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Human Wharton's jelly mesenchymal stem cells: properties, isolation and clinical applications

S. Borys-Wójcik, M. Brązert, M. Jankowski, K. Ożegowska, B. Chermuła, H. Piotrowska-Kempisty, D. Bukowska, P. Antosik, L. Pawelczyk, M. Nowicki, M. Jeseta, B. Kempisty,

. 2019 ; 33 (1) : 119-123. [pub] -

Jazyk angličtina Země Itálie

Typ dokumentu dopisy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19027845

Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.

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$a Human Wharton's jelly mesenchymal stem cells (WJ-MSCs) exhibit CD29, CD79 and CD105 markers, characteristic for mesenchymal cell lines. Under the influence of the appropriate factors, WJ-MSCs can be dedifferentiated to osteoblasts, chondrocytes, adipocytes, myocytes, cardiomyocytes, glial cells and dopaminergic neurons. Wharton's jelly (WJ) is one of the potential sources of mesenchymal stem cells (MSCs) - obtaining these cells does not raise moral or ethical objections, because the umbilical cord (UC) is a regular waste material. The expression of the OCT-4 and Nanog proteins, which are characteristic for WJ-MSCs may indicate that these cells have retained some embryonic character. The collected data suggests that WJMSCs show increased division and telomerase activity compared to bone marrow MSCs (BM-MSCs). The published results showed no human leucocyte antigen (HLA) class II expression, with the possibility of HLA class I modification by WJ-MSCs, allowing for the transplantation of these cells both within the same and other species - which allows the use of human cells in animal models. The results of selected studies indicate that WJ-MSCs can be an essential element of regenerative medicine of the 21st century.
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$a Brązert, M $u Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland.
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$a Jankowski, M $u Department of Anatomy, Poznan University of Medical Sciences, Poznan, Poland.
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$a Ożegowska, K $u Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland.
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$a Chermuła, B $u Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland.
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$a Piotrowska-Kempisty, H $u Department of Toxicology, Poznan University of Medical Sciences, Poznan, Poland.
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$a Bukowska, D $u Veterinary Center, Nicolaus Copernicus University in Torun, Torun, Poland.
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$a Antosik, P $u Veterinary Center, Nicolaus Copernicus University in Torun, Torun, Poland.
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$a Pawelczyk, L $u Division of Infertility and Reproductive Endocrinology, Department of Gynecology, Obstetrics and Gynecological Oncology, Poznan University of Medical Sciences, Poznan, Poland.
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$a Nowicki, M $u Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland.
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$a Jeseta, M $u Department of Obstetrics and Gynecology, University Hospital and Masaryk University, Brno, Czech Republic.
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$a Kempisty, B $u Department of Anatomy, Poznan University of Medical Sciences, Poznan, Poland. Department of Histology and Embryology, Poznan University of Medical Sciences, Poznan, Poland. Department of Obstetrics and Gynecology, University Hospital and Masaryk University, Brno, Czech Republic.
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