• Something wrong with this record ?

Wild rodents and shrews are natural hosts of Staphylococcus aureus

DM. Mrochen, D. Schulz, S. Fischer, K. Jeske, H. El Gohary, D. Reil, C. Imholt, P. Trübe, J. Suchomel, E. Tricaud, J. Jacob, M. Heroldová, BM. Bröker, B. Strommenger, B. Walther, RG. Ulrich, S. Holtfreter,

. 2018 ; 308 (6) : 590-597. [pub] 20170922

Language English Country Germany

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19013069

Laboratory mice are the most commonly used animal model for Staphylococcus aureus infection studies. We have previously shown that laboratory mice from global vendors are frequently colonized with S. aureus. Laboratory mice originate from wild house mice. Hence, we investigated whether wild rodents, including house mice, as well as shrews are naturally colonized with S. aureus and whether S. aureus adapts to the wild animal host. 295 animals of ten different species were caught in different locations over four years (2012-2015) in Germany, France and the Czech Republic. 45 animals were positive for S. aureus (15.3%). Three animals were co-colonized with two different isolates, resulting in 48 S. aureus isolates in total. Positive animals were found in Germany and the Czech Republic in each studied year. The S. aureus isolates belonged to ten different spa types, which grouped into six lineages (clonal complex (CC) 49, CC88, CC130, CC1956, sequence type (ST) 890, ST3033). CC49 isolates were most abundant (17/48, 35.4%), followed by CC1956 (14/48, 29.2%) and ST890 (9/48, 18.8%). The wild animal isolates lacked certain properties that are common among human isolates, e.g., a phage-encoded immune evasion cluster, superantigen genes on mobile genetic elements and antibiotic resistance genes, which suggests long-term adaptation to the wild animal host. One CC130 isolate contained the mecC gene, implying wild rodents might be both reservoir and vector for methicillin-resistant . In conclusion, we demonstrated that wild rodents and shrews are naturally colonized with S. aureus, and that those S. aureus isolates show signs of host adaptation.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19013069
003      
CZ-PrNML
005      
20190412095158.0
007      
ta
008      
190405s2018 gw f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.ijmm.2017.09.014 $2 doi
035    __
$a (PubMed)28967544
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gw
100    1_
$a Mrochen, Daniel M $u Department of Immunology, University Medicine Greifswald, Sauerbruchstraße DZ7, 17475 Greifswald, Germany.
245    10
$a Wild rodents and shrews are natural hosts of Staphylococcus aureus / $c DM. Mrochen, D. Schulz, S. Fischer, K. Jeske, H. El Gohary, D. Reil, C. Imholt, P. Trübe, J. Suchomel, E. Tricaud, J. Jacob, M. Heroldová, BM. Bröker, B. Strommenger, B. Walther, RG. Ulrich, S. Holtfreter,
520    9_
$a Laboratory mice are the most commonly used animal model for Staphylococcus aureus infection studies. We have previously shown that laboratory mice from global vendors are frequently colonized with S. aureus. Laboratory mice originate from wild house mice. Hence, we investigated whether wild rodents, including house mice, as well as shrews are naturally colonized with S. aureus and whether S. aureus adapts to the wild animal host. 295 animals of ten different species were caught in different locations over four years (2012-2015) in Germany, France and the Czech Republic. 45 animals were positive for S. aureus (15.3%). Three animals were co-colonized with two different isolates, resulting in 48 S. aureus isolates in total. Positive animals were found in Germany and the Czech Republic in each studied year. The S. aureus isolates belonged to ten different spa types, which grouped into six lineages (clonal complex (CC) 49, CC88, CC130, CC1956, sequence type (ST) 890, ST3033). CC49 isolates were most abundant (17/48, 35.4%), followed by CC1956 (14/48, 29.2%) and ST890 (9/48, 18.8%). The wild animal isolates lacked certain properties that are common among human isolates, e.g., a phage-encoded immune evasion cluster, superantigen genes on mobile genetic elements and antibiotic resistance genes, which suggests long-term adaptation to the wild animal host. One CC130 isolate contained the mecC gene, implying wild rodents might be both reservoir and vector for methicillin-resistant . In conclusion, we demonstrated that wild rodents and shrews are naturally colonized with S. aureus, and that those S. aureus isolates show signs of host adaptation.
650    _2
$a zvířata $7 D000818
650    _2
$a divoká zvířata $x mikrobiologie $7 D000835
650    _2
$a antibakteriální látky $x farmakologie $7 D000900
650    _2
$a bakteriální proteiny $x genetika $7 D001426
650    _2
$a methicilin rezistentní Staphylococcus aureus $7 D055624
650    _2
$a myši $7 D051379
650    _2
$a mikrobiální testy citlivosti $7 D008826
650    _2
$a hlodavci $x mikrobiologie $7 D012377
650    _2
$a rejskovití $x mikrobiologie $7 D012788
650    _2
$a stafylokokové infekce $x epidemiologie $x veterinární $7 D013203
650    _2
$a Staphylococcus aureus $x klasifikace $x izolace a purifikace $7 D013211
650    _2
$a faktory virulence $x genetika $7 D037521
651    _2
$a Česká republika $x epidemiologie $7 D018153
651    _2
$a Francie $x epidemiologie $7 D005602
651    _2
$a Německo $x epidemiologie $7 D005858
655    _2
$a časopisecké články $7 D016428
700    1_
$a Schulz, Daniel $u Department of Immunology, University Medicine Greifswald, Sauerbruchstraße DZ7, 17475 Greifswald, Germany.
700    1_
$a Fischer, Stefan $u Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
700    1_
$a Jeske, Kathrin $u Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
700    1_
$a El Gohary, Heba $u Department of Immunology, University Medicine Greifswald, Sauerbruchstraße DZ7, 17475 Greifswald, Germany.
700    1_
$a Reil, Daniela $u Institute for Plant Protection in Horticulture and Forests, Vertebrate Research, Julius Kühn-Institute, Federal Research Centre for Cultivated Plants, Toppheideweg 88, 48161 Münster, Germany.
700    1_
$a Imholt, Christian $u Institute for Plant Protection in Horticulture and Forests, Vertebrate Research, Julius Kühn-Institute, Federal Research Centre for Cultivated Plants, Toppheideweg 88, 48161 Münster, Germany.
700    1_
$a Trübe, Patricia $u Department of Immunology, University Medicine Greifswald, Sauerbruchstraße DZ7, 17475 Greifswald, Germany.
700    1_
$a Suchomel, Josef $u Department of Zoology, Fisheries, Hydrobiology and Apiculture, Faculty of Agronomy, Mendel University in Brno, Zemědělská 1, 61300 Brno, Czech Republic.
700    1_
$a Tricaud, Emilie $u Institut Claude Bourgelat, Laboratoire de Toxicologie, BIOLYTICS, 1 Avenue Bourgelat, 69280 Marcy-l'Étoile, France.
700    1_
$a Jacob, Jens $u Institute for Plant Protection in Horticulture and Forests, Vertebrate Research, Julius Kühn-Institute, Federal Research Centre for Cultivated Plants, Toppheideweg 88, 48161 Münster, Germany.
700    1_
$a Heroldová, Marta $u Department of Forest Ecology, Mendel University in Brno, Zemědělská 3, 61300 Brno, Czech Republic.
700    1_
$a Bröker, Barbara M $u Department of Immunology, University Medicine Greifswald, Sauerbruchstraße DZ7, 17475 Greifswald, Germany.
700    1_
$a Strommenger, Birgit $u National Reference Centre for Staphylococci and Enterococci, Division Nosocomial Pathogens and Antibiotic Resistances, Department of Infectious Diseases, Robert Koch-Institut, Burgstraße 37, 38855 Wernigerode, Germany.
700    1_
$a Walther, Birgit $u Institute of Microbiology and Epizootics, Veterinary Faculty, Freie Universität Berlin, Robert-von-Ostertag Straße 7-13, 14163 Berlin, Germany.
700    1_
$a Ulrich, Rainer G $u Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Südufer 10, 17493 Greifswald-Insel Riems, Germany.
700    1_
$a Holtfreter, Silva $u Department of Immunology, University Medicine Greifswald, Sauerbruchstraße DZ7, 17475 Greifswald, Germany. Electronic address: silva.holtfreter@uni-greifswald.de.
773    0_
$w MED00005699 $t International journal of medical microbiology IJMM $x 1618-0607 $g Roč. 308, č. 6 (2018), s. 590-597
856    41
$u https://pubmed.ncbi.nlm.nih.gov/28967544 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20190412095217 $b ABA008
999    __
$a ok $b bmc $g 1392379 $s 1051374
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 308 $c 6 $d 590-597 $e 20170922 $i 1618-0607 $m International journal of medical microbiology $n Int J Med Microbiol $x MED00005699
LZP    __
$a Pubmed-20190405

Find record

Citation metrics

Archiving options