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Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations
WC. Chang, J. Kudlacek, J. Hlinka, J. Chvojka, M. Hadrava, V. Kumpost, AD. Powell, R. Janca, MI. Maturana, PJ. Karoly, DR. Freestone, MJ. Cook, M. Palus, J. Otahal, JGR. Jefferys, P. Jiruska,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
G0802162
Medical Research Council - United Kingdom
NV15-29835A
MZ0
CEP - Centrální evidence projektů
NV17-28427A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Plný text - Článek
Zdroj
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- elektroencefalografie MeSH
- hipokampální oblast CA1 patofyziologie MeSH
- hipokampus patofyziologie MeSH
- lidé MeSH
- nervová síť patofyziologie MeSH
- potkani Sprague-Dawley MeSH
- potkani Wistar MeSH
- synapse fyziologie MeSH
- záchvaty patofyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.
Citace poskytuje Crossref.org
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- $a Chang, Wei-Chih $u Neuronal Networks Group, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK. Faculty of Veterinary Medicine and Neuroscience Center, University of Helsinki, Helsinki, Finland.
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- $a Loss of neuronal network resilience precedes seizures and determines the ictogenic nature of interictal synaptic perturbations / $c WC. Chang, J. Kudlacek, J. Hlinka, J. Chvojka, M. Hadrava, V. Kumpost, AD. Powell, R. Janca, MI. Maturana, PJ. Karoly, DR. Freestone, MJ. Cook, M. Palus, J. Otahal, JGR. Jefferys, P. Jiruska,
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- $a The mechanism of seizure emergence and the role of brief interictal epileptiform discharges (IEDs) in seizure generation are two of the most important unresolved issues in modern epilepsy research. We found that the transition to seizure is not a sudden phenomenon, but is instead a slow process that is characterized by the progressive loss of neuronal network resilience. From a dynamical perspective, the slow transition is governed by the principles of critical slowing, a robust natural phenomenon that is observable in systems characterized by transitions between dynamical regimes. In epilepsy, this process is modulated by synchronous synaptic input from IEDs. IEDs are external perturbations that produce phasic changes in the slow transition process and exert opposing effects on the dynamics of a seizure-generating network, causing either anti-seizure or pro-seizure effects. We found that the multifaceted nature of IEDs is defined by the dynamical state of the network at the moment of the discharge occurrence.
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- $a Kudlacek, Jan $u Department of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic.
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- $a Maturana, Matias I $u The Graeme Clark Institute & Department of Medicine St. Vincent's Hospital, The University of Melbourne, Melbourne, Australia.
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- $a Jiruska, Premysl $u Department of Developmental Epileptology, Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic. jiruskapremysl@gmail.com.
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