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Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations

G. Petringa, F. Romano, L. Manti, L. Pandola, A. Attili, F. Cammarata, G. Cuttone, G. Forte, L. Manganaro, J. Pipek, P. Pisciotta, G. Russo, GAP. Cirrone,

. 2019 ; 58 (-) : 72-80. [pub] 20190205

Language English Country Italy

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19011901

PURPOSE: The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. METHODS: The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. RESULTS AND CONCLUSIONS: The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.

References provided by Crossref.org

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$a Petringa, G $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; Dipartimento di Fisica e Astronomia, Universitá degli Studi di Catania, Via S. Sofia 64, 95123 Catania, Italy.
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$a Radiobiological quantities in proton-therapy: Estimation and validation using Geant4-based Monte Carlo simulations / $c G. Petringa, F. Romano, L. Manti, L. Pandola, A. Attili, F. Cammarata, G. Cuttone, G. Forte, L. Manganaro, J. Pipek, P. Pisciotta, G. Russo, GAP. Cirrone,
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$a PURPOSE: The Geant4 Monte Carlo simulation toolkit was used to reproduce radiobiological parameters measured by irradiating three different cancerous cell lines with monochromatic and clinical proton beams. METHODS: The experimental set-up adopted for irradiations was fully simulated with a dedicated open-source Geant4 application. Cells survival fractions was calculated coupling the Geant4 simulations with two analytical radiobiological models: one based on the LEM (Local Effect Model) approach and the other on a semi-empirical parameterisation. Results was evaluated and compared with experimental data. RESULTS AND CONCLUSIONS: The results demonstrated the Geant4 ability to reproduce radiobiological quantities for different cell lines.
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$a Romano, F $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; National Physical Laboratory, Acoustic and Ionizing Radiation Division, Teddington TW11 0LW, Middlesex, UK.
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$a Manti, L $u Dipartimento di Fisica E. Pancini, Universitá degli Studi Federico II di Napoli, Via Cinthia, I-80126 Napoli, Italy; INFN-NA, Istituto Nazionale di Fisica Nucleare, Sezione di Napoli, Complesso Universitario di M. S. Angelo, Via Cintia, I-80126 Napoli, Italy.
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$a Pandola, L $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy.
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$a Attili, A $u INFN-TO, Istituto Nazionale di Fisica Nucleare, Sezione di Torino, Torino, Italy.
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$a Cammarata, F $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; IBFM-CNR, Institute of Molecular Bioimaging and Physiology - National Research Council, Cefalù, PA, Italy.
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$a Cuttone, G $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy.
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$a Forte, G $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; IBFM-CNR, Institute of Molecular Bioimaging and Physiology - National Research Council, Cefalù, PA, Italy.
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$a Manganaro, L $u INFN-TO, Istituto Nazionale di Fisica Nucleare, Sezione di Torino, Torino, Italy.
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$a Pipek, J $u ELI-Beamline Project, Inst. Physics, ASCR, PALS Center, Prague, Czech Republic.
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$a Pisciotta, P $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; Dipartimento di Fisica e Astronomia, Universitá degli Studi di Catania, Via S. Sofia 64, 95123 Catania, Italy.
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$a Russo, G $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; IBFM-CNR, Institute of Molecular Bioimaging and Physiology - National Research Council, Cefalù, PA, Italy.
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$a Cirrone, G A P $u INFN-LNS. Istituto Nazionale di Fisica Nucleare - Laboratori Nazionali del Sud, Via S. Sofia 62, 95123 Catania, Italy; ELI-Beamline Project, Inst. Physics, ASCR, PALS Center, Prague, Czech Republic. Electronic address: pablo.cirrone@lns.infn.it.
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