• Something wrong with this record ?

Miniaturized microdosimeters as LET monitors: First comparison of calculated and experimental data performed at the 62 MeV/u 12C beam of INFN-LNS with four different detectors

P. Colautti, V. Conte, A. Selva, S. Chiriotti, A. Pola, D. Bortot, A. Fazzi, S. Agosteo, M. Treccani, L. De Nardo, C. Verona, GV. Rinati, G. Magrin, GAP. Cirrone, F. Romano,

. 2018 ; 52 (-) : 113-121. [pub] 20180718

Language English Country Italy

Document type Comparative Study, Journal Article

Persistent link   https://www.medvik.cz/link/bmc19000430

PURPOSE: The aim of this paper is to investigate the limits of LET monitoring of therapeutic carbon ion beams with miniaturized microdosimetric detectors. METHODS: Four different miniaturized microdosimeters have been used at the 62 MeV/u 12C beam of INFN Southern National Laboratory (LNS) of Catania for this purpose, i.e. a mini-TEPC and a GEM-microdosimeter, both filled with propane gas, and a silicon and a diamond microdosimeter. The y-D (dose-mean lineal energy) values, measured at different depths in a PMMA phantom, have been compared withLET¯D (dose-mean LET) values in water, calculated at the same water-equivalent depth with a Monte Carlo simulation setup based on the GEANT4 toolkit. RESULTS: In these first measurements, no detector was found to be significantly better than the others as a LET monitor. The y-D relative standard deviation has been assessed to be 13% for all the detectors. On average, the ratio between y-D and LET¯D values is 0.9 ± 0.3, spanning from 0.73 ± 0.08 (in the proximal edge and Bragg peak region) to 1.1 ± 0.3 at the distal edge. CONCLUSIONS: All the four microdosimeters are able to monitor the dose-mean LET with the 11% precision up to the distal edge. In the distal edge region, the ratio of y-D to LET¯D changes. Such variability is possibly due to a dependence of the detector response on depth, since the particle mean-path length inside the detectors can vary, especially in the distal edge region.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19000430
003      
CZ-PrNML
005      
20190122110401.0
007      
ta
008      
190107s2018 it f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ejmp.2018.07.004 $2 doi
035    __
$a (PubMed)30139599
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a it
100    1_
$a Colautti, P $u INFN Laboratori Nazionali di Legnaro, viale dell'Università 2, 35020 Legnaro, Italy. Electronic address: paolo.colautti@lnl.infn.it.
245    10
$a Miniaturized microdosimeters as LET monitors: First comparison of calculated and experimental data performed at the 62 MeV/u 12C beam of INFN-LNS with four different detectors / $c P. Colautti, V. Conte, A. Selva, S. Chiriotti, A. Pola, D. Bortot, A. Fazzi, S. Agosteo, M. Treccani, L. De Nardo, C. Verona, GV. Rinati, G. Magrin, GAP. Cirrone, F. Romano,
520    9_
$a PURPOSE: The aim of this paper is to investigate the limits of LET monitoring of therapeutic carbon ion beams with miniaturized microdosimetric detectors. METHODS: Four different miniaturized microdosimeters have been used at the 62 MeV/u 12C beam of INFN Southern National Laboratory (LNS) of Catania for this purpose, i.e. a mini-TEPC and a GEM-microdosimeter, both filled with propane gas, and a silicon and a diamond microdosimeter. The y-D (dose-mean lineal energy) values, measured at different depths in a PMMA phantom, have been compared withLET¯D (dose-mean LET) values in water, calculated at the same water-equivalent depth with a Monte Carlo simulation setup based on the GEANT4 toolkit. RESULTS: In these first measurements, no detector was found to be significantly better than the others as a LET monitor. The y-D relative standard deviation has been assessed to be 13% for all the detectors. On average, the ratio between y-D and LET¯D values is 0.9 ± 0.3, spanning from 0.73 ± 0.08 (in the proximal edge and Bragg peak region) to 1.1 ± 0.3 at the distal edge. CONCLUSIONS: All the four microdosimeters are able to monitor the dose-mean LET with the 11% precision up to the distal edge. In the distal edge region, the ratio of y-D to LET¯D changes. Such variability is possibly due to a dependence of the detector response on depth, since the particle mean-path length inside the detectors can vary, especially in the distal edge region.
650    _2
$a kalibrace $7 D002138
650    _2
$a izotopy uhlíku $x terapeutické užití $7 D002247
650    _2
$a počítačová simulace $7 D003198
650    _2
$a design vybavení $7 D004867
650    _2
$a radioterapie těžkými ionty $x přístrojové vybavení $7 D063193
650    _2
$a miniaturizace $7 D008904
650    _2
$a metoda Monte Carlo $7 D009010
650    _2
$a fantomy radiodiagnostické $7 D019047
650    _2
$a polymethylmethakrylát $7 D019904
650    _2
$a radiometrie $x přístrojové vybavení $7 D011874
650    _2
$a celková dávka radioterapie $7 D011879
650    _2
$a voda $7 D014867
655    _2
$a srovnávací studie $7 D003160
655    _2
$a časopisecké články $7 D016428
700    1_
$a Conte, V $u INFN Laboratori Nazionali di Legnaro, viale dell'Università 2, 35020 Legnaro, Italy.
700    1_
$a Selva, A $u INFN Laboratori Nazionali di Legnaro, viale dell'Università 2, 35020 Legnaro, Italy.
700    1_
$a Chiriotti, S $u Belgian Nuclear Research Centre, SCK·CEN, Boeretang 200, 2400 Mol, Belgium.
700    1_
$a Pola, A $u Politecnico di Milano, Dipartimento di Energia, via La Masa 34, 20156 Milano, Italy; INFN, Sezione di Milano, via Celoria 16, 20133 Milano, Italy.
700    1_
$a Bortot, D $u Politecnico di Milano, Dipartimento di Energia, via La Masa 34, 20156 Milano, Italy; INFN, Sezione di Milano, via Celoria 16, 20133 Milano, Italy.
700    1_
$a Fazzi, A $u Politecnico di Milano, Dipartimento di Energia, via La Masa 34, 20156 Milano, Italy; INFN, Sezione di Milano, via Celoria 16, 20133 Milano, Italy.
700    1_
$a Agosteo, S $u Politecnico di Milano, Dipartimento di Energia, via La Masa 34, 20156 Milano, Italy; INFN, Sezione di Milano, via Celoria 16, 20133 Milano, Italy.
700    1_
$a Treccani, M $u Politecnico di Milano, Dipartimento di Energia, via La Masa 34, 20156 Milano, Italy; INFN, Sezione di Milano, via Celoria 16, 20133 Milano, Italy.
700    1_
$a De Nardo, L $u INFN, Sezione di Padova, via Marzolo 8, 35131 Padova, Italy; University of Padova, Physics and Astronomy Department, via Marzolo 8, 35131 Padova, Italy.
700    1_
$a Verona, C $u INFN, Sezione di Roma Tor Vergata, via della Ricerca Scientifica, 1, 00133 Roma, Italy; University of Roma Tor Vergata, via del Politecnico 1, Roma 00133, Italy.
700    1_
$a Rinati, G Verona $u INFN, Sezione di Roma Tor Vergata, via della Ricerca Scientifica, 1, 00133 Roma, Italy; University of Roma Tor Vergata, via del Politecnico 1, Roma 00133, Italy.
700    1_
$a Magrin, G $u EBG MedAustron, Marie Curie-St. 5, 2700 Wiener Neustadt, Austria.
700    1_
$a Cirrone, G A P $u INFN Laboratori Nazionali del Sud, via S.Sofia 62, 95123 Catania, Italy; ELI-Beamlines, Za Radnici 835, Dolní Břežany 252 41, Czech Republic.
700    1_
$a Romano, F $u INFN Laboratori Nazionali del Sud, via S.Sofia 62, 95123 Catania, Italy; ELI-National Physical Laboratory, CMES - Medical Radiation Science, Teddington, UK.
773    0_
$w MED00167391 $t Physica medica PM an international journal devoted to the applications of physics to medicine and biology official journal of the Italian Association of Biomedical Physics (AIFB) $x 1724-191X $g Roč. 52, č. - (2018), s. 113-121
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30139599 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190107 $b ABA008
991    __
$a 20190122110621 $b ABA008
999    __
$a ok $b bmc $g 1363842 $s 1038553
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 52 $c - $d 113-121 $e 20180718 $i 1724-191X $m Physica medica $n Phys Med $x MED00167391
LZP    __
$a Pubmed-20190107

Find record

Citation metrics

Archiving options