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Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures
D. Veréb, N. Szabó, B. Tuka, J. Tajti, A. Király, P. Faragó, K. Kocsis, E. Tóth, B. Kincses, T. Bagoly, Z. Helyes, L. Vécsei, ZT. Kincses,
Language English Country United States
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Anisotropy MeSH
- White Matter pathology MeSH
- Biomarkers MeSH
- Adult MeSH
- Pituitary Adenylate Cyclase-Activating Polypeptide blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Migraine Disorders blood diagnostic imaging pathology MeSH
- Young Adult MeSH
- Brain pathology MeSH
- Neuroimaging MeSH
- Diffusion Tensor Imaging MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
OBJECTIVE: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. METHODS: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library. RESULTS: Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01). CONCLUSION: We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.
Central European Institute of Technology Brno Czech Republic
Department of Pharmacology and Pharmacotherapy Faculty of Medicine University of Pécs Hungary
From the Departments of Neurology Albert Szent Györgyi Clinical Center University of Szeged Hungary
References provided by Crossref.org
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- $a Veréb, Dániel $u From the Departments of Neurology (D.V., N.S., J.T., A.K., P.F., K.K., E.T., B.K., L.V., Z.T.K.) and Radiology (Z.T.K.), Albert Szent-Györgyi Clinical Center, University of Szeged, Hungary; Central European Institute of Technology (N.S., A.K.), Brno, Czech Republic; MTA-SZTE Neuroscience Research Group (B.T., L.V.), Szeged; and Department of Pharmacology and Pharmacotherapy, Faculty of Medicine (T.B., Z.H.), and János Szentágothai Research Centre & Centre for Neuroscience (Z.H.), University of Pécs, Hungary.
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- $a Correlation of neurochemical and imaging markers in migraine: PACAP38 and DTI measures / $c D. Veréb, N. Szabó, B. Tuka, J. Tajti, A. Király, P. Faragó, K. Kocsis, E. Tóth, B. Kincses, T. Bagoly, Z. Helyes, L. Vécsei, ZT. Kincses,
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- $a OBJECTIVE: To examine whether interictal plasma pituitary adenylate cyclase-activating peptide 38-like immunoreactivity (PACAP38-LI) shows correlation with the microstructural integrity of the white matter in migraine. METHODS: Interictal plasma PACAP38-LI was measured by radioimmunoassay in 26 patients with migraine (24 women) who underwent diffusion tensor imaging afterward using a 1.5-tesla magnetic resonance scanner. Data were analyzed using tract-based spatial statistics included in FMRIB's Software Library. RESULTS: Interictal plasma PACAP38-LI showed significant correlation with mean diffusivity (p < 0.0179) mostly in the bilateral occipital white matter spreading into parietal and temporal white matter. Axial and radial diffusivity showed positive correlation with interictal PACAP38-LI (p < 0.0432 and p < 0.0418, respectively) in the left optic radiation and left posterior corpus callosum. Fractional anisotropy did not correlate significantly with PACAP38-LI. With disease duration as a nuisance regressor in the model, PACAP38-LI correlated with axial and mean diffusivity in the left thalamus (p < 0.01). CONCLUSION: We report a link between PACAP38, a pathobiologically important neurochemical biomarker, and imaging markers of the disease that may bolster further research into the role of PACAP38 in migraine.
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