-
Je něco špatně v tomto záznamu ?
Analysis of Real-world Data on Postremission Therapy for Acute Myeloid Leukemia With Intermediate Risk Cytogenetics in First Complete Remission
J. Vydra, C. Šálek, J. Schwarz, P. Žák, J. Novák, V. Petečuková, P. Pecherková, J. Mayer, P. Cetkovský, Z. Ráčil,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NV15-25809A
MZ0
CEP - Centrální evidence projektů
- MeSH
- akutní nemoc MeSH
- celotělové ozáření MeSH
- cytarabin terapeutické užití MeSH
- dospělí MeSH
- hodnocení výsledků zdravotní péče metody statistika a číselné údaje MeSH
- homologní transplantace MeSH
- indukce remise MeSH
- kombinovaná terapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- myeloidní leukemie genetika patologie terapie MeSH
- přežití bez známek nemoci MeSH
- příprava pacienta k transplantaci metody MeSH
- proporcionální rizikové modely MeSH
- protinádorové antimetabolity terapeutické užití MeSH
- retrospektivní studie MeSH
- transplantace hematopoetických kmenových buněk metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: We retrospectively analyzed data from 310 patients with acute myeloid leukemia with intermediate-risk cytogenetics in first complete remission (CR1) to evaluate the usage and efficacy of various types of postremission therapy. PATIENTS AND METHODS: Cox regression with time-dependent covariates, landmark analysis, and competing risk models were used to estimate the outcomes and effects of treatment and patient- and disease-related risk factors. RESULTS: The early relapse rate and early nonrelapse mortality (NRM) were 12.8% and 4.4%, respectively. In our study, 77.2% of patients completed postremission therapy: 44% received allogeneic hematopoietic cell transplantation (HCT), 20% completed treatment with high-dose cytarabine (HIDAC), and 13% completed treatment with intermediate-dose cytarabine. The 3-year overall survival rate was 67.5% for patients treated with HIDAC and 63.4% after HCT (P = .5876). The NRM and relapse rate at 3 years were 0% and 58.9% after HIDAC and 21.9% and 29.3% after HCT, respectively. HCT reduced the risk of relapse (hazard ratio, 0.6; 95% confidence interval, 0.36-0.98). Total body irradiation-based myeloablative conditioning increased NRM compared with busulfan-based conditioning (hazard ratio, 8.33; 95% confidence interval, 2.52-27.45). CONCLUSION: Most patients with acute myeloid leukemia with intermediate-risk cytogenetics received allogeneic HCT, which decreased the risk of relapse but increased NRM, leading to a similar overall survival for patients who received HCT and HIDAC. Our data support the use of allogeneic transplantation for patients in CR1 from a human leukocyte antigen-matched related or unrelated donor after a busulfan-based myeloablative conditioning regimen as a primary strategy of postremission therapy for eligible younger patients.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19012955
- 003
- CZ-PrNML
- 005
- 20231102133850.0
- 007
- ta
- 008
- 190405s2018 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.clml.2017.11.011 $2 doi
- 035 __
- $a (PubMed)29289481
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Vydra, Jan $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic; Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic. Electronic address: jan.vydra@uhkt.cz.
- 245 10
- $a Analysis of Real-world Data on Postremission Therapy for Acute Myeloid Leukemia With Intermediate Risk Cytogenetics in First Complete Remission / $c J. Vydra, C. Šálek, J. Schwarz, P. Žák, J. Novák, V. Petečuková, P. Pecherková, J. Mayer, P. Cetkovský, Z. Ráčil,
- 520 9_
- $a BACKGROUND: We retrospectively analyzed data from 310 patients with acute myeloid leukemia with intermediate-risk cytogenetics in first complete remission (CR1) to evaluate the usage and efficacy of various types of postremission therapy. PATIENTS AND METHODS: Cox regression with time-dependent covariates, landmark analysis, and competing risk models were used to estimate the outcomes and effects of treatment and patient- and disease-related risk factors. RESULTS: The early relapse rate and early nonrelapse mortality (NRM) were 12.8% and 4.4%, respectively. In our study, 77.2% of patients completed postremission therapy: 44% received allogeneic hematopoietic cell transplantation (HCT), 20% completed treatment with high-dose cytarabine (HIDAC), and 13% completed treatment with intermediate-dose cytarabine. The 3-year overall survival rate was 67.5% for patients treated with HIDAC and 63.4% after HCT (P = .5876). The NRM and relapse rate at 3 years were 0% and 58.9% after HIDAC and 21.9% and 29.3% after HCT, respectively. HCT reduced the risk of relapse (hazard ratio, 0.6; 95% confidence interval, 0.36-0.98). Total body irradiation-based myeloablative conditioning increased NRM compared with busulfan-based conditioning (hazard ratio, 8.33; 95% confidence interval, 2.52-27.45). CONCLUSION: Most patients with acute myeloid leukemia with intermediate-risk cytogenetics received allogeneic HCT, which decreased the risk of relapse but increased NRM, leading to a similar overall survival for patients who received HCT and HIDAC. Our data support the use of allogeneic transplantation for patients in CR1 from a human leukocyte antigen-matched related or unrelated donor after a busulfan-based myeloablative conditioning regimen as a primary strategy of postremission therapy for eligible younger patients.
- 650 _2
- $a akutní nemoc $7 D000208
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a protinádorové antimetabolity $x terapeutické užití $7 D000964
- 650 _2
- $a kombinovaná terapie $7 D003131
- 650 _2
- $a cytarabin $x terapeutické užití $7 D003561
- 650 _2
- $a přežití bez známek nemoci $7 D018572
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a transplantace hematopoetických kmenových buněk $x metody $7 D018380
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a myeloidní leukemie $x genetika $x patologie $x terapie $7 D007951
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a hodnocení výsledků zdravotní péče $x metody $x statistika a číselné údaje $7 D017063
- 650 _2
- $a proporcionální rizikové modely $7 D016016
- 650 _2
- $a indukce remise $7 D012074
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a příprava pacienta k transplantaci $x metody $7 D019172
- 650 _2
- $a homologní transplantace $7 D014184
- 650 _2
- $a celotělové ozáření $7 D014916
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 700 1_
- $a Šálek, Cyril $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
- 700 1_
- $a Schwarz, Jiří $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
- 700 1_
- $a Žák, Pavel $u Fourth Department of Medicine - Haematology, University Hospital Hradec Králové and Charles University, Hradec Králové, Czech Republic.
- 700 1_
- $a Novák, Jan $u Department of Internal Medicine - Hematology, Third Medical School, University Hospital Královské Vinohrady and Charles University, Prague, Czech Republic.
- 700 1_
- $a Petečuková, Veronika $7 xx0240382 $u Department of Internal Medicine - Hematology, Third Medical School, University Hospital Královské Vinohrady and Charles University, Prague, Czech Republic.
- 700 1_
- $a Pecherková, Pavla, $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic. $d 1980- $7 ctu2013787641
- 700 1_
- $a Mayer, Jiří $u Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
- 700 1_
- $a Cetkovský, Petr $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
- 700 1_
- $a Ráčil, Zdeněk $u Department of Internal Medicine, Hematology and Oncology, Masaryk University and University Hospital Brno, Brno, Czech Republic.
- 773 0_
- $w MED00180199 $t Clinical lymphoma, myeloma & leukemia $x 2152-2669 $g Roč. 18, č. 2 (2018), s. 106-113
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29289481 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20190405 $b ABA008
- 991 __
- $a 20231102133844 $b ABA008
- 999 __
- $a ok $b bmc $g 1392265 $s 1051260
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 18 $c 2 $d 106-113 $e 20171207 $i 2152-2669 $m Clinical lymphoma, myeloma & leukemia $n Clin Lymphoma Myeloma Leuk $x MED00180199
- GRA __
- $a NV15-25809A $p MZ0
- LZP __
- $a Pubmed-20190405
