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FLIM analysis of intracellular markers associated with the development of Parkinson's disease in cellular model
M. Pokusa, A. Kráľová Trančíková
Language English Country Czech Republic
Document type Journal Article
NLK
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ProQuest Central
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- MeSH
- alpha-Synuclein metabolism MeSH
- Biomarkers metabolism MeSH
- Inclusion Bodies metabolism pathology MeSH
- Intracellular Fluid metabolism MeSH
- Humans MeSH
- Membrane Potential, Mitochondrial physiology MeSH
- Mitochondria metabolism pathology MeSH
- NAD metabolism MeSH
- Cell Line, Tumor MeSH
- Optical Imaging methods MeSH
- Parkinson Disease metabolism pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Parkinson's disease (PD) is currently the second most common neurodegenerative disorder in the world. Major features of cell pathology of the disease include the presence of cytoplasmic inclusions called Lewy bodies, which are composed of aggregated proteins. The presence of Lewy's body is associated with more advanced stages of the disease when considering irreversible changes. Precise identification of the disease stage at a cellular level presents the critical tool in developing early diagnostics and/or prevention of PD. The aim of our work is to introduce sensitive microscopic analysis in living cells, focused on initial intracellular changes and thus capable to detect earlier stages of the disease.
References provided by Crossref.org
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