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A catalog of genetic loci associated with kidney function from analyses of a million individuals

M. Wuttke, Y. Li, M. Li, KB. Sieber, MF. Feitosa, M. Gorski, A. Tin, L. Wang, AY. Chu, A. Hoppmann, H. Kirsten, A. Giri, JF. Chai, G. Sveinbjornsson, BO. Tayo, T. Nutile, C. Fuchsberger, J. Marten, M. Cocca, S. Ghasemi, Y. Xu, K. Horn, D. Noce,...

. 2019 ; 51 (6) : 957-972. [pub] 20190531

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, metaanalýza, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19034530

Grantová podpora
Z01 AG000513-08 Intramural NIH HHS - United States
Z99 AG999999 Intramural NIH HHS - United States

E-zdroje Online Plný text

NLK ProQuest Central od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest) od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest) od 2000-01-01 do Před 1 rokem

Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.

Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing Tongren Hospital Capital Medical University Beijing China

Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing China

Biochemistry Wake Forest School of Medicine Winston Salem NC USA

Cardiology Department of Medical Sciences Uppsala University Uppsala Sweden Uppsala Clinical Research Center Uppsala University Uppsala Sweden

Cardiology Geneva University Hospitals Geneva Switzerland

Cardiovascular Division Brigham and Women's Hospital Boston MA USA TIMI Study Group Boston MA USA

Cardiovascular Epidemiology Department of Medical Sciences Uppsala University Uppsala Sweden

Cardiovascular Health Research Unit Department of Medicine Department of Epidemiology Department of Health Service University of Washington Seattle WA USA Kaiser Permanente Washington Health Research Institute Seattle WA USA

Cardiovascular Health Research Unit Department of Medicine University of Washington Seattle WA USA Department of Biostatistics University of Washington Seattle WA USA

Center for Cardiovascular Prevention Charles University Prague 1st Faculty of Medicine and Thomayer Hospital Prague Czech Republic Department of Medicine 2 Charles University Prague 1st Faculty of Medicine Prague Czech Republic

Center for Genomic and Experimental Medicine Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh UK

Center for Genomic and Experimental Medicine Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh UK Center for Cognitive Ageing and Cognitive Epidemiology University of Edinburgh Edinburgh UK

Center for Global Health Research Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh UK

Center for Population Health Sciences Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh UK

Center for Public Health Genomics University of Virginia Charlottesville Charlottesville VA USA

Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA

Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA Digital Health Center Hasso Plattner Institute and University of Potsdam Potsdam Germany

Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA Division of Nephrology Department of Medicine Icahn School of Medicine at Mount Sinai New York NY USA

Charles Bronfman Institute for Personalized Medicine Icahn School of Medicine at Mount Sinai New York NY USA The Mindich Child Health and Development Institute Icahn School of Medicine at Mount Sinai New York NY USA

Clinical Division of Neurogeriatrics Department of Neurology Medical University of Graz Graz Austria

Clinical Division of Neurogeriatrics Department of Neurology Medical University of Graz Graz Austria Institute for Medical Informatics Statistics and Documentation Medical University of Graz Graz Austria

CNRS UMR 8199 European Genomic Institute for Diabetes Institut Pasteur de Lille University of Lille Lille France

CNRS UMR 8199 European Genomic Institute for Diabetes Institut Pasteur de Lille University of Lille Lille France Department of Genomics of Common Disease Imperial College London London UK

Department of Biomedical Informatics Vanderbilt University Medical Center Nashville TN USA

Department of Biostatistics and Center for Statistical Genetics University of Michigan Ann Arbor MI USA

Department of Biostatistics Boston University School of Public Health Boston MA USA

Department of Biostatistics University of Liverpool Liverpool UK

Department of Biostatistics University of Liverpool Liverpool UK Wellcome Trust Center for Human Genetics University of Oxford Oxford UK

Department of Biostatistics University of Washington Seattle WA USA

Department of Cardiology Ealing Hospital Middlesex UK Department of Epidemiology and Biostatistics MRC PHE Center for Environment and Health School of Public Health Imperial College London London UK

Department of Cardiology Ealing Hospital Middlesex UK Imperial College Healthcare NHS Trust Imperial College London London UK MRC PHE Center for Environment and Health School of Public Health Imperial College London London UK National Heart and Lung Institute Imperial College London London UK

Department of Cardiology Heart Center Tampere University Hospital Tampere Finland Department of Cardiology Finnish Cardiovascular Research Center Tampere Faculty of Medicine and Life Sciences Tampere University Tampere Finland

Department of Cardiology University of Groningen University Medical Center Groningen Groningen the Netherlands

Department of Cardiology University of Groningen University Medical Center Groningen Groningen the Netherlands Department of Genetics University of Groningen University Medical Center Groningen Groningen the Netherlands Durrer Center for Cardiovascular Research The Netherlands Heart Institute Utrecht the Netherlands

Department of Clinical Biochemistry Landspitali University Hospital Reykjavik Iceland

Department of Clinical Chemistry Fimlab Laboratories Tampere Finland Department of Clinical Chemistry Finnish Cardiovascular Research Center Tampere Faculty of Medicine and Life Sciences University of Tampere Tampere Finland

Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands

Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands Department of Public Health and Primary Care Leiden University Medical Center Leiden the Netherlands

Department of Clinical Physiology and Nuclear Medicine Turku University Hospital Turku Finland Research Center of Applied and Preventive Cardiovascular Medicine University of Turku Turku Finland

Department of Clinical Physiology Tampere University Hospital Tampere Finland Department of Clinical Physiology Finnish Cardiovascular Research Center Tampere Faculty of Medicine and Health Technology Tampere University Tampere Finland

Department of Clinical Science and Education Karolinska Institutet Södersjukhuset Stockholm Sweden Department of Cardiology Södersjukhuset Stockholm Sweden

Department of Computational Biology University of Lausanne Lausanne Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland

Department of Computational Biology University of Lausanne Lausanne Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland Department of Integrative Biomedical Sciences University of Cape Town Cape Town South Africa

Department of Computational Biology University of Lausanne Lausanne Switzerland Swiss Institute of Bioinformatics Lausanne Switzerland Institute of Social and Preventive Medicine Lausanne University Hospital Lausanne Switzerland

Department of Endocrinology and Nephrology University of Leipzig Leipzig Germany

Department of Epidemiology and Biostatistics Faculty of Medicine School of Public Health Imperial College London London UK

Department of Epidemiology and Biostatistics Faculty of Medicine School of Public Health Imperial College London London UK Department of Epidemiology and Biostatistics MRC PHE Center for Environment and Health School of Public Health Imperial College London London UK

Department of Epidemiology and Biostatistics Faculty of Medicine School of Public Health Imperial College London London UK Institute of Public Health and Social Sciences Khyber Medical University Peshawar Pakistan

Department of Epidemiology and Biostatistics Faculty of Medicine School of Public Health Imperial College London London UK Lee Kong Chian School of Medicine Nanyang Technological University Singapore Singapore Department of Cardiology Ealing Hospital Middlesex UK Imperial College Healthcare NHS Trust Imperial College London London UK MRC PHE Center for Environment and Health School of Public Health Imperial College London London UK

Department of Epidemiology and Biostatistics MRC PHE Center for Environment and Health School of Public Health Imperial College London London UK

Department of Epidemiology and Biostatistics MRC PHE Center for Environment and Health School of Public Health Imperial College London London UK Department of Hygiene and Epidemiology University of Ioannina Medical School Ioannina Greece

Department of Epidemiology and Biostatistics MRC PHE Center for Environment and Health School of Public Health Imperial College London London UK Imperial College NIHR Biomedical Research Center Imperial College London London UK Dementia Research Institute Imperial College London London UK Health Data Research UK London London UK

Department of Epidemiology Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands

Department of Epidemiology Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands Department of Internal Medicine Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands

Department of Epidemiology Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands Generation R Study Group Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands Department of Pediatrics Erasmus MC University Medical Center Rotterdam Rotterdam The Netherlands

Department of Epidemiology Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands Institute of Social and Preventive Medicine University of Bern Bern Switzerland

Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA

Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA Department of Biostatistics Johns Hopkins Bloomberg School of Public Health Baltimore MD USA

Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA Welch Center for Prevention Epidemiology and Clinical Research Baltimore MD USA

Department of Epidemiology University of Groningen University Medical Center Groningen Groningen the Netherlands

Department of Genetic Epidemiology University of Regensburg Regensburg Germany

Department of Genetics Shanghai MOST Key Laboratory of Health and Disease Genomics Chinese National Human Genome Center Shanghai China Shanghai Industrial Technology Institute Shanghai China

Department of Genetics University of North Carolina Chapel Hill NC USA

Department of Health Sciences University of Milan Milano Italy ePhood Scientific Unit ePhood SRL Milano Italy

Department of Health Sciences University of Milan Milano Italy Neuroalgology Unit Fondazione IRCCS Istituto Neurologico 'Carlo Besta' Milan Italy

Department of Human Genetics Graduate School of Public Health University of Pittsburgh Pittsburgh PA USA

Department of Internal Medicine Erasmus MC University Medical Center Rotterdam Rotterdam the Netherlands

Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden

Department of Medicine Geriatrics Section Boston Medical Center Boston University School of Medicine Boston MA USA

Department of Medicine Kuopio University Hospital Kuopio Finland

Department of Medicine Kuopio University Hospital Kuopio Finland Institute of Clinical Medicine Internal Medicine University of Eastern Finland Kuopio Finland

Department of Medicine Medical Faculty Mannheim University of Heidelberg Mannheim Germany

Department of Medicine Surgery and Health Sciences University of Trieste Trieste Italy

Department of Nephrology University Hospital Regensburg Regensburg Germany

Department of Nephrology University Hospital Regensburg Regensburg Germany Department of Genetic Epidemiology University of Regensburg Regensburg Germany

Department of Nephrology University Hospital Regensburg Regensburg Germany Department of Nephrology and Rheumatology Kliniken Südostbayern Regensburg Germany

Department of Neurology College of Physicians and Surgeons Columbia University New York NY USA Gertrude H Sergievsky Center Columbia University Medical Center New York NY USA Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University Medical Center New York USA

Department of Ophthalmology Medical Faculty Mannheim University Heidelberg Mannheim Germany Beijing Institute of Ophthalmology Beijing Key Laboratory of Ophthalmology and Visual Sciences Beijing Tongren Hospital Capital Medical University Beijing China

Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore

Department of Paediatrics Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore Khoo Teck Puat National University Children's Medical Institute National University Health System Singapore Singapore

Department of Pediatrics Tampere University Hospital Tampere Finland Department of Pediatrics Faculty of Medicine and Life Sciences University of Tampere Tampere Finland

Department of Physiology and Biophysics University of Mississippi Medical Center Jackson MS USA

Department of Psychiatry University Hospital of Lausanne Lausanne Switzerland

Department of Psychiatry VU University Medical Center Amsterdam the Netherlands

Department of Public Health and Primary Care School of Clinical Medicine University of Cambridge Cambridge UK

Department of Public Health and Primary Care University of Cambridge Cambridge UK NHS Blood and Transplant Cambridge UK

Department of Public Health Sciences Loyola University Chicago Maywood IL USA

Department of Public Health Sciences Loyola University Chicago Maywood IL USA Division of Nephrology and Hypertension Loyola University Chicago Chicago IL USA

Department of Translational Research in Psychiatry Max Planck Institute of Psychiatry Munich Germany

Department of Veteran's Affairs Tennessee Valley Healthcare System Vanderbilt University Nashville TN USA Department of Obstetrics and Gynecology Institute for Medicine and Public Health Vanderbilt University Medical Center Nashville TN USA

Department of Veteran's Affairs Tennessee Valley Healthcare System Vanderbilt University Nashville TN USA Division of Epidemiology Department of Medicine Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville TN USA

Department of Veteran's Affairs Tennessee Valley Healthcare System Vanderbilt University Nashville TN USA Vanderbilt University Medical Center Division of Nephrology and Hypertension Nashville TN USA

Department of Women and Child Health Hospital for Children and Adolescents University of Leipzig Leipzig Germany Center for Pediatric Research University of Leipzig Leipzig Germany

Deutsches Herzzentrum München Technische Universität München Munich Germany DZHK Partner Site Munich Heart Alliance Munich Germany Institute of Epidemiology and Biostatistics University of Ulm Ulm Germany

Diabetes and Cardiovascular Disease Genetic Epidemiology Department of Clincial Sciences in Malmö Lund University Malmö Sweden

Division of Biomedical Informatics and Personalized Medicine School of Medicine University of Colorado Denver Anschutz Medical Campus Aurora CO USA

Division of Cardiovascular Medicine Department of Medicine Stanford University School of Medicine Stanford CA USA Stanford Cardiovascular Institute Stanford University Stanford CA USA Molecular Epidemiology and Science for Life Laboratory Department of Medical Sciences Uppsala University Uppsala Sweden Stanford Diabetes Research Center Stanford University Stanford CA USA

Division of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg Germany

Division of Clinical Epidemiology and Aging Research German Cancer Research Center Heidelberg Germany Network Aging Research University of Heidelberg Heidelberg Germany

Division of Endocrinology Diabetes and Nutrition University of Maryland School of Medicine Baltimore MD USA

Division of Family Medicine and Primary Care Department of Neurobiology Care Sciences and Society Karolinska Institutet Stockholm Sweden School of Health and Social Studies Dalarna University Stockholm Sweden

Division of Genetic Epidemiology Department of Medical Genetics Molecular and Clinical Pharmacology Medical University of Innsbruck Innsbruck Austria

Division of Kidney Urologic and Hematologic Diseases National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD USA Department of Medicine University of Maryland School of Medicine Baltimore MD USA

Division of Molecular Genetic Epidemiology German Cancer Research Center Heidelberg Germany

Division of Nephrology and Hypertension Department of Medicine University of Utah Salt Lake City USA

Division of Nephrology Department of Internal Medicine University of Groningen University Medical Center Groningen Groningen the Netherlands

Division of Nephrology Internal Medicine Services Landspitali The National University Hospital of Iceland Reykjavik Iceland

Division of Nephrology University of Washington Seattle WA USA Kidney Research Institute University of Washington Seattle WA USA

Division of Population Health and Genomics Ninewells Hospital and Medical School University of Dundee Dundee UK

Division of Preventive Medicine Brigham and Women's Hospital Boston MA USA

Division of Preventive Medicine Brigham and Women's Hospital Boston MA USA Harvard Medical School Boston MA USA

Division of Quantitative Sciences Department of Obstetrics and Gynecology Vanderbilt Genetics Institute Vanderbilt Epidemiology Center Institute for Medicine and Public Health Vanderbilt University Medical Center Nashville TN USA Biomedical Laboratory Research and Development Tennessee Valley Healthcare System Vanderbilt University Nashville TN USA

Division of Statistical Genomics Department of Genetics Washington University School of Medicine St Louis MO USA

DZHK partner site Greifswald Greifswald Germany Department of Anatomy and Cell Biology University Medicine Greifswald Greifswald Germany

DZHK partner site Greifswald Greifswald Germany Institute of Clinical Chemistry and Laboratory Medicine University Medicine Greifswald Greifswald Germany

DZHK partner site Greifswald Greifswald Germany Interfaculty Institute for Genetics and Functional Genomics University Medicine Greifswald Greifswald Germany

DZHK Partner Site Munich Heart Alliance Munich Germany Institute of Human Genetics Helmholtz Zentrum München Neuherberg Germany Institute of Human Genetics Technische Universität München Munich Germany

eCODE Genetics Amgen Inc Reykjavik Iceland

Estonian Genome Center Institute of Genomics University of Tartu Tartu Estonia

Eurac Research Institute for Biomedicine Bolzano Italy

Faculty of Medicine School of Health Sciences University of Iceland Reykjavik Iceland

Faculty of Medicine School of Health Sciences University of Iceland Reykjavik Iceland Division of Nephrology Internal Medicine Services Landspitali The National University Hospital of Iceland Reykjavik Iceland

Faculty of Medicine University of Split Split Croatia Gen info Ltd Zagreb Croatia

Geisinger Research Biomedical and Translational Informatics Institute Danville PA USA

Geisinger Research Biomedical and Translational Informatics Institute Rockville MD USA

Genetics Merck and Co Inc Kenilworth NJ USA

Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore

Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore

Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China

Green Lane Cardiovascular Service Auckland City Hospital and University of Auckland Auckland New Zealand

Human Genetics Center University of Texas Health Science Center Houston TX USA

Human Genetics Wellcome Sanger Institute Hinxton UK

Hypertension and Cardiovascular Disease Department of Clincial Sciences Malmö Lund University Malmö Sweden

Icelandic Heart Association Kopavogur Iceland Faculty of Medicine School of Health Sciences University of Iceland Reykjavik Iceland

Independent Research Group Clinical Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany Chair of Epidemiology Ludwig Maximilians Universität München at UNIKA T Augsburg Augsburg Germany

Institute for Community Medicine University Medicine Greifswald Greifswald Germany DZHK partner site Greifswald Greifswald Germany

Institute for Maternal and Child Health IRCCS 'Burlo Garofolo' Trieste Italy

Institute for Maternal and Child Health IRCCS 'Burlo Garofolo' Trieste Italy Department of Medicine Surgery and Health Sciences University of Trieste Trieste Italy

Institute for Medical Informatics Statistics and Epidemiology University of Leipzig Leipzig Germany LIFE Research Center for Civilization Diseases University of Leipzig Leipzig Germany

Institute for Molecular Bioscience University of Queensland St Lucia Queensland Australia

Institute of Biomedical Technologies National Research Council of Italy Milan Italy Bio4Dreams Business Nursery for Life Sciences Milan Italy

Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK

Institute of Clinical Molecular Biology Christian Albrechts University of Kiel Kiel Germany

Institute of Epidemiology and Biobank Popgen Kiel University Kiel Germany

Institute of Genetic and Biomedical Research National Research Council of Italy UOS of Sassari Li Punti Sassari Italy

Institute of Genetic Epidemiology Department of Biometry Epidemiology and Medical Bioinformatics Faculty of Medicine and Medical Center University of Freiburg Freiburg Germany

Institute of Genetic Epidemiology Department of Biometry Epidemiology and Medical Bioinformatics Faculty of Medicine and Medical Center University of Freiburg Freiburg Germany Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA

Institute of Genetic Epidemiology Department of Biometry Epidemiology and Medical Bioinformatics Faculty of Medicine and Medical Center University of Freiburg Freiburg Germany Renal Division Department of Medicine 4 Faculty of Medicine and Medical Center University of Freiburg Freiburg Germany

Institute of Genetic Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany Chair of Genetic Epidemiology IBE Faculty of Medicine Ludwig Maximilians Universität München München Germany

Institute of Genetics and Biophysics 'Adriano Buzzati Traverso' CNR Naples Italy

Institute of Genetics and Biophysics 'Adriano Buzzati Traverso' CNR Naples Italy IRCCS Neuromed Pozzilli Italy

Institute of Medical Informatics and Statistics Kiel University University Hospital Schleswig Holstein Kiel Germany

Institute of Molecular Biology and Biochemistry Center for Molecular Medicine Medical University of Graz Graz Austria

Institute of Molecular Genetics National Research Council of Italy Pavia Italy

Institute of Physiology University Medicine Greifswald Karlsburg Germany

Institute of Physiology University of Zurich Zurich Switzerland

Institute of Social and Preventive Medicine Lausanne University Hospital Lausanne Switzerland

Integrated Research and Treatment Center Adiposity Diseases University of Leipzig Leipzig Germany

Intensive Care Medicine Charité Berlin Germany Department of Nephrology and Hypertension Friedrich Alexander University Erlangen Nürnberg Erlangen Germany

Interdisciplinary Center of Psychopathology and Emotion Regulation University of Groningen University Medical Center Groningen Groningen the Netherlands

Internal Medicine Department of Medicine Lausanne University Hospital Lausanne Switzerland

Kidney Health Research Institute Geisinger Danville PA USA Department of Nephrology Geisinger Danville PA USA

Kidney Research Institute University of Washington Seattle WA USA Anatomic Pathology University of Washington Medical Center Seattle WA USA

Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Osaka Japan Department of Statistical Genetics Osaka University Graduate School of Medicine Osaka Japan

Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan Department of Biomedical Informatics Harvard Medical School Boston MA USA

Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan Department of Ophthalmology Graduate School of Medical Sciences Kyushu University Fukuoka Japan

Laboratory for Statistical Analysis RIKEN Center for Integrative Medical Sciences Yokohama Japan Kyoto McGill International Collaborative School in Genomic Medicine Kyoto University Graduate School of Medicine Kyoto Japan

Laboratory of Clinical Genome Sequencing Graduate School of Frontier Sciences The University of Tokyo Tokyo Japan

Laboratory of Epidemiology and Population Sciences National Institute on Aging Intramural Research Program US National Institutes of Health Baltimore MD USA

Laboratory of Epidemiology and Population Sciences National Institute on Aging Intramural Research Program US National Institutes of Health Bethesda MD USA

Laboratory of Neurogenetics National Institute on Aging National Institutes of Health Bethesda MD USA Data Tecnica International Glen Echo MD USA

LIFE Research Center for Civilization Diseases University of Leipzig Leipzig Germany

LIFE Research Center for Civilization Diseases University of Leipzig Leipzig Germany Department of Women and Child Health Hospital for Children and Adolescents University of Leipzig Leipzig Germany Center for Pediatric Research University of Leipzig Leipzig Germany

LIFE Research Center for Civilization Diseases University of Leipzig Leipzig Germany Heart Center Leipzig Leipzig Germany

LIFE Research Center for Civilization Diseases University of Leipzig Leipzig Germany Institute of Laboratory Medicine Clinical Chemistry and Molecular Diagnostics University of Leipzig Leipzig Germany

LIFE Research Center for Civilization Diseases University of Leipzig Leipzig Germany Institute of Laboratory Medicine Clinical Chemistry and Molecular Diagnostics University of Leipzig Leipzig Germany Institute of Clinical Chemistry and Laboratory Medicine University Hospital Regensburg Regensburg Germany

Massachusetts Veterans Epidemiology Research and Information Center VA Cooperative Studies Program VA Boston Healthcare System Boston MA USA

Max Planck Institute of Psychiatry Munich Germany

Medical Research Council Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh UK

Medical Research Council Human Genetics Unit Institute of Genetics and Molecular Medicine University of Edinburgh Edinburgh UK Center for Global Health Research Usher Institute of Population Health Sciences and Informatics University of Edinburgh Edinburgh UK

Molecular Biology and Biochemistry Gottfried Schatz Research Center for Cell Signaling Metabolism and Aging Medical University of Graz Graz Austria

Molecular Geriatrics Department of Public Health and Caring Sciences Uppsala University Uppsala Sweden

Montreal University Hospital Research Center CHUM Montreal Quebec Canada CRCHUM Montreal Canada

Montreal University Hospital Research Center CHUM Montreal Quebec Canada Medpharmgene Montreal Quebec Canada

MRC BHF Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK

MRC BHF Cardiovascular Epidemiology Unit Department of Public Health and Primary Care University of Cambridge Cambridge UK National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics University of Cambridge Cambridge UK

National Institute for Health and Welfare Helsinki Finland

NHLBI's Framingham Heart Study Framingham MA USA The Center for Population Studies NHLBI Framingham MA USA

NHS Blood and Transplant BRC Oxford Haematology Theme

Nuffield Department of Medicine University of Oxford Oxford UK Broad Institute of Harvard and MIT Cambridge MA USA

Nuffield Division of Clinical Laboratory Sciences

Public Health Sciences Biostatistics Wake Forest School of Medicine Winston Salem NC USA

QIMR Berghofer Medical Research Institute Brisbane Queensland Australia

Research Unit of Molecular Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany

Research Unit of Molecular Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany Institute of Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany DZHK Partner Site Munich Heart Alliance Munich Germany

Research Unit of Molecular Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany Institute of Epidemiology Helmholtz Zentrum München German Research Center for Environmental Health Neuherberg Germany German Center for Diabetes Research Neuherberg Germany

RIKEN Center for Integrative Medical Sciences Japan

San Raffaele Research Institute Milan Italy

Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore

Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore

Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore Department of Medicine Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore Duke NUS Medical School Singapore Singapore

Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore Diabetes Center Khoo Teck Puat Hospital Singapore Singapore

School of Public Health and Community Medicine Hebrew University of Jerusalem Jerusalem Israel

Section of Gerontology and Geriatrics Department of Internal Medicine Leiden University Medical Center Leiden the Netherlands

Section of Nephrology Department of Internal Medicine Leiden University Medical Center Leiden the Netherlands

Section of Nephrology Department of Internal Medicine Leiden University Medical Center Leiden the Netherlands Einthoven Laboratory of Experimental Vascular Research Leiden University Medical Center Leiden the Netherlands

Section on Nephrology Internal Medicine Wake Forest School of Medicine Winston Salem NC USA

Service de Néphrologie Geneva University Hospitals Geneva Switzerland

Singapore Eye Research Institute Singapore National Eye Center Singapore Singapore

Singapore Eye Research Institute Singapore National Eye Center Singapore Singapore Department of Ophthalmology Tohoku University Graduate School of Medicine Miyagi Japan

Singapore Eye Research Institute Singapore National Eye Center Singapore Singapore Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore

Singapore Eye Research Institute Singapore National Eye Center Singapore Singapore Genome Institute of Singapore Agency for Science Technology and Research Singapore Singapore

Singapore Eye Research Institute Singapore National Eye Center Singapore Singapore Ophthalmology and Visual Sciences Academic Clinical Program Duke NUS Medical School Singapore Singapore Department of Ophthalmology Yong Loo Lin School of Medicine National University of Singapore and National University Health System Singapore Singapore

Steno Diabetes Center Copenhagen Gentofte Denmark

Synlab Academy Synlab Holding Deutschland GmbH Mannheim Germany Clinical Institute of Medical and Chemical Laboratory Diagnostics Medical University of Graz Graz Austria Medical Clinic 5 Medical Faculty Mannheim University of Heidelberg Mannheim Germany

Target Sciences Genetics GlaxoSmithKline Albuquerque NM USA

Target Sciences Genetics GlaxoSmithKline Collegeville PA USA

The Center of Public Health Sciences University of Iceland Reykjavík Iceland

The Department of Public Health Solutions National Institute for Health and Welfare Helsinki Finland Diabetes and Obesity Research Program University of Helsinki Helsinki Finland

The Institute for Translational Genomics and Population Sciences Department of Pediatrics Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center Torrance CA USA

The Institute for Translational Genomics and Population Sciences Department of Pediatrics Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center Torrance CA USA Department of Pediatrics Harbor UCLA Medical Center Torrance CA USA Department of Medicine Harbor UCLA Medical Center Torrance CA USA

Unit of Epidemiology Biostatistics and Biodemography Department of Public Health Southern Denmark University Odense Denmark

University of Maryland School of Medicine Baltimore MD USA

University of Oxford Oxford UK

Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville TN USA Division of Epidemiology Department of Medicine Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville TN USA Department of Veteran's Affairs Tennessee Valley Healthcare System Vanderbilt University Nashville TN USA

Wellcome Trust Center for Human Genetics University of Oxford Oxford UK Oxford Center for Diabetes Endocrinology and Metabolism University of Oxford Oxford UK

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$a Wuttke, Matthias $u Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. Renal Division, Department of Medicine IV, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
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$a A catalog of genetic loci associated with kidney function from analyses of a million individuals / $c M. Wuttke, Y. Li, M. Li, KB. Sieber, MF. Feitosa, M. Gorski, A. Tin, L. Wang, AY. Chu, A. Hoppmann, H. Kirsten, A. Giri, JF. Chai, G. Sveinbjornsson, BO. Tayo, T. Nutile, C. Fuchsberger, J. Marten, M. Cocca, S. Ghasemi, Y. Xu, K. Horn, D. Noce, PJ. van der Most, S. Sedaghat, Z. Yu, M. Akiyama, S. Afaq, TS. Ahluwalia, P. Almgren, N. Amin, J. Ärnlöv, SJL. Bakker, N. Bansal, D. Baptista, S. Bergmann, ML. Biggs, G. Biino, M. Boehnke, E. Boerwinkle, M. Boissel, EP. Bottinger, TS. Boutin, H. Brenner, M. Brumat, R. Burkhardt, AS. Butterworth, E. Campana, A. Campbell, H. Campbell, M. Canouil, RJ. Carroll, E. Catamo, JC. Chambers, ML. Chee, ML. Chee, X. Chen, CY. Cheng, Y. Cheng, K. Christensen, R. Cifkova, M. Ciullo, MP. Concas, JP. Cook, J. Coresh, T. Corre, CF. Sala, D. Cusi, J. Danesh, EW. Daw, MH. de Borst, A. De Grandi, R. de Mutsert, APJ. de Vries, F. Degenhardt, G. Delgado, A. Demirkan, E. Di Angelantonio, K. Dittrich, J. Divers, R. Dorajoo, KU. Eckardt, G. Ehret, P. Elliott, K. Endlich, MK. Evans, JF. Felix, VHX. Foo, OH. Franco, A. Franke, BI. Freedman, S. Freitag-Wolf, Y. Friedlander, P. Froguel, RT. Gansevoort, H. Gao, P. Gasparini, JM. Gaziano, V. Giedraitis, C. Gieger, G. Girotto, F. Giulianini, M. Gögele, SD. Gordon, DF. Gudbjartsson, V. Gudnason, T. Haller, P. Hamet, TB. Harris, CA. Hartman, C. Hayward, JN. Hellwege, CK. Heng, AA. Hicks, E. Hofer, W. Huang, N. Hutri-Kähönen, SJ. Hwang, MA. Ikram, OS. Indridason, E. Ingelsson, M. Ising, VWV. Jaddoe, J. Jakobsdottir, JB. Jonas, PK. Joshi, NS. Josyula, B. Jung, M. Kähönen, Y. Kamatani, CM. Kammerer, M. Kanai, M. Kastarinen, SM. Kerr, CC. Khor, W. Kiess, ME. Kleber, W. Koenig, JS. Kooner, A. Körner, P. Kovacs, AT. Kraja, A. Krajcoviechova, H. Kramer, BK. Krämer, F. Kronenberg, M. Kubo, B. Kühnel, M. Kuokkanen, J. Kuusisto, M. La Bianca, M. Laakso, LA. Lange, CD. Langefeld, JJ. Lee, B. Lehne, T. Lehtimäki, W. Lieb, Lifelines Cohort Study, SC. Lim, L. Lind, CM. Lindgren, J. Liu, J. Liu, M. Loeffler, RJF. Loos, S. Lucae, MA. Lukas, LP. Lyytikäinen, R. Mägi, PKE. Magnusson, A. Mahajan, NG. Martin, J. Martins, W. März, D. Mascalzoni, K. Matsuda, C. Meisinger, T. Meitinger, O. Melander, A. Metspalu, EK. Mikaelsdottir, Y. Milaneschi, K. Miliku, PP. Mishra, V. A. Million Veteran Program, KL. Mohlke, N. Mononen, GW. Montgomery, DO. Mook-Kanamori, JC. Mychaleckyj, GN. Nadkarni, MA. Nalls, M. Nauck, K. Nikus, B. Ning, IM. Nolte, R. Noordam, J. O'Connell, ML. O'Donoghue, I. Olafsson, AJ. Oldehinkel, M. Orho-Melander, WH. Ouwehand, S. Padmanabhan, ND. Palmer, R. Palsson, BWJH. Penninx, T. Perls, M. Perola, M. Pirastu, N. Pirastu, G. Pistis, AI. Podgornaia, O. Polasek, B. Ponte, DJ. Porteous, T. Poulain, PP. Pramstaller, MH. Preuss, BP. Prins, MA. Province, TJ. Rabelink, LM. Raffield, OT. Raitakari, DF. Reilly, R. Rettig, M. Rheinberger, KM. Rice, PM. Ridker, F. Rivadeneira, F. Rizzi, DJ. Roberts, A. Robino, P. Rossing, I. Rudan, R. Rueedi, D. Ruggiero, KA. Ryan, Y. Saba, C. Sabanayagam, V. Salomaa, E. Salvi, KU. Saum, H. Schmidt, R. Schmidt, B. Schöttker, CA. Schulz, N. Schupf, CM. Shaffer, Y. Shi, AV. Smith, BH. Smith, N. Soranzo, CN. Spracklen, K. Strauch, HM. Stringham, M. Stumvoll, PO. Svensson, S. Szymczak, ES. Tai, SM. Tajuddin, NYQ. Tan, KD. Taylor, A. Teren, YC. Tham, J. Thiery, CHL. Thio, H. Thomsen, G. Thorleifsson, D. Toniolo, A. Tönjes, J. Tremblay, I. Tzoulaki, AG. Uitterlinden, S. Vaccargiu, RM. van Dam, P. van der Harst, CM. van Duijn, DR. Velez Edward, N. Verweij, S. Vogelezang, U. Völker, P. Vollenweider, G. Waeber, M. Waldenberger, L. Wallentin, YX. Wang, C. Wang, DM. Waterworth, W. Bin Wei, H. White, JB. Whitfield, SH. Wild, JF. Wilson, MK. Wojczynski, C. Wong, TY. Wong, L. Xu, Q. Yang, M. Yasuda, LM. Yerges-Armstrong, W. Zhang, AB. Zonderman, JI. Rotter, M. Bochud, BM. Psaty, V. Vitart, JG. Wilson, A. Dehghan, A. Parsa, DI. Chasman, K. Ho, AP. Morris, O. Devuyst, S. Akilesh, SA. Pendergrass, X. Sim, CA. Böger, Y. Okada, TL. Edwards, H. Snieder, K. Stefansson, AM. Hung, IM. Heid, M. Scholz, A. Teumer, A. Köttgen, C. Pattaro,
520    9_
$a Chronic kidney disease (CKD) is responsible for a public health burden with multi-systemic complications. Through trans-ancestry meta-analysis of genome-wide association studies of estimated glomerular filtration rate (eGFR) and independent replication (n = 1,046,070), we identified 264 associated loci (166 new). Of these, 147 were likely to be relevant for kidney function on the basis of associations with the alternative kidney function marker blood urea nitrogen (n = 416,178). Pathway and enrichment analyses, including mouse models with renal phenotypes, support the kidney as the main target organ. A genetic risk score for lower eGFR was associated with clinically diagnosed CKD in 452,264 independent individuals. Colocalization analyses of associations with eGFR among 783,978 European-ancestry individuals and gene expression across 46 human tissues, including tubulo-interstitial and glomerular kidney compartments, identified 17 genes differentially expressed in kidney. Fine-mapping highlighted missense driver variants in 11 genes and kidney-specific regulatory variants. These results provide a comprehensive priority list of molecular targets for translational research.
650    _2
$a mapování chromozomů $7 D002874
650    _2
$a běloši $7 D044465
650    _2
$a genetické asociační studie $x metody $7 D056726
650    12
$a genetická predispozice k nemoci $7 D020022
650    _2
$a celogenomová asociační studie $7 D055106
650    _2
$a hodnoty glomerulární filtrace $7 D005919
650    _2
$a lidé $7 D006801
650    _2
$a typy dědičnosti $7 D040582
650    _2
$a vyšetření funkce ledvin $7 D007677
650    _2
$a fenotyp $7 D010641
650    _2
$a jednonukleotidový polymorfismus $7 D020641
650    12
$a lokus kvantitativního znaku $7 D040641
650    12
$a kvantitativní znak dědičný $7 D019655
650    _2
$a chronická renální insuficience $x genetika $x patofyziologie $x moč $7 D051436
650    _2
$a uromodulin $x moč $7 D058949
655    _2
$a časopisecké články $7 D016428
655    _2
$a metaanalýza $7 D017418
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Li, Yong $u Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
700    1_
$a Li, Man $u Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
700    1_
$a Sieber, Karsten B $u Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
700    1_
$a Feitosa, Mary F $u Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
700    1_
$a Gorski, Mathias $u Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
700    1_
$a Tin, Adrienne $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA.
700    1_
$a Wang, Lihua $u Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
700    1_
$a Chu, Audrey Y $u Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
700    1_
$a Hoppmann, Anselm $u Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
700    1_
$a Kirsten, Holger $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
700    1_
$a Giri, Ayush $u Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
700    1_
$a Chai, Jin-Fang $u Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
700    1_
$a Sveinbjornsson, Gardar $u deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
700    1_
$a Tayo, Bamidele O $u Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA.
700    1_
$a Nutile, Teresa $u Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy.
700    1_
$a Fuchsberger, Christian $u Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
700    1_
$a Marten, Jonathan $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
700    1_
$a Cocca, Massimiliano $u Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
700    1_
$a Ghasemi, Sahar $u Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
700    1_
$a Xu, Yizhe $u Division of Nephrology and Hypertension, Department of Medicine, University of Utah, Salt Lake City, USA.
700    1_
$a Horn, Katrin $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
700    1_
$a Noce, Damia $u Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
700    1_
$a van der Most, Peter J $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Sedaghat, Sanaz $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
700    1_
$a Yu, Zhi $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
700    1_
$a Akiyama, Masato $u Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
700    1_
$a Afaq, Saima $u Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan.
700    1_
$a Ahluwalia, Tarunveer S $u Steno Diabetes Center Copenhagen, Gentofte, Denmark.
700    1_
$a Almgren, Peter $u Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
700    1_
$a Amin, Najaf $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
700    1_
$a Ärnlöv, Johan $u Division of Family Medicine and Primary Care, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. School of Health and Social Studies, Dalarna University, Stockholm, Sweden.
700    1_
$a Bakker, Stephan J L $u Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Bansal, Nisha $u Division of Nephrology, University of Washington, Seattle, WA, USA. Kidney Research Institute, University of Washington, Seattle, WA, USA.
700    1_
$a Baptista, Daniela $u Cardiology, Geneva University Hospitals, Geneva, Switzerland.
700    1_
$a Bergmann, Sven $u Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. Swiss Institute of Bioinformatics, Lausanne, Switzerland. Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa.
700    1_
$a Biggs, Mary L $u Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. Department of Biostatistics, University of Washington, Seattle, WA, USA.
700    1_
$a Biino, Ginevra $u Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
700    1_
$a Boehnke, Michael $u Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
700    1_
$a Boerwinkle, Eric $u Human Genetics Center, University of Texas Health Science Center, Houston, TX, USA.
700    1_
$a Boissel, Mathilde $u CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
700    1_
$a Bottinger, Erwin P $u Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Digital Health Center, Hasso Plattner Institute and University of Potsdam, Potsdam, Germany.
700    1_
$a Boutin, Thibaud S $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
700    1_
$a Brenner, Hermann $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Network Aging Research, University of Heidelberg, Heidelberg, Germany.
700    1_
$a Brumat, Marco $u Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
700    1_
$a Burkhardt, Ralph $u LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany.
700    1_
$a Butterworth, Adam S $u MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
700    1_
$a Campana, Eric $u Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
700    1_
$a Campbell, Archie $u Center for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
700    1_
$a Campbell, Harry $u Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
700    1_
$a Canouil, Mickaël $u CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France.
700    1_
$a Carroll, Robert J $u Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
700    1_
$a Catamo, Eulalia $u Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
700    1_
$a Chambers, John C $u Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. Department of Cardiology, Ealing Hospital, Middlesex, UK. Imperial College Healthcare NHS Trust, Imperial College London, London, UK. MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
700    1_
$a Chee, Miao-Ling $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
700    1_
$a Chee, Miao-Li $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
700    1_
$a Chen, Xu $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
700    1_
$a Cheng, Ching-Yu $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Ophthalmology and Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
700    1_
$a Cheng, Yurong $u Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany.
700    1_
$a Christensen, Kaare $u Unit of Epidemiology, Biostatistics and Biodemography, Department of Public Health, Southern Denmark University, Odense, Denmark.
700    1_
$a Cifkova, Renata $u Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic. Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic.
700    1_
$a Ciullo, Marina $u Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy. IRCCS Neuromed, Pozzilli, Italy.
700    1_
$a Concas, Maria Pina $u Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
700    1_
$a Cook, James P $u Department of Biostatistics, University of Liverpool, Liverpool, UK.
700    1_
$a Coresh, Josef $u Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
700    1_
$a Corre, Tanguy $u Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. Swiss Institute of Bioinformatics, Lausanne, Switzerland. Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
700    1_
$a Sala, Cinzia Felicita $u San Raffaele Research Institute, Milan, Italy.
700    1_
$a Cusi, Daniele $u Institute of Biomedical Technologies, National Research Council of Italy, Milan, Italy. Bio4Dreams-Business Nursery for Life Sciences, Milan, Italy.
700    1_
$a Danesh, John $u Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
700    1_
$a Daw, E Warwick $u Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
700    1_
$a de Borst, Martin H $u Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a De Grandi, Alessandro $u Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
700    1_
$a de Mutsert, Renée $u Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands.
700    1_
$a de Vries, Aiko P J $u Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
700    1_
$a Degenhardt, Frauke $u Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
700    1_
$a Delgado, Graciela $u Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
700    1_
$a Demirkan, Ayse $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
700    1_
$a Di Angelantonio, Emanuele $u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. NHS Blood and Transplant, Cambridge, UK.
700    1_
$a Dittrich, Katalin $u Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
700    1_
$a Divers, Jasmin $u Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
700    1_
$a Dorajoo, Rajkumar $u Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
700    1_
$a Eckardt, Kai-Uwe $u Intensive Care Medicine, Charité, Berlin, Germany. Department of Nephrology and Hypertension, Friedrich Alexander University Erlangen-Nürnberg (FAU), Erlangen, Germany.
700    1_
$a Ehret, Georg $u Cardiology, Geneva University Hospitals, Geneva, Switzerland.
700    1_
$a Elliott, Paul $u Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. Imperial College NIHR Biomedical Research Center, Imperial College London, London, UK. Dementia Research Institute, Imperial College London, London, UK. Health Data Research UK-London, London, UK.
700    1_
$a Endlich, Karlhans $u DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.
700    1_
$a Evans, Michele K $u Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
700    1_
$a Felix, Janine F $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
700    1_
$a Foo, Valencia Hui Xian $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
700    1_
$a Franco, Oscar H $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Institute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
700    1_
$a Franke, Andre $u Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
700    1_
$a Freedman, Barry I $u Section on Nephrology, Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC, USA.
700    1_
$a Freitag-Wolf, Sandra $u Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
700    1_
$a Friedlander, Yechiel $u School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.
700    1_
$a Froguel, Philippe $u CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille, France. Department of Genomics of Common Disease, Imperial College London, London, UK.
700    1_
$a Gansevoort, Ron T $u Division of Nephrology, Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Gao, He $u Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
700    1_
$a Gasparini, Paolo $u Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
700    1_
$a Gaziano, J Michael $u Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA.
700    1_
$a Giedraitis, Vilmantas $u Molecular Geriatrics, Department of Public Health and Caring Sciences, Uppsala University, Uppsala, Sweden.
700    1_
$a Gieger, Christian $u Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. German Center for Diabetes Research (DZD), Neuherberg, Germany.
700    1_
$a Girotto, Giorgia $u Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy. Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
700    1_
$a Giulianini, Franco $u Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
700    1_
$a Gögele, Martin $u Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
700    1_
$a Gordon, Scott D $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
700    1_
$a Gudbjartsson, Daniel F $u deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
700    1_
$a Gudnason, Vilmundur $u Icelandic Heart Association, Kopavogur, Iceland. Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
700    1_
$a Haller, Toomas $u Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
700    1_
$a Hamet, Pavel $u Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada. Medpharmgene, Montreal, Quebec, Canada.
700    1_
$a Harris, Tamara B $u Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Bethesda, MD, USA.
700    1_
$a Hartman, Catharina A $u Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Hayward, Caroline $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
700    1_
$a Hellwege, Jacklyn N $u Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA.
700    1_
$a Heng, Chew-Kiat $u Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Khoo Teck Puat-National University Children's Medical Institute, National University Health System, Singapore, Singapore.
700    1_
$a Hicks, Andrew A $u Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
700    1_
$a Hofer, Edith $u Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria.
700    1_
$a Huang, Wei $u Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center, Shanghai, China. Shanghai Industrial Technology Institute, Shanghai, China.
700    1_
$a Hutri-Kähönen, Nina $u Department of Pediatrics, Tampere University Hospital, Tampere, Finland. Department of Pediatrics, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
700    1_
$a Hwang, Shih-Jen $u NHLBI's Framingham Heart Study, Framingham, MA, USA. The Center for Population Studies, NHLBI, Framingham, MA, USA.
700    1_
$a Ikram, M Arfan $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
700    1_
$a Indridason, Olafur S $u Division of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
700    1_
$a Ingelsson, Erik $u Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA.
700    1_
$a Ising, Marcus $u Max Planck Institute of Psychiatry, Munich, Germany.
700    1_
$a Jaddoe, Vincent W V $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
700    1_
$a Jakobsdottir, Johanna $u The Center of Public Health Sciences, University of Iceland, Reykjavík, Iceland.
700    1_
$a Jonas, Jost B $u Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim, Germany. Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
700    1_
$a Joshi, Peter K $u Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
700    1_
$a Josyula, Navya Shilpa $u Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA.
700    1_
$a Jung, Bettina $u Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
700    1_
$a Kähönen, Mika $u Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. Department of Clinical Physiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
700    1_
$a Kamatani, Yoichiro $u Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan.
700    1_
$a Kammerer, Candace M $u Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
700    1_
$a Kanai, Masahiro $u Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Yokohama, Japan. Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
700    1_
$a Kastarinen, Mika $u Department of Medicine, Kuopio University Hospital, Kuopio, Finland.
700    1_
$a Kerr, Shona M $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
700    1_
$a Khor, Chiea-Chuen $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore.
700    1_
$a Kiess, Wieland $u LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
700    1_
$a Kleber, Marcus E $u Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
700    1_
$a Koenig, Wolfgang $u Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany.
700    1_
$a Kooner, Jaspal S $u Department of Cardiology, Ealing Hospital, Middlesex, UK. Imperial College Healthcare NHS Trust, Imperial College London, London, UK. MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. National Heart and Lung Institute, Imperial College London, London, UK.
700    1_
$a Körner, Antje $u LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. Center for Pediatric Research, University of Leipzig, Leipzig, Germany.
700    1_
$a Kovacs, Peter $u Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Leipzig, Germany.
700    1_
$a Kraja, Aldi T $u Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
700    1_
$a Krajcoviechova, Alena $u Center for Cardiovascular Prevention, Charles University in Prague, First Faculty of Medicine and Thomayer Hospital, Prague, Czech Republic. Department of Medicine II, Charles University in Prague, First Faculty of Medicine, Prague, Czech Republic.
700    1_
$a Kramer, Holly $u Department of Public Health Sciences, Loyola University Chicago, Maywood, IL, USA. Division of Nephrology and Hypertension, Loyola University Chicago, Chicago, IL, USA.
700    1_
$a Krämer, Bernhard K $u Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
700    1_
$a Kronenberg, Florian $u Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria.
700    1_
$a Kubo, Michiaki $u RIKEN Center for Integrative Medical Sciences (IMS), Yokohama (Kanagawa), Japan.
700    1_
$a Kühnel, Brigitte $u Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany.
700    1_
$a Kuokkanen, Mikko $u The Department of Public Health Solutions, National Institute for Health and Welfare, Helsinki, Finland. Diabetes and Obesity Research Program, University of Helsinki, Helsinki, Finland.
700    1_
$a Kuusisto, Johanna $u Department of Medicine, Kuopio University Hospital, Kuopio, Finland. Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
700    1_
$a La Bianca, Martina $u Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
700    1_
$a Laakso, Markku $u Department of Medicine, Kuopio University Hospital, Kuopio, Finland. Institute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio, Finland.
700    1_
$a Lange, Leslie A $u Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA.
700    1_
$a Langefeld, Carl D $u Public Health Sciences-Biostatistics, Wake Forest School of Medicine, Winston-Salem, NC, USA.
700    1_
$a Lee, Jeannette Jen-Mai $u Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
700    1_
$a Lehne, Benjamin $u Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK.
700    1_
$a Lehtimäki, Terho $u Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
700    1_
$a Lieb, Wolfgang $u Institute of Epidemiology and Biobank Popgen, Kiel University, Kiel, Germany.
700    1_
$a Lim, Su-Chi $u Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. Diabetes Center, Khoo Teck Puat Hospital, Singapore, Singapore.
700    1_
$a Lind, Lars $u Cardiovascular Epidemiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
700    1_
$a Lindgren, Cecilia M $u Nuffield Department of Medicine, University of Oxford, Oxford, UK. Broad Institute of Harvard and MIT, Cambridge, MA, USA.
700    1_
$a Liu, Jun $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
700    1_
$a Liu, Jianjun $u Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
700    1_
$a Loeffler, Markus $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
700    1_
$a Loos, Ruth J F $u Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
700    1_
$a Lucae, Susanne $u Max Planck Institute of Psychiatry, Munich, Germany.
700    1_
$a Lukas, Mary Ann $u Target Sciences-Genetics, GlaxoSmithKline, Albuquerque, NM, USA.
700    1_
$a Lyytikäinen, Leo-Pekka $u Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
700    1_
$a Mägi, Reedik $u Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
700    1_
$a Magnusson, Patrik K E $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
700    1_
$a Mahajan, Anubha $u Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK. Oxford Center for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
700    1_
$a Martin, Nicholas G $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
700    1_
$a Martins, Jade $u Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.
700    1_
$a März, Winfried $u Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. Medical Clinic V, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
700    1_
$a Mascalzoni, Deborah $u Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
700    1_
$a Matsuda, Koichi $u Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
700    1_
$a Meisinger, Christa $u Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. Chair of Epidemiology, Ludwig- Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany.
700    1_
$a Meitinger, Thomas $u DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany. Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. Institute of Human Genetics, Technische Universität München, Munich, Germany.
700    1_
$a Melander, Olle $u Hypertension and Cardiovascular Disease, Department of Clincial Sciences Malmö, Lund University, Malmö, Sweden.
700    1_
$a Metspalu, Andres $u Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia.
700    1_
$a Mikaelsdottir, Evgenia K $u deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
700    1_
$a Milaneschi, Yuri $u Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
700    1_
$a Miliku, Kozeta $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
700    1_
$a Mishra, Pashupati P $u Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
700    1_
$a Mohlke, Karen L $u Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
700    1_
$a Mononen, Nina $u Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. Department of Clinical Chemistry, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
700    1_
$a Montgomery, Grant W $u Institute for Molecular Bioscience, University of Queensland, St Lucia, Queensland, Australia.
700    1_
$a Mook-Kanamori, Dennis O $u Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
700    1_
$a Mychaleckyj, Josyf C $u Center for Public Health Genomics, University of Virginia, Charlottesville, Charlottesville, VA, USA.
700    1_
$a Nadkarni, Girish N $u Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
700    1_
$a Nalls, Mike A $u Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. Data Tecnica International, Glen Echo, MD, USA.
700    1_
$a Nauck, Matthias $u DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
700    1_
$a Nikus, Kjell $u Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Life Sciences, Tampere University, Tampere, Finland.
700    1_
$a Ning, Boting $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
700    1_
$a Nolte, Ilja M $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Noordam, Raymond $u Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.
700    1_
$a O'Connell, Jeffrey $u University of Maryland School of Medicine, Baltimore, MD, USA.
700    1_
$a O'Donoghue, Michelle L $u Cardiovascular Division, Brigham and Women's Hospital, Boston, MA, USA. TIMI Study Group, Boston, MA, USA.
700    1_
$a Olafsson, Isleifur $u Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland.
700    1_
$a Oldehinkel, Albertine J $u Interdisciplinary Center of Psychopathology and Emotion Regulation (ICPE), University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Orho-Melander, Marju $u Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
700    1_
$a Ouwehand, Willem H $u Department of Public Health and Primary Care, School of Clinical Medicine, University of Cambridge, Cambridge, UK.
700    1_
$a Padmanabhan, Sandosh $u Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.
700    1_
$a Palmer, Nicholette D $u Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC, USA.
700    1_
$a Palsson, Runolfur $u Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. Division of Nephrology, Internal Medicine Services, Landspitali-The National University Hospital of Iceland, Reykjavik, Iceland.
700    1_
$a Penninx, Brenda W J H $u Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
700    1_
$a Perls, Thomas $u Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA.
700    1_
$a Perola, Markus $u National Institute for Health and Welfare, Helsinki, Finland.
700    1_
$a Pirastu, Mario $u Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
700    1_
$a Pirastu, Nicola $u Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
700    1_
$a Pistis, Giorgio $u Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland.
700    1_
$a Podgornaia, Anna I $u Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
700    1_
$a Polasek, Ozren $u Faculty of Medicine, University of Split, Split, Croatia. Gen-info Ltd, Zagreb, Croatia.
700    1_
$a Ponte, Belen $u Service de Néphrologie, Geneva University Hospitals, Geneva, Switzerland.
700    1_
$a Porteous, David J $u Center for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Center for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
700    1_
$a Poulain, Tanja $u LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
700    1_
$a Pramstaller, Peter P $u Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy.
700    1_
$a Preuss, Michael H $u Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
700    1_
$a Prins, Bram P $u MRC/BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
700    1_
$a Province, Michael A $u Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
700    1_
$a Rabelink, Ton J $u Section of Nephrology, Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Center, Leiden, the Netherlands.
700    1_
$a Raffield, Laura M $u Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
700    1_
$a Raitakari, Olli T $u Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. Research Center of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.
700    1_
$a Reilly, Dermot F $u Genetics, Merck & Co., Inc, Kenilworth, NJ, USA.
700    1_
$a Rettig, Rainer $u Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany.
700    1_
$a Rheinberger, Myriam $u Department of Nephrology, University Hospital Regensburg, Regensburg, Germany.
700    1_
$a Rice, Kenneth M $u Department of Biostatistics, University of Washington, Seattle, WA, USA.
700    1_
$a Ridker, Paul M $u Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. Harvard Medical School, Boston, MA, USA.
700    1_
$a Rivadeneira, Fernando $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
700    1_
$a Rizzi, Federica $u Department of Health Sciences, University of Milan, Milano, Italy. ePhood Scientific Unit, ePhood SRL, Milano, Italy.
700    1_
$a Roberts, David J $u NHS Blood and Transplant, BRC Oxford Haematology Theme; Nuffield Division of Clinical Laboratory Sciences; University of Oxford, Oxford, UK.
700    1_
$a Robino, Antonietta $u Institute for Maternal and Child Health, IRCCS 'Burlo Garofolo', Trieste, Italy.
700    1_
$a Rossing, Peter $u Steno Diabetes Center Copenhagen, Gentofte, Denmark.
700    1_
$a Rudan, Igor $u Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
700    1_
$a Rueedi, Rico $u Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. Swiss Institute of Bioinformatics, Lausanne, Switzerland.
700    1_
$a Ruggiero, Daniela $u Institute of Genetics and Biophysics 'Adriano Buzzati-Traverso'-CNR, Naples, Italy. IRCCS Neuromed, Pozzilli, Italy.
700    1_
$a Ryan, Kathleen A $u Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA.
700    1_
$a Saba, Yasaman $u Molecular Biology and Biochemistry, Gottfried Schatz Research Center for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria.
700    1_
$a Sabanayagam, Charumathi $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
700    1_
$a Salomaa, Veikko $u National Institute for Health and Welfare, Helsinki, Finland.
700    1_
$a Salvi, Erika $u Department of Health Sciences, University of Milan, Milano, Italy. Neuroalgology Unit, Fondazione IRCCS Istituto Neurologico 'Carlo Besta', Milan, Italy.
700    1_
$a Saum, Kai-Uwe $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
700    1_
$a Schmidt, Helena $u Institute of Molecular Biology and Biochemistry, Center for Molecular Medicine, Medical University of Graz, Graz, Austria.
700    1_
$a Schmidt, Reinhold $u Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria.
700    1_
$a Schöttker, Ben $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. Network Aging Research, University of Heidelberg, Heidelberg, Germany.
700    1_
$a Schulz, Christina-Alexandra $u Diabetes and Cardiovascular Disease-Genetic Epidemiology, Department of Clincial Sciences in Malmö, Lund University, Malmö, Sweden.
700    1_
$a Schupf, Nicole $u Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA. Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, USA.
700    1_
$a Shaffer, Christian M $u Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA.
700    1_
$a Shi, Yuan $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
700    1_
$a Smith, Albert V $u Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland.
700    1_
$a Smith, Blair H $u Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
700    1_
$a Soranzo, Nicole $u Human Genetics, Wellcome Sanger Institute, Hinxton, UK.
700    1_
$a Spracklen, Cassandra N $u Department of Genetics, University of North Carolina, Chapel Hill, NC, USA.
700    1_
$a Strauch, Konstantin $u Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-Universität München, München, Germany.
700    1_
$a Stringham, Heather M $u Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
700    1_
$a Stumvoll, Michael $u Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
700    1_
$a Svensson, Per O $u Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden. Department of Cardiology, Södersjukhuset, Stockholm, Sweden.
700    1_
$a Szymczak, Silke $u Institute of Medical Informatics and Statistics, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
700    1_
$a Tai, E-Shyong $u Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore. Duke-NUS Medical School, Singapore, Singapore.
700    1_
$a Tajuddin, Salman M $u Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
700    1_
$a Tan, Nicholas Y Q $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
700    1_
$a Taylor, Kent D $u The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA.
700    1_
$a Teren, Andrej $u LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Heart Center Leipzig, Leipzig, Germany.
700    1_
$a Tham, Yih-Chung $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore.
700    1_
$a Thiery, Joachim $u LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany. Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany.
700    1_
$a Thio, Chris H L $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Thomsen, Hauke $u Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
700    1_
$a Thorleifsson, Gudmar $u deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
700    1_
$a Toniolo, Daniela $u San Raffaele Research Institute, Milan, Italy.
700    1_
$a Tönjes, Anke $u Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany.
700    1_
$a Tremblay, Johanne $u Montreal University Hospital Research Center, CHUM, Montreal, Quebec, Canada. CRCHUM, Montreal, Canada.
700    1_
$a Tzoulaki, Ioanna $u Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece.
700    1_
$a Uitterlinden, André G $u Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
700    1_
$a Vaccargiu, Simona $u Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Li Punti, Sassari, Italy.
700    1_
$a van Dam, Rob M $u Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
700    1_
$a van der Harst, Pim $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. Durrer Center for Cardiovascular Research, The Netherlands Heart Institute, Utrecht, the Netherlands.
700    1_
$a van Duijn, Cornelia M $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
700    1_
$a Velez Edward, Digna R $u Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. Department of Obstetrics and Gynecology, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.
700    1_
$a Verweij, Niek $u Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Vogelezang, Suzanne $u Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
700    1_
$a Völker, Uwe $u DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany.
700    1_
$a Vollenweider, Peter $u Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
700    1_
$a Waeber, Gerard $u Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland.
700    1_
$a Waldenberger, Melanie $u Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany.
700    1_
$a Wallentin, Lars $u Cardiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
700    1_
$a Wang, Ya Xing $u Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
700    1_
$a Wang, Chaolong $u Genome Institute of Singapore, Agency for Science Technology and Research, Singapore, Singapore. School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
700    1_
$a Waterworth, Dawn M $u Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
700    1_
$a Bin Wei, Wen $u Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
700    1_
$a White, Harvey $u Green Lane Cardiovascular Service, Auckland City Hospital and University of Auckland, Auckland, New Zealand.
700    1_
$a Whitfield, John B $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
700    1_
$a Wild, Sarah H $u Center for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
700    1_
$a Wilson, James F $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. Center for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
700    1_
$a Wojczynski, Mary K $u Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA.
700    1_
$a Wong, Charlene $u Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
700    1_
$a Wong, Tien-Yin $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore.
700    1_
$a Xu, Liang $u Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
700    1_
$a Yang, Qiong $u Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
700    1_
$a Yasuda, Masayuki $u Singapore Eye Research Institute, Singapore National Eye Center, Singapore, Singapore. Department of Ophthalmology, Tohoku University Graduate School of Medicine, Miyagi, Japan.
700    1_
$a Yerges-Armstrong, Laura M $u Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA.
700    1_
$a Zhang, Weihua $u Department of Cardiology, Ealing Hospital, Middlesex, UK. Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
700    1_
$a Zonderman, Alan B $u Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, US National Institutes of Health, Baltimore, MD, USA.
700    1_
$a Rotter, Jerome I $u The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA, USA. Department of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
700    1_
$a Bochud, Murielle $u Institute of Social and Preventive Medicine, Lausanne University Hospital, Lausanne, Switzerland.
700    1_
$a Psaty, Bruce M $u Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA.
700    1_
$a Vitart, Veronique $u Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
700    1_
$a Wilson, James G $u Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS, USA.
700    1_
$a Dehghan, Abbas $u Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. Department of Epidemiology and Biostatistics, MRC-PHE Center for Environment and Health, School of Public Health, Imperial College London, London, UK.
700    1_
$a Parsa, Afshin $u Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
700    1_
$a Chasman, Daniel I $u Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA. Harvard Medical School, Boston, MA, USA.
700    1_
$a Ho, Kevin $u Kidney Health Research Institute (KHRI), Geisinger, Danville, PA, USA. Department of Nephrology, Geisinger, Danville, PA, USA.
700    1_
$a Morris, Andrew P $u Department of Biostatistics, University of Liverpool, Liverpool, UK. Wellcome Trust Center for Human Genetics, University of Oxford, Oxford, UK.
700    1_
$a Devuyst, Olivier $u Institute of Physiology, University of Zurich, Zurich, Switzerland.
700    1_
$a Akilesh, Shreeram $u Kidney Research Institute, University of Washington, Seattle, WA, USA. Anatomic Pathology, University of Washington Medical Center, Seattle, WA, USA.
700    1_
$a Pendergrass, Sarah A $u Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA.
700    1_
$a Sim, Xueling $u Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore.
700    1_
$a Böger, Carsten A $u Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. Department of Nephrology and Rheumatology, Kliniken Südostbayern, Regensburg, Germany.
700    1_
$a Okada, Yukinori $u Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences (IMS), Osaka, Japan. Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan.
700    1_
$a Edwards, Todd L $u Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
700    1_
$a Snieder, Harold $u Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
700    1_
$a Stefansson, Kari $u deCODE Genetics/Amgen, Inc., Reykjavik, Iceland.
700    1_
$a Hung, Adriana M $u Department of Veteran's Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. Vanderbilt University Medical Center, Division of Nephrology & Hypertension, Nashville, TN, USA.
700    1_
$a Heid, Iris M $u Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany.
700    1_
$a Scholz, Markus $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. LIFE Research Center for Civilization Diseases, University of Leipzig, Leipzig, Germany.
700    1_
$a Teumer, Alexander $u Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald, Germany.
700    1_
$a Köttgen, Anna $u Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de.
700    1_
$a Pattaro, Cristian $u Eurac Research, Institute for Biomedicine (affiliated with the University of Lübeck), Bolzano, Italy. cristian.pattaro@eurac.edu.
710    2_
$a Lifelines Cohort Study
710    2_
$a V. A. Million Veteran Program
773    0_
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