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Circulating exosomal long noncoding RNA PRINS-First findings in monoclonal gammopathies

L. Sedlarikova, B. Bollova, L. Radova, L. Brozova, J. Jarkovsky, M. Almasi, M. Penka, P. Kuglík, V. Sandecká, M. Stork, L. Pour, S. Sevcikova,

. 2018 ; 36 (5) : 786-791. [pub] 20180913

Language English Country England, Great Britain

Document type Clinical Trial, Journal Article

Persistent link   https://www.medvik.cz/link/bmc19000425

Grant support
NV15-29508A MZ0 CEP Register

Multiple myeloma is the second most common hematological malignancy characterized by focal lesions of malignant plasma cells in the bone marrow. These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single-site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two-phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients.

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$a Multiple myeloma is the second most common hematological malignancy characterized by focal lesions of malignant plasma cells in the bone marrow. These lesions contain subclones that directly influence survival of patients. Bone marrow biopsies are single-site biopsies and thus cannot contain all information about the tumor. In contrast, liquid biopsies analyze circulating cells and molecules that are secreted from all sites of the tumor. Long noncoding RNA molecules are one class of these molecules. We performed a two-phase biomarker study investigating lncRNA expression profiles in exosomes of peripheral blood serum of newly diagnosed multiple myeloma (MM) patients, monoclonal gammopathy of undetermined significance (MGUS) patients in comparison with healthy donors (HD). Surprisingly, this analysis revealed dysregulation of only one exosomal lncRNA PRINS in MM vs HD. Overall, MM and MGUS patients were distinguished from HD with sensitivity of 84.9% and specificity of 83.3%. Our study suggests a possible diagnostic role for exosomal lncRNA PRINS in monoclonal gammopathies patients.
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$a Bollova, Bozena $u Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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$a Radova, Lenka $u Central European Institute of Technology, Masaryk University, Brno, Czech Republic.
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$a Brozova, Lucie $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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$a Jarkovský, Jiří, $d 1976- $7 stk2008461294 $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
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$a Almasi, Martina $u Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic.
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$a Penka, Miroslav $u Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic.
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$a Kuglík, Petr $u Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic.
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$a Sandecká, Viera $u Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
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$a Stork, Martin $u Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
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$a Pour, Ludek $u Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic.
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$a Sevcikova, Sabina $u Babak Myeloma Group, Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic. Department of Clinical Hematology, University Hospital Brno, Brno, Czech Republic.
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