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Effect of Selected Stilbenoids on Human Fecal Microbiota

JD. Jaimes, V. Jarosova, O. Vesely, C. Mekadim, J. Mrazek, P. Marsik, J. Killer, K. Smejkal, P. Kloucek, J. Havlik,

. 2019 ; 24 (4) : . [pub] 20190219

Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19027795

Grant support
16-07193S Grantová Agentura České Republiky
CIGA 20172031 Česká Zemědělská Univerzita v Praze

Dietary phenolics or polyphenols are mostly metabolized by the human gut microbiota. These metabolites appear to confer the beneficial health effects attributed to phenolics. Microbial composition affects the type of metabolites produced. Reciprocally, phenolics modulate microbial composition. Understanding this relationship could be used to positively impact health by phenolic supplementation and thus create favorable colonic conditions. This study explored the effect of six stilbenoids (batatasin III, oxyresveratrol, piceatannol, pinostilbene, resveratrol, thunalbene) on the gut microbiota composition. Stilbenoids were anaerobically fermented with fecal bacteria from four donors, samples were collected at 0 and 24 h, and effects on the microbiota were assessed by 16S rRNA gene sequencing. Statistical tests identified affected microbes at three taxonomic levels. Observed microbial composition modulation by stilbenoids included a decrease in the Firmicutes to Bacteroidetes ratio, a decrease in the relative abundance of strains from the genus Clostridium, and effects on the family Lachnospiraceae. A frequently observed effect was a further decrease of the relative abundance when compared to the control. An opposite effect to the control was observed for Faecalibacterium prausnitzii, whose relative abundance increased. Observed effects were more frequently attributed to resveratrol and piceatannol, followed by thunalbene and batatasin III.

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$a Jaimes, Jose D $u Department of Food Quality and Safety, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic. jose.d.jaimes@gmail.com.
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$a Effect of Selected Stilbenoids on Human Fecal Microbiota / $c JD. Jaimes, V. Jarosova, O. Vesely, C. Mekadim, J. Mrazek, P. Marsik, J. Killer, K. Smejkal, P. Kloucek, J. Havlik,
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$a Dietary phenolics or polyphenols are mostly metabolized by the human gut microbiota. These metabolites appear to confer the beneficial health effects attributed to phenolics. Microbial composition affects the type of metabolites produced. Reciprocally, phenolics modulate microbial composition. Understanding this relationship could be used to positively impact health by phenolic supplementation and thus create favorable colonic conditions. This study explored the effect of six stilbenoids (batatasin III, oxyresveratrol, piceatannol, pinostilbene, resveratrol, thunalbene) on the gut microbiota composition. Stilbenoids were anaerobically fermented with fecal bacteria from four donors, samples were collected at 0 and 24 h, and effects on the microbiota were assessed by 16S rRNA gene sequencing. Statistical tests identified affected microbes at three taxonomic levels. Observed microbial composition modulation by stilbenoids included a decrease in the Firmicutes to Bacteroidetes ratio, a decrease in the relative abundance of strains from the genus Clostridium, and effects on the family Lachnospiraceae. A frequently observed effect was a further decrease of the relative abundance when compared to the control. An opposite effect to the control was observed for Faecalibacterium prausnitzii, whose relative abundance increased. Observed effects were more frequently attributed to resveratrol and piceatannol, followed by thunalbene and batatasin III.
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$a Jarosova, Veronika $u Department of Food Quality and Safety, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic. jarosovaverca@gmail.com. Department of Microbiology, Nutrition and Dietetics, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic. jarosovaverca@gmail.com.
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$a Veselý, Ondřej $u Department of Food Quality and Safety, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic. czeveselyo@gmail.com. $7 xx0257634
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$a Mekadim, Chahrazed $u Department of Microbiology, Nutrition and Dietetics, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic. Chahrazedbiotek@gmail.com. Institute of Animal Physiology and Genetics, CAS, v.v.i., Videnska 1083, 14220 Prague, Czech Republic. Chahrazedbiotek@gmail.com.
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$a Mrazek, Jakub $u Institute of Animal Physiology and Genetics, CAS, v.v.i., Videnska 1083, 14220 Prague, Czech Republic. kubino77@gmail.com.
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$a Marsik, Petr $u Department of Food Quality and Safety, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic. marsik@af.czu.cz.
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$a Killer, Jiri $u Institute of Animal Physiology and Genetics, CAS, v.v.i., Videnska 1083, 14220 Prague, Czech Republic. killer.jiri@seznam.cz.
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$a Smejkal, Karel $u Department of Natural Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences Brno, Palackeho 1946/1, 61242 Brno, Czech Republic. karel.mejkal@post.cz.
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$a Kloucek, Pavel $u Department of Food Quality and Safety, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic. kloucek@af.czu.cz.
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$a Havlik, Jaroslav $u Department of Food Quality and Safety, Czech University of Life Sciences Prague, Kamycka 129, 16500 Prague 6-Suchdol, Czech Republic. havlik@af.czu.cz.
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