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Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
L. Hou, SE. Bergen, N. Akula, J. Song, CM. Hultman, M. Landén, M. Adli, M. Alda, R. Ardau, B. Arias, JM. Aubry, L. Backlund, JA. Badner, TB. Barrett, M. Bauer, BT. Baune, F. Bellivier, A. Benabarre, S. Bengesser, WH. Berrettini, AK....
Human molecular genetics.
2016 ;
25 (15) :
3383-3394.
[pub] 20160621
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, metaanalýza
Perzistentní odkaz
https://www.medvik.cz/link/bmc19013198
Online
Plný text
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
PubMed
27329760
DOI
10.1093/hmg/ddw181
Knihovny.cz E-zdroje
- MeSH
- bipolární porucha genetika MeSH
- celogenomová asociační studie * MeSH
- lidé MeSH
- lidské chromozomy X genetika MeSH
- receptor erbB-2 genetika MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- metaanalýza MeSH
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behaviour. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ∼2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the X-chromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, P = 5.87 × 10 - 9; odds ratio (OR) = 1.12) and markers within ERBB2 (rs2517959, P = 4.53 × 10 - 9; OR = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
Bipolar Center Wiener Neustadt Wiener Neustadt Austria and
Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Biomedical Sciences University of Cagliari Cagliari Italy
Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Mental Health Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
Department of Pharmacy VA San Diego Healthcare System San Diego CA USA
Department of Psychiatry and Behavioral Neuroscience University of Chicago Chicago IL USA
Department of Psychiatry and Behavioral Sciences Howard University Hospital Washington DC USA
Department of Psychiatry and Behavioral Sciences Johns Hopkins School of Medicine Baltimore MD USA
Department of Psychiatry and Psychology Mayo Clinic Rochester MN USA
Department of Psychiatry and Psychotherapy Ludwig Maximilians University Munich Munich Germany
Department of Psychiatry Dalhousie University Halifax Canada
Department of Psychiatry Indiana University School of Medicine Indianapolis IN USA
Department of Psychiatry University of Bonn Germany
Department of Psychiatry University of California at San Francisco San Francisco CA USA
Department of Psychiatry University of California San Diego San Diego CA USA
Department of Psychiatry University of Illinois at Chicago Chicago IL USA
Department of Psychiatry University of Michigan Ann Arbor MI USA
Department of Psychiatry University of Naples SUN Naples Italy
Department of Psychiatry University of Pennsylvania Philadelphia PA USA
Department of Psychiatry VA San Diego Healthcare System San Diego CA USA
Department of Psychiatry Washington University School of Medicine in St Louis
Discipline of Psychiatry University of Adelaide Adelaide Australia
Douglas Mental Health University Institute McGill University Montreal Canada
Institute of Human Genetics University of Bonn Germany
Lindner Center of HOPE University of Cincinnati College of Medicine Mason OH USA
McGill University Health Centre Mood Disorders Program Montreal QC Canada
Montreal Neurological Institute and Hospital McGill University Montreal Canada
National Institute of Mental Health Klecany Czech Republic
Portland Veterans Affairs Medical Center Portland OR USA
Psychiatric Genetic Unit Poznan University of Medical Sciences Poznan Poland
Rush University Medical Center Chicago IL USA
School of Psychiatry University of New South Wales and Black Dog Institute Sydney Australia
Scripps Translational Science Institute La Jolla CA USA
Service de Psychiatrie Hôpital Charles Perrens Bordeaux France
Special Outpatient Center for Bipolar Affective Disorder Medical University of Graz Graz Austria
The Translational Genomics Research Institute Phoenix AZ USA
Unit of Clinical Pharmacology Hospital University Agency of Cagliari Cagliari Italy
Citace poskytuje Crossref.org
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- $a Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder / $c L. Hou, SE. Bergen, N. Akula, J. Song, CM. Hultman, M. Landén, M. Adli, M. Alda, R. Ardau, B. Arias, JM. Aubry, L. Backlund, JA. Badner, TB. Barrett, M. Bauer, BT. Baune, F. Bellivier, A. Benabarre, S. Bengesser, WH. Berrettini, AK. Bhattacharjee, JM. Biernacka, A. Birner, CS. Bloss, C. Brichant-Petitjean, ET. Bui, W. Byerley, P. Cervantes, C. Chillotti, S. Cichon, F. Colom, W. Coryell, DW. Craig, C. Cruceanu, PM. Czerski, T. Davis, A. Dayer, F. Degenhardt, M. Del Zompo, JR. DePaulo, HJ. Edenberg, B. Étain, P. Falkai, T. Foroud, AJ. Forstner, L. Frisén, MA. Frye, JM. Fullerton, S. Gard, JS. Garnham, ES. Gershon, FS. Goes, TA. Greenwood, M. Grigoroiu-Serbanescu, J. Hauser, U. Heilbronner, S. Heilmann-Heimbach, S. Herms, M. Hipolito, S. Hitturlingappa, P. Hoffmann, A. Hofmann, S. Jamain, E. Jiménez, JP. Kahn, L. Kassem, JR. Kelsoe, S. Kittel-Schneider, S. Kliwicki, DL. Koller, B. König, N. Lackner, G. Laje, M. Lang, C. Lavebratt, WB. Lawson, M. Leboyer, SG. Leckband, C. Liu, A. Maaser, PB. Mahon, W. Maier, M. Maj, M. Manchia, L. Martinsson, MJ. McCarthy, SL. McElroy, MG. McInnis, R. McKinney, PB. Mitchell, M. Mitjans, FM. Mondimore, P. Monteleone, TW. Mühleisen, CM. Nievergelt, MM. Nöthen, T. Novák, JI. Nurnberger, EA. Nwulia, U. Ösby, A. Pfennig, JB. Potash, P. Propping, A. Reif, E. Reininghaus, J. Rice, M. Rietschel, GA. Rouleau, JK. Rybakowski, M. Schalling, WA. Scheftner, PR. Schofield, NJ. Schork, TG. Schulze, J. Schumacher, BW. Schweizer, G. Severino, T. Shekhtman, PD. Shilling, C. Simhandl, CM. Slaney, EN. Smith, A. Squassina, T. Stamm, P. Stopkova, F. Streit, J. Strohmaier, S. Szelinger, SK. Tighe, A. Tortorella, G. Turecki, E. Vieta, J. Volkert, SH. Witt, A. Wright, PP. Zandi, P. Zhang, S. Zollner, FJ. McMahon,
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- 700 1_
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- 700 1_
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- $a Schork, Nicholas J $u Scripps Translational Science Institute, La Jolla, CA, USA.
- 700 1_
- $a Schulze, Thomas G $u Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA. Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA. Institute of Psychiatric Phenomics and Genomics, Ludwig-Maximilians-University Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany. Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Schumacher, Johannes $u Institute of Human Genetics, University of Bonn, Germany. Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
- 700 1_
- $a Schweizer, Barbara W $u Department of Psychiatry and Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD, USA.
- 700 1_
- $a Severino, Giovanni $u Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
- 700 1_
- $a Shekhtman, Tatyana $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a Shilling, Paul D $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a Simhandl, Christian $u Bipolar Center Wiener Neustadt, Wiener Neustadt, Austria and.
- 700 1_
- $a Slaney, Claire M $u Department of Psychiatry, Dalhousie University, Halifax, Canada.
- 700 1_
- $a Smith, Erin N $u Scripps Translational Science Institute, La Jolla, CA, USA.
- 700 1_
- $a Squassina, Alessio $u Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
- 700 1_
- $a Stamm, Thomas $u Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Campus Charité Mitte, Berlin, Germany.
- 700 1_
- $a Stopkova, Pavla $u National Institute of Mental Health, Klecany, Czech Republic.
- 700 1_
- $a Streit, Fabian $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Strohmaier, Jana $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Szelinger, Szabolcs $u The Translational Genomics Research Institute, Phoenix, AZ, USA.
- 700 1_
- $a Tighe, Sarah K $u Department of Psychiatry, Carver College of Medicine, University of Iowa School of Medicine, Iowa City, IA, USA.
- 700 1_
- $a Tortorella, Alfonso $u Department of Psychiatry, University of Naples SUN, Naples, Italy.
- 700 1_
- $a Turecki, Gustavo $u Douglas Mental Health University Institute, McGill University, Montreal, Canada.
- 700 1_
- $a Vieta, Eduard $u Bipolar Disorder Program, Institute of Neuroscience, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Catalonia, Spain.
- 700 1_
- $a Volkert, Julia $u Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
- 700 1_
- $a Witt, Stephanie H $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Wright, Adam $u School of Psychiatry, University of New South Wales, and Black Dog Institute, Sydney, Australia.
- 700 1_
- $a Zandi, Peter P $u Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
- 700 1_
- $a Zhang, Peng $u Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
- 700 1_
- $a Zollner, Sebastian $u Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA.
- 700 1_
- $a McMahon, Francis J $u Intramural Research Program, National Institute of Mental Health, National Institutes of Health,U.S. Department of Health & Human Services, Bethesda, MD, USA, mcmahonf@mail.nih.gov.
- 773 0_
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