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Electrical Stimulation Modulates High γ Activity and Human Memory Performance
MT. Kucewicz, BM. Berry, V. Kremen, LR. Miller, F. Khadjevand, Y. Ezzyat, JM. Stein, P. Wanda, MR. Sperling, R. Gorniak, KA. Davis, BC. Jobst, RE. Gross, B. Lega, SM. Stead, DS. Rizzuto, MJ. Kahana, GA. Worrell,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem, Research Support, U.S. Gov't, Non-P.H.S.
PubMed Central od 2014
Europe PubMed Central od 2014
Open Access Digital Library od 2014-01-01
ROAD: Directory of Open Access Scholarly Resources od 2014
Odkazy
PubMed
29404403
DOI
10.1523/eneuro.0369-17.2018
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- elektrická stimulace * MeSH
- elektrokortikografie * MeSH
- gama rytmus EEG fyziologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mozková kůra fyziologie MeSH
- paměť fyziologie MeSH
- refrakterní epilepsie patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, Non-P.H.S. MeSH
Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC). Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high γ (62-118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with "poor" memory encoding. The high γ modulation correlated with the behavioral effect of stimulation in a given brain region: it was negative, i.e., the induced high γ activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral TC where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high γ activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.
Department of Neurology Dartmouth Hitchcock Medical Center Lebanon NH 03756
Department of Neurology Hospital of the University of Pennsylvania Philadelphia PA 19104
Department of Neurology Thomas Jefferson University Hospital Philadelphia PA 19107
Department of Neurosurgery Emory University Atlanta GA 30307
Department of Neurosurgery UT Southwestern Medical Center Dallas TX 75390
Department of Psychology Hospital of the University of Pennsylvania Philadelphia PA 19104
Department of Radiology Hospital of the University of Pennsylvania Philadelphia PA 19104
Department of Radiology Thomas Jefferson University Hospital Philadelphia PA 19107
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- $a Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC). Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high γ (62-118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with "poor" memory encoding. The high γ modulation correlated with the behavioral effect of stimulation in a given brain region: it was negative, i.e., the induced high γ activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral TC where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high γ activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.
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