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Electrical Stimulation Modulates High γ Activity and Human Memory Performance

MT. Kucewicz, BM. Berry, V. Kremen, LR. Miller, F. Khadjevand, Y. Ezzyat, JM. Stein, P. Wanda, MR. Sperling, R. Gorniak, KA. Davis, BC. Jobst, RE. Gross, B. Lega, SM. Stead, DS. Rizzuto, MJ. Kahana, GA. Worrell,

. 2018 ; 5 (1) : . [pub] 20180202

Language English Country United States

Document type Journal Article, Multicenter Study, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.

Persistent link   https://www.medvik.cz/link/bmc19012868

Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC). Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high γ (62-118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with "poor" memory encoding. The high γ modulation correlated with the behavioral effect of stimulation in a given brain region: it was negative, i.e., the induced high γ activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral TC where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high γ activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.

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$a Direct electrical stimulation of the brain has emerged as a powerful treatment for multiple neurological diseases, and as a potential technique to enhance human cognition. Despite its application in a range of brain disorders, it remains unclear how stimulation of discrete brain areas affects memory performance and the underlying electrophysiological activities. Here, we investigated the effect of direct electrical stimulation in four brain regions known to support declarative memory: hippocampus (HP), parahippocampal region (PH) neocortex, prefrontal cortex (PF), and lateral temporal cortex (TC). Intracranial EEG recordings with stimulation were collected from 22 patients during performance of verbal memory tasks. We found that high γ (62-118 Hz) activity induced by word presentation was modulated by electrical stimulation. This modulatory effect was greatest for trials with "poor" memory encoding. The high γ modulation correlated with the behavioral effect of stimulation in a given brain region: it was negative, i.e., the induced high γ activity was decreased, in the regions where stimulation decreased memory performance, and positive in the lateral TC where memory enhancement was observed. Our results suggest that the effect of electrical stimulation on high γ activity induced by word presentation may be a useful biomarker for mapping memory networks and guiding therapeutic brain stimulation.
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$a Berry, Brent M $u Department of Neurology, Mayo Clinic, Rochester, MN 55905. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905.
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$a Miller, Laura R $u Department of Neurology, Mayo Clinic, Rochester, MN 55905. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905.
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$a Ezzyat, Youssef $u Department of Psychology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
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$a Sperling, Michael R $u Department of Neurology, Thomas Jefferson University Hospital, Philadelphia, PA 19107.
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$a Gross, Robert E $u Department of Neurosurgery, Emory University, Atlanta, GA 30307.
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$a Lega, Bradley $u Department of Neurosurgery, UT Southwestern Medical Center, Dallas, TX 75390.
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$a Rizzuto, Daniel S $u Department of Psychology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104.
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$a Worrell, Gregory A $u Department of Neurology, Mayo Clinic, Rochester, MN 55905. Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905.
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