volunteers indicated differences between males and females in pH at the rest and after the exercise only. These differences between patients groups were not significant. We have proven that nephropathy affects the metabolism in diabetic patients and our results confirm significant difference between patients with and without nephropathy. Gender differences in pH were observed only between male and female healthy volunteers.

1st Medical Faculty of Charles University Prague Czech Republic

Center of Diabetology Institute for Clinical and Experimental Medicine Prague Czech Republic

MR Unit Department of Diagnostic and Interventional Radiology Institute for Clinical and Experimental Medicine Prague Czech Republic

000      

00000naa a2200000 a 4500

001      

bmc18040232

003      

CZ-PrNML

005      

20190122094537.0

007      

ta

008      

181214s2018 xr d f 000 0|eng||

009      

AR

024    7_

$a 10.33549/physiolres.933745 $2 doi

035    __

$a (PubMed)29527910

040    __

$a ABA008 $b cze $d ABA008 $e AACR2

041    0_

$a eng

044    __

$a xr

100    1_

$a Šedivý, Petr $u MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic; First Medical Faculty of Charles University, Prague, Czech Republic $7 xx0216034

245    10

$a Differences in muscle metabolism in patients with type I diabetes - influence of gender and nephropathy studied by (31)P MR spectroscopy / $c P. Sedivy, M. Dezortova, M. Drobny, Z. Vlasakova, V. Herynek, M. Hajek

520    9_

$a Type I diabetes mellitus (DM1) is a complex disease with adverse effects on organs and tissues despite compensation by insulin treatment. The goal of our study was to study how kidney diseases change (31)P MR parameters of muscle metabolism in DM1 patients with respect to gender. 51 DM1 patients (19 m/14 f without and 13 m/5 f with nephropathy) and 26 (14 m/12 f) healthy volunteers were examined using (31)P magnetic resonance spectroscopy at 3T tomograph at rest, and during and after a calf muscle exercise. The exercise consisted of a six-minute plantar flexion using a pedal ergometer followed by a six-minute recovery. It is reflected by reduced relative beta-ATP and increased Pi and phosphodiester signals to phosphocreatine (PCr) at rest and prolongation of the PCr recovery time after the exercise. Measurement on healthy volunteers indicated differences between males and females in pH at the rest and after the exercise only. These differences between patients groups were not significant. We have proven that nephropathy affects the metabolism in diabetic patients and our results confirm significant difference between patients with and without nephropathy. Gender differences in pH were observed only between male and female healthy volunteers.

650    _2

$a dospělí $7 D000328

650    _2

$a studie případů a kontrol $7 D016022

650    _2

$a diabetes mellitus 1. typu $x komplikace $x metabolismus $7 D003922

650    _2

$a diabetické nefropatie $x etiologie $x metabolismus $7 D003928

650    _2

$a energetický metabolismus $7 D004734

650    _2

$a ženské pohlaví $7 D005260

650    _2

$a lidé $7 D006801

650    _2

$a magnetická rezonanční spektroskopie $7 D009682

650    _2

$a mužské pohlaví $7 D008297

650    _2

$a lidé středního věku $7 D008875

650    _2

$a svaly $x metabolismus $7 D009132

650    _2

$a izotopy fosforu $7 D010759

650    _2

$a sexuální faktory $7 D012737

650    _2

$a mladý dospělý $7 D055815

655    _2

$a časopisecké články $7 D016428

700    1_

$a Dezortová, Monika, $d 1970- $7 xx0061339 $u MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Drobný, Miloslav $7 xx0230543 $u MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Vlasáková, Zuzana, $d 1960- $7 xx0052835 $u Center of Diabetology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Herynek, Vít, $d 1967- $7 xx0069420 $u MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

700    1_

$a Hájek, Milan, $d 1941- $7 xx0039016 $u MR-Unit, Department of Diagnostic and Interventional Radiology, Institute for Clinical and Experimental Medicine, Prague, Czech Republic

773    0_

$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 67, č. 3 (2018), s. 433-441

856    41

$u https://pubmed.ncbi.nlm.nih.gov/29527910 $y Pubmed

910    __

$a ABA008 $b A 4120 $c 266 $y 4 $z 0

990    __

$a 20181214 $b ABA008

991    __

$a 20190109125409 $b ABA008

999    __

$a ok $b bmc $g 1369655 $s 1037295

BAS    __

$a 3

BAS    __

$a PreBMC

BMC    __

$a 2018 $b 67 $c 3 $d 433-441 $e 20180312 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824

LZP    __

$b NLK118 $a Pubmed-20181214