• Je něco špatně v tomto záznamu ?

Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder

M. Zvěřová, J. Hroudová, Z. Fišar, H. Hansíková, L. Kališová, E. Kitzlerová, A. Lambertová, J. Raboch,

. 2019 ; 15 (-) : 233-240. [pub] 20190114

Jazyk angličtina Země Nový Zéland

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19013446

Grantová podpora
NV15-28616A MZ0 CEP - Centrální evidence projektů

Background: Mitochondrial dysfunctions are implicated in the pathophysiology of mood disorders. We measured and examined the following selected mitochondrial parameters: citrate synthase (CS) activity, electron transport system (ETS) complex (complexes I, II, and IV) activities, and mitochondrial respiration in blood platelets. Patients and methods: The analyses were performed for 24 patients suffering from a depressive episode of bipolar affective disorder (BD), compared to 68 patients with MDD and 104 healthy controls. BD and unipolar depression were clinically evaluated using well-established diagnostic scales and questionnaires. Results: The CS, complex II, and complex IV activities were decreased in the depressive episode of BD patients; complex I and complex I/CS ratio were significantly increased compared to healthy controls. We observed significantly decreased complex II and CS activities in patients suffering from MDD compared to controls. Decreased respiration after complex I inhibition and increased residual respiration were found in depressive BD patients compared to controls. Physiological respiration and capacity of the ETS were decreased, and respiration after complex I inhibition was increased in MDD patients, compared to controls. Increased complex I activity can be a compensatory mechanism for decreased CS and complex II and IV activities. Conclusion: We can conclude that complex I and its abnormal activity contribute to the defects in cellular energy metabolism during a depressive episode of BD. The observed parameters could be used in a panel of biomarkers that could selectively distinguish BD depression from MDD and can be easily examined from blood elements.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19013446
003      
CZ-PrNML
005      
20201022122321.0
007      
ta
008      
190405s2019 nz f 000 0|eng||
009      
AR
024    7_
$a 10.2147/NDT.S188964 $2 doi
035    __
$a (PubMed)30679909
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a nz
100    1_
$a Zvěřová, Martina $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic, hroudova.jana@gmail.com.
245    10
$a Disturbances of mitochondrial parameters to distinguish patients with depressive episode of bipolar disorder and major depressive disorder / $c M. Zvěřová, J. Hroudová, Z. Fišar, H. Hansíková, L. Kališová, E. Kitzlerová, A. Lambertová, J. Raboch,
520    9_
$a Background: Mitochondrial dysfunctions are implicated in the pathophysiology of mood disorders. We measured and examined the following selected mitochondrial parameters: citrate synthase (CS) activity, electron transport system (ETS) complex (complexes I, II, and IV) activities, and mitochondrial respiration in blood platelets. Patients and methods: The analyses were performed for 24 patients suffering from a depressive episode of bipolar affective disorder (BD), compared to 68 patients with MDD and 104 healthy controls. BD and unipolar depression were clinically evaluated using well-established diagnostic scales and questionnaires. Results: The CS, complex II, and complex IV activities were decreased in the depressive episode of BD patients; complex I and complex I/CS ratio were significantly increased compared to healthy controls. We observed significantly decreased complex II and CS activities in patients suffering from MDD compared to controls. Decreased respiration after complex I inhibition and increased residual respiration were found in depressive BD patients compared to controls. Physiological respiration and capacity of the ETS were decreased, and respiration after complex I inhibition was increased in MDD patients, compared to controls. Increased complex I activity can be a compensatory mechanism for decreased CS and complex II and IV activities. Conclusion: We can conclude that complex I and its abnormal activity contribute to the defects in cellular energy metabolism during a depressive episode of BD. The observed parameters could be used in a panel of biomarkers that could selectively distinguish BD depression from MDD and can be easily examined from blood elements.
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hroudová, Jana $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic, hroudova.jana@gmail.com. Institute of Pharmacology, First Faculty of Medicine, Charles University and General University Hospital in Prague, 128 00 Prague 2, Czech Republic, hroudova.jana@gmail.com.
700    1_
$a Fišar, Zdeněk $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic, hroudova.jana@gmail.com.
700    1_
$a Hansíková, Hana $u Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic.
700    1_
$a Kališová, Lucie $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic, hroudova.jana@gmail.com.
700    1_
$a Kitzlerová, Eva $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic, hroudova.jana@gmail.com.
700    1_
$a Lambertová, Alena $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic, hroudova.jana@gmail.com.
700    1_
$a Raboch, Jiří $u Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, 120 00 Prague 2, Czech Republic, hroudova.jana@gmail.com.
773    0_
$w MED00183034 $t Neuropsychiatric disease and treatment $x 1176-6328 $g Roč. 15, č. - (2019), s. 233-240
856    41
$u https://pubmed.ncbi.nlm.nih.gov/30679909 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20190405 $b ABA008
991    __
$a 20201022122318 $b ABA008
999    __
$a ind $b bmc $g 1392756 $s 1051751
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 15 $c - $d 233-240 $e 20190114 $i 1176-6328 $m Neuropsychiatric disease and treatment $n Neuropsychiatr Dis Treat $x MED00183034
GRA    __
$a NV15-28616A $p MZ0
LZP    __
$a Pubmed-20190405
Zpět

Najít záznam

Citační ukazatele

    Možnosti archivace