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Impact of stress on the gut microbiome of free-ranging western lowland gorillas
K. Vlčková, K. Shutt-Phillips, M. Heistermann, B. Pafčo, KJ. Petrželková, A. Todd, D. Modrý, KE. Nelson, BA. Wilson, RM. Stumpf, BA. White, SR. Leigh, A. Gomez,
Language English Country England, Great Britain
Document type Journal Article
PubMed
29205130
DOI
10.1099/mic.0.000587
Knihovny.cz E-resources
- MeSH
- Bacteria classification genetics MeSH
- DNA, Bacterial MeSH
- Feces chemistry microbiology MeSH
- Stress, Physiological * MeSH
- Glucocorticoids analysis MeSH
- Gorilla gorilla microbiology physiology MeSH
- RNA, Ribosomal, 16S MeSH
- Sequence Analysis, DNA MeSH
- Models, Statistical MeSH
- Gastrointestinal Microbiome physiology MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
Exposure to stressors can negatively impact the mammalian gastrointestinal microbiome (GIM). Here, we used 454 pyrosequencing of 16S rRNA bacterial gene amplicons to evaluate the impact of physiological stress, as evidenced by faecal glucocorticoid metabolites (FGCM; ng/g), on the GIM composition of free-ranging western lowland gorillas (Gorilla gorilla gorilla). Although we found no relationship between GIM alpha diversity (H) and FGCM levels, we observed a significant relationship between the relative abundances of particular bacterial taxa and FGCM levels. Specifically, members of the family Anaerolineaceae (ρ=0.4, FDR q=0.01), genus Clostridium cluster XIVb (ρ=0.35, FDR q=0.02) and genus Oscillibacter (ρ=0.35, FDR q=0.02) were positively correlated with FGCM levels. Thus, while exposure to stressors appears to be associated with minor changes in the gorilla GIM, the consequences of these changes are unknown. Our results may have implications for conservation biology as well as for our overall understanding of factors influencing the non-human primate GIM.
Department of Animal Science University of Minnesota 1364 Eckles Aneue St Paul MN 55108 6118 USA
Fauna and Flora International Pembroke Street Cambridge CB2 3QZ UK
German Primate Centre Endocrinology Laboratory Kellnerweg 4 37077 Göttingen Germany
WWF Dzanga Sangha Protected Areas BP 1053 Bangui Central African Republic
References provided by Crossref.org
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- $a Vlčková, Klára $u 1Department of Pathology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, Brno 61242, Czech Republic. 2Institute of Vertebrate Biology, Czech Academy of Sciences, Květná 8, Brno 60365, Czech Republic.
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- $a Impact of stress on the gut microbiome of free-ranging western lowland gorillas / $c K. Vlčková, K. Shutt-Phillips, M. Heistermann, B. Pafčo, KJ. Petrželková, A. Todd, D. Modrý, KE. Nelson, BA. Wilson, RM. Stumpf, BA. White, SR. Leigh, A. Gomez,
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- $a Exposure to stressors can negatively impact the mammalian gastrointestinal microbiome (GIM). Here, we used 454 pyrosequencing of 16S rRNA bacterial gene amplicons to evaluate the impact of physiological stress, as evidenced by faecal glucocorticoid metabolites (FGCM; ng/g), on the GIM composition of free-ranging western lowland gorillas (Gorilla gorilla gorilla). Although we found no relationship between GIM alpha diversity (H) and FGCM levels, we observed a significant relationship between the relative abundances of particular bacterial taxa and FGCM levels. Specifically, members of the family Anaerolineaceae (ρ=0.4, FDR q=0.01), genus Clostridium cluster XIVb (ρ=0.35, FDR q=0.02) and genus Oscillibacter (ρ=0.35, FDR q=0.02) were positively correlated with FGCM levels. Thus, while exposure to stressors appears to be associated with minor changes in the gorilla GIM, the consequences of these changes are unknown. Our results may have implications for conservation biology as well as for our overall understanding of factors influencing the non-human primate GIM.
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- $a Pafčo, Barbora $u 1Department of Pathology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, Brno 61242, Czech Republic.
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- $a Petrželková, Klára J $u 2Institute of Vertebrate Biology, Czech Academy of Sciences, Květná 8, Brno 60365, Czech Republic. 5Liberec Zoo, Masarykova 1347/31, Liberec, 46001, Czech Republic. 6Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 31, České Budějovice, 37005, Czech Republic.
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- $a Todd, Angelique $u 7WWF, Dzanga Sangha Protected Areas, BP 1053 Bangui, Central African Republic.
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- $a Modrý, David $u 1Department of Pathology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, Brno 61242, Czech Republic. 6Institute of Parasitology, Biology Centre of the Czech Academy of Sciences, Branišovská 31, České Budějovice, 37005, Czech Republic. 8CEITEC VFU, University of Veterinary and Pharmaceutical Sciences Brno, Palackého tř. 1946/1, Brno, 61242, Czech Republic.
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- $a Nelson, Karen E $u 9J. Craig Venter Institute, 9714 Medical Center Drive, Rockville, MD 20850, USA. 10J. Craig Venter Institute, 4120 Capricorn Lane, La Jolla, CA 92037, USA.
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- $a Wilson, Brenda A $u 11Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA. 12Department of Microbiology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA.
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- $a Stumpf, Rebecca M $u 12Department of Microbiology, University of Illinois at Urbana-Champaign, 601 South Goodwin Avenue, Urbana, IL 61801, USA. 13Department of Anthropology, University of Illinois at Urbana-Champaign, 607 South Mathews Avenue, Urbana, IL 61801, USA.
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- $a White, Bryan A $u 11Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA.
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- $a Leigh, Steven R $u 11Carl R. Woese Institute for Genomic Biology, University of Illinois at Urbana-Champaign, 1206 West Gregory Drive, Urbana, IL 61801, USA. 14Department of Anthropology, University of Colorado at Boulder, 1350 Pleasant Street, Boulder, CO 80309-0233, USA.
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- $a Gomez, Andres $u 15Department of Animal Science, University of Minnesota, 1364 Eckles Aneue, St Paul, MN 55108-6118, USA.
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