Hypokinetic dysarthria (HD) and freezing of gait (FOG) are both axial symptoms that occur in patients with Parkinson's disease (PD). It is assumed they have some common pathophysiological mechanisms and therefore that speech disorders in PD can predict FOG deficits within the horizon of some years. The aim of this study is to employ a complex quantitative analysis of the phonation, articulation and prosody in PD patients in order to identify the relationship between HD and FOG, and establish a mathematical model that would predict FOG deficits using acoustic analysis at baseline. We enrolled 75 PD patients who were assessed by 6 clinical scales including the Freezing of Gait Questionnaire (FOG-Q). We subsequently extracted 19 acoustic measures quantifying speech disorders in the fields of phonation, articulation and prosody. To identify the relationship between HD and FOG, we performed a partial correlation analysis. Finally, based on the selected acoustic measures, we trained regression models to predict the change in FOG during a 2-year follow-up. We identified significant correlations between FOG-Q scores and the acoustic measures based on formant frequencies (quantifying the movement of the tongue and jaw) and speech rate. Using the regression models, we were able to predict a change in particular FOG-Q scores with an error of between 7.4 and 17.0 %. This study is suggesting that FOG in patients with PD is mainly linked to improper articulation, a disturbed speech rate and to intelligibility. We have also proved that the acoustic analysis of HD at the baseline can be used as a predictor of the FOG deficit during 2 years of follow-up. This knowledge enables researchers to introduce new cognitive systems that predict gait difficulties in PD patients.

1st Department of Neurology St Anne's University Hospital Pekarska 53 656 91 Brno Czech Republic 3Applied Neuroscience Research Group Central European Institute of Technology Masaryk University Kamenice 5 62500 Brno Czech Republic

Applied Neuroscience Research Group Central European Institute of Technology Masaryk University Kamenice 5 62500 Brno Czech Republic

Applied Neuroscience Research Group Central European Institute of Technology Masaryk University Kamenice 5 62500 Brno Czech Republic 4Department of Neurology Faculty Hospital and Masaryk University Jihlavska 20 63900 Brno Czech Republic

Data and Signal Processing Research Group University of Vic Central University of Catalonia Perot Rocaguinarda 17 08500 Vic Catalonia Spain

Department of Telecommunications Brno University of Technology Technicka 10 61600 Brno Czech Republic

Escola Superior Politecnica Tecnocampus Avda Ernest Lluch 32 08302 Mataro Barcelona Spain

Neuromorphic Processing Laboratory Center for Biomedical Technology Universidad Politécnica de Madrid Campus de Montegancedo s n 28223 Pozuelo de Alarcón Madrid Spain

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