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Polyaniline cryogels: Biocompatibility of novel conducting macroporous material
P. Humpolíček, KA. Radaszkiewicz, Z. Capáková, J. Pacherník, P. Bober, V. Kašpárková, P. Rejmontová, M. Lehocký, P. Ponížil, J. Stejskal,
Language English Country England, Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
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- MeSH
- Algorithms MeSH
- Aniline Compounds chemistry MeSH
- Biocompatible Materials chemistry MeSH
- Cell Culture Techniques MeSH
- Electric Conductivity MeSH
- Fibroblasts MeSH
- Cryogels chemistry MeSH
- Mechanical Phenomena MeSH
- Elastic Modulus MeSH
- Mice MeSH
- Porosity MeSH
- Models, Theoretical MeSH
- Materials Testing MeSH
- Tissue Engineering MeSH
- Cell Survival MeSH
- Chromatography, High Pressure Liquid MeSH
- Animals MeSH
- Check Tag
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Polyaniline cryogel is a new unique form of polyaniline combining intrinsic electrical conductivity and the material properties of hydrogels. It is prepared by the polymerization of aniline in frozen poly(vinyl alcohol) solutions. The biocompatibility of macroporous polyaniline cryogel was demonstrated by testing its cytotoxicity on mouse embryonic fibroblasts and via the test of embryotoxicity based on the formation of beating foci within spontaneous differentiating embryonic stem cells. Good biocompatibility was related to low contents of low-molecular-weight impurities in polyaniline cryogel, which was confirmed by liquid chromatography. The adhesion and growth of embryonic stem cells, embryoid bodies, cardiomyocytes, and neural progenitors prove that polyaniline cryogel has the potential to be used as a carrier for cells in tissue engineering or bio-sensing. The surface energy as well as the elasticity and porosity of cryogel mimic tissue properties. Polyaniline cryogel can therefore be applied in bio-sensing or regenerative medicine in general, and mainly in the tissue engineering of electrically excitable tissues.
Centre of Polymer Systems Tomas Bata University in Zlin 760 01 Zlin Czech Republic
Institute of Experimental Biology Faculty of Science Masaryk University 625 00 Brno Czech Republic
References provided by Crossref.org
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