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Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study
JL. Kalman, S. Papiol, AJ. Forstner, U. Heilbronner, F. Degenhardt, J. Strohmaier, M. Adli, K. Adorjan, N. Akula, M. Alda, H. Anderson-Schmidt, TF. Andlauer, IG. Anghelescu, R. Ardau, B. Arias, V. Arolt, JM. Aubry, L. Backlund, K. Bartholdi, M....
Jazyk angličtina Země Dánsko
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc19035159
PubMed
29956436
DOI
10.1111/bdi.12659
Knihovny.cz E-zdroje
- MeSH
- bipolární porucha genetika MeSH
- dítě MeSH
- dospělí MeSH
- fenotyp MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- multifaktoriální dědičnost MeSH
- schizofrenie genetika MeSH
- věkové faktory MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
OBJECTIVES: Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients. METHODS: A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18 years] vs adulthood [>18 years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models. RESULTS: BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment. CONCLUSIONS: The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.
AMEOS Clinical Center Hildesheim Hildesheim Germany
AMEOS Clinical Center Osnabrück Osnabrück Germany
Asklepios Specialized Hospital Göttingen Germany
ASKLEPIOS Specialized Hospital Tiefenbrunn Rosdorf Germany
Clinic for Psychiatry and Psychotherapy Clinical Center Werra Meißner Eschwege Germany
Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Biomedical Sciences University of Cagliari Cagliari Italy
Department of Clinical Neurosciences Karolinska Institutet Stockholm Sweden
Department of Pharmacy VA San Diego Healthcare System San Diego CA USA
Department of Psychiatry 2 Ulm University Bezirkskrankenhaus Günzburg Günzburg Germany
Department of Psychiatry and Behavioral Sciences Johns Hopkins University Baltimore MD USA
Department of Psychiatry and Psychotherapy Agaplesion Diakonieklinikum Rotenburg Germany
Department of Psychiatry and Psychotherapy Bezirkskrankenhaus Augsburg Augsburg Germany
Department of Psychiatry and Psychotherapy Charité Universitätsmedizin Berlin Berlin Germany
Department of Psychiatry and Psychotherapy Ludwig Maximilians University Munich Munich Germany
Department of Psychiatry Campania University L Vanvitelli Naples Italy
Department of Psychiatry Dalhousie University Halifax NS Canada
Department of Psychiatry Karolinska Institutet Stockholm Sweden
Department of Psychiatry Klinikum Bremen Ost Bremen Germany
Department of Psychiatry Ruhr University Bochum LWL University Hospital Bochum Germany
Department of Psychiatry University of California San Diego San Diego CA USA
Department of Psychiatry University of Münster Münster Germany
Department of Psychiatry University of Perugia Perugia Italy
Douglas Hospital Verdun QC Canada
Hospital Neunkirchen Neunkirchen Germany
INSERM U955 Equipe 15 Psychiatrie Genetique Hopital Henri Mondor Creteil Cedex France
Institute of Psychiatric Phenomics and Genomics Barcelona Spain
Institute of Psychiatric Phenomics and Genomics Georg August University Göttingen Göttingen Germany
Institute of Psychiatric Phenomics and Genomics Munich Germany
Institute of Psychiatric Phenomics and Genomics University Hospital LMU Munich Munich Germany
Karl Jaspers Clinic European Medical School Oldenburg Groningen Oldenburg Germany
Laboratory of Psychiatric Genetics Poznan University of Medical Sciences Poznan Poland
Lindner Center of HOPE Research Institute Mason OH USA
Max Planck Institute of Psychiatry Munich Germany
Medical University of Graz Graz Austria
Mental Health Program IMIM CIBERSAM Barcelona Catolonia Spain
Mood Disorders Program McGill University Health Centre Montreal QC Canada
Mood Disorders Unit Department of Psychiatry HUG Geneva University Hospitals Geneva Switzerland
National Institute of Mental Health Klecany Czech Republic
Private Neuropathic Hospital Dr med Kurt Fontheim Liebenburg Germany
Psychiatric Hospital Lüneburg Lüneburg Germany
Psychiatry University of Iowa Iowa City IA USA
Sigmund Freud University Vienna Austria Bipolar Zentrum Wiener Neustadt Austria
Unit of Clinical Pharmacology Hospital University Agency of Cagliari Cagliari Italy
Unitat d'Antropologia Universitat de Barcelona CIBERSAM Barcelona Spain
Citace poskytuje Crossref.org
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- $a Kalman, Janos L $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany. International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
- 245 10
- $a Investigating polygenic burden in age at disease onset in bipolar disorder: Findings from an international multicentric study / $c JL. Kalman, S. Papiol, AJ. Forstner, U. Heilbronner, F. Degenhardt, J. Strohmaier, M. Adli, K. Adorjan, N. Akula, M. Alda, H. Anderson-Schmidt, TF. Andlauer, IG. Anghelescu, R. Ardau, B. Arias, V. Arolt, JM. Aubry, L. Backlund, K. Bartholdi, M. Bauer, BT. Baune, T. Becker, F. Bellivier, A. Benabarre, S. Bengesser, AK. Bhattacharjee, JM. Biernacka, A. Birner, C. Brichant-Petitjean, M. Budde, P. Cervantes, C. Chillotti, S. Cichon, SR. Clark, F. Colom, AL. Comes, C. Cruceanu, PM. Czerski, U. Dannlowski, A. Dayer, M. Del Zompo, JR. DePaulo, DE. Dietrich, B. Étain, T. Ethofer, P. Falkai, A. Fallgatter, C. Figge, L. Flatau, H. Folkerts, L. Frisen, MA. Frye, JM. Fullerton, K. Gade, S. Gard, JS. Garnham, FS. Goes, M. Grigoroiu-Serbanescu, A. Gryaznova, M. Hake, J. Hauser, S. Herms, P. Hoffmann, L. Hou, M. Jäger, S. Jamain, E. Jiménez, G. Juckel, JP. Kahn, L. Kassem, J. Kelsoe, S. Kittel-Schneider, S. Kliwicki, F. Klohn-Sagatholislam, M. Koller, B. König, C. Konrad, N. Lackner, G. Laje, M. Landén, FU. Lang, C. Lavebratt, M. Leboyer, SG. Leckband, M. Maj, M. Manchia, L. Martinsson, MJ. McCarthy, SL. McElroy, FJ. McMahon, PB. Mitchell, M. Mitjans, FM. Mondimore, P. Monteleone, V. Nieratschker, CM. Nievergelt, T. Novák, U. Ösby, A. Pfennig, JB. Potash, D. Reich-Erkelenz, A. Reif, J. Reimer, E. Reininghaus, M. Reitt, S. Ripke, GA. Rouleau, JK. Rybakowski, M. Schalling, H. Scherk, M. Schmauß, PR. Schofield, KO. Schubert, EC. Schulte, S. Schulz, F. Senner, G. Severino, T. Shekhtman, PD. Shilling, C. Simhandl, CM. Slaney, C. Spitzer, A. Squassina, T. Stamm, S. Stegmaier, S. Stierl, P. Stopkova, A. Thiel, SK. Tighe, A. Tortorella, G. Turecki, E. Vieta, J. Veeh, M. von Hagen, ME. Wigand, J. Wiltfang, S. Witt, A. Wright, PP. Zandi, J. Zimmermann, M. Nöthen, M. Rietschel, TG. Schulze,
- 520 9_
- $a OBJECTIVES: Bipolar disorder (BD) with early disease onset is associated with an unfavorable clinical outcome and constitutes a clinically and biologically homogenous subgroup within the heterogeneous BD spectrum. Previous studies have found an accumulation of early age at onset (AAO) in BD families and have therefore hypothesized that there is a larger genetic contribution to the early-onset cases than to late onset BD. To investigate the genetic background of this subphenotype, we evaluated whether an increased polygenic burden of BD- and schizophrenia (SCZ)-associated risk variants is associated with an earlier AAO in BD patients. METHODS: A total of 1995 BD type 1 patients from the Consortium of Lithium Genetics (ConLiGen), PsyCourse and Bonn-Mannheim samples were genotyped and their BD and SCZ polygenic risk scores (PRSs) were calculated using the summary statistics of the Psychiatric Genomics Consortium as a training data set. AAO was either separated into onset groups of clinical interest (childhood and adolescence [≤18 years] vs adulthood [>18 years]) or considered as a continuous measure. The associations between BD- and SCZ-PRSs and AAO were evaluated with regression models. RESULTS: BD- and SCZ-PRSs were not significantly associated with age at disease onset. Results remained the same when analyses were stratified by site of recruitment. CONCLUSIONS: The current study is the largest conducted so far to investigate the association between the cumulative BD and SCZ polygenic risk and AAO in BD patients. The reported negative results suggest that such a polygenic influence, if there is any, is not large, and highlight the importance of conducting further, larger scale studies to obtain more information on the genetic architecture of this clinically relevant phenotype.
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- 700 1_
- $a Papiol, Sergi $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany. Instituto de Salud Carlos III, Biomedical Network Research Centre on Mental Health (CIBERSAM), Barcelona, Spain.
- 700 1_
- $a Forstner, Andreas J $u Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany. Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
- $a Heilbronner, Urs $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
- 700 1_
- $a Degenhardt, Franziska $u Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
- 700 1_
- $a Strohmaier, Jana $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Adli, Mazda $u Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
- 700 1_
- $a Adorjan, Kristina $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
- 700 1_
- $a Akula, Nirmala $u Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA.
- 700 1_
- $a Alda, Martin $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
- 700 1_
- $a Anderson-Schmidt, Heike $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
- 700 1_
- $a Andlauer, Till Fm $u Max Planck Institute of Psychiatry, Munich, Germany.
- 700 1_
- $a Anghelescu, Ion-George $u Private Neuropathic Hospital Dr. med. Kurt Fontheim, Liebenburg, Germany.
- 700 1_
- $a Ardau, Raffaella $u Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
- 700 1_
- $a Arias, Bárbara $u Departament Biologia Evolutiva, Ecologia i Ciències Ambientals, Facultat de Biologia, Institut de Biomedicina de la Universitat de Barcelona (IBUB), CIBERSAM, Universitat de Barcelona, Barcelona, Spain.
- 700 1_
- $a Arolt, Volker $u Department of Psychiatry, University of Münster, Münster, Germany.
- 700 1_
- $a Aubry, Jean-Michel $u Mood Disorders Unit, Department of Psychiatry, HUG - Geneva University Hospitals, Geneva, Switzerland.
- 700 1_
- $a Backlund, Lena $u Department of Molecular Medicine and Surgery, Karolinska Institutet and The Centre for Psychiatric Research, Stockholm, Sweden.
- 700 1_
- $a Bartholdi, Kim $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
- 700 1_
- $a Bauer, Michael $u Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
- 700 1_
- $a Baune, Bernhard T $u Discipline of Psychiatry, Royal Adelaide Hospital, Adelaide School of Medical Schooline, The University of Adelaide, Adelaide, SA, Australia.
- 700 1_
- $a Becker, Thomas $u Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
- 700 1_
- $a Bellivier, Frank $u INSERM UMR-S 1144 - Université Paris Diderot, Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.
- 700 1_
- $a Benabarre, Antonio $u Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
- 700 1_
- $a Bengesser, Susanne $u Medical University of Graz, Graz, Austria.
- 700 1_
- $a Bhattacharjee, Abesh Kumar $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a Biernacka, Joanna M $u Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Birner, Armin $u Medical University of Graz, Graz, Austria.
- 700 1_
- $a Brichant-Petitjean, Clara $u INSERM UMR-S 1144 - Université Paris Diderot, Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.
- 700 1_
- $a Budde, Monika $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
- 700 1_
- $a Cervantes, Pablo $u Mood Disorders Program, McGill University Health Centre, Montreal, QC, Canada.
- 700 1_
- $a Chillotti, Caterina $u Unit of Clinical Pharmacology, Hospital University Agency of Cagliari, Cagliari, Italy.
- 700 1_
- $a Cichon, Sven $u Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany. Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
- $a Clark, Scott R $u Discipline of Psychiatry, Royal Adelaide Hospital, Adelaide School of Medical Schooline, The University of Adelaide, Adelaide, SA, Australia.
- 700 1_
- $a Colom, Francesc $u Mental Health Program, IMIM (Hospital del Mar Medical Research Institute), CIBERSAM Barcelona, Catolonia, Spain.
- 700 1_
- $a Comes, Ashley L $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. International Max Planck Research School for Translational Psychiatry (IMPRS-TP), Munich, Germany.
- 700 1_
- $a Cruceanu, Cristiana $u Max Planck Institute of Psychiatry, Munich, Germany. Mood Disorders Program, McGill University Health Centre, Montreal, QC, Canada.
- 700 1_
- $a Czerski, Piotr M $u Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Dannlowski, Udo $u Department of Psychiatry, University of Münster, Münster, Germany.
- 700 1_
- $a Dayer, Alexandre $u Mood Disorders Unit, Department of Psychiatry, HUG - Geneva University Hospitals, Geneva, Switzerland.
- 700 1_
- $a Del Zompo, Maria $u Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
- 700 1_
- $a DePaulo, Jay Raymond $u Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Dietrich, Detlef E $u AMEOS Clinical Center Hildesheim, Hildesheim, Germany.
- 700 1_
- $a Étain, Bruno $u INSERM UMR-S 1144 - Université Paris Diderot, Pôle de Psychiatrie, AP-HP, Groupe Hospitalier Lariboisière-F. Widal, Paris, France.
- 700 1_
- $a Ethofer, Thomas $u Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
- 700 1_
- $a Falkai, Peter $u Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
- 700 1_
- $a Fallgatter, Andreas $u Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
- 700 1_
- $a Figge, Christian $u Karl-Jaspers Clinic, European Medical School Oldenburg-Groningen, Oldenburg, Germany.
- 700 1_
- $a Flatau, Laura $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
- 700 1_
- $a Folkerts, Here $u Department of Psychiatry, Psychotherapy and Psychosomatics, Clinical Center Wilhelmshaven, Wilhelmshaven, Germany.
- 700 1_
- $a Frisen, Louise $u Department of Molecular Medicine and Surgery, Karolinska Institutet and The Centre for Psychiatric Research, Stockholm, Sweden.
- 700 1_
- $a Frye, Mark A $u Mayo Clinic, Rochester, MN, USA.
- 700 1_
- $a Fullerton, Janice M $u Neuroscience Research Australia, Sydney, NSW, Australia. School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
- 700 1_
- $a Gade, Katrin $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
- 700 1_
- $a Gard, Sébastien $u CH Ch Perrens, Bordeaux, France.
- 700 1_
- $a Garnham, Julie S $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
- 700 1_
- $a Goes, Fernando S $u Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Grigoroiu-Serbanescu, Maria $u Biometric Psychiatric Genetics Research Unit, Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania.
- 700 1_
- $a Gryaznova, Anna $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
- 700 1_
- $a Hake, Maria $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
- 700 1_
- $a Hauser, Joanna $u Laboratory of Psychiatric Genetics, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Herms, Stefan $u Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany. Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
- $a Hoffmann, Per $u Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany. Human Genomics Research Group, Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
- $a Hou, Liping $u Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA.
- 700 1_
- $a Jäger, Markus $u Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
- 700 1_
- $a Jamain, Stephane $u INSERM U955 Equipe 15 - Psychiatrie Genetique, Hopital Henri Mondor, Creteil, Cedex, France.
- 700 1_
- $a Jiménez, Esther $u Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
- 700 1_
- $a Juckel, Georg $u Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Bochum, Germany.
- 700 1_
- $a Kahn, Jean-Pierre $u Service de Psychiatrie et Psychologie Clinique, Centre Psychothérapique de Nancy - Université de Lorraine, Nancy, France.
- 700 1_
- $a Kassem, Layla $u Human Genetics Branch, Section on Genetic Basis of Mood and Anxiety Disorders, National Institutes of Health, Bethesda, MD, USA.
- 700 1_
- $a Kelsoe, John $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a Kittel-Schneider, Sarah $u Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
- 700 1_
- $a Kliwicki, Sebastian $u Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Klohn-Sagatholislam, Farah $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
- 700 1_
- $a Koller, Manfred $u Asklepios Specialized Hospital, Göttingen, Germany.
- 700 1_
- $a König, Barbara $u Hospital Neunkirchen, Neunkirchen, Germany.
- 700 1_
- $a Konrad, Carsten $u Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.
- 700 1_
- $a Lackner, Nina $u Medical University of Graz, Graz, Austria.
- 700 1_
- $a Laje, Gonzalo $u Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA.
- 700 1_
- $a Landén, Mikael $u Gothenburg University, Sahlgrenska Academy, Gothenburg, Sweden. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Lang, Fabian U $u Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
- 700 1_
- $a Lavebratt, Catharina $u CH Ch Perrens, Bordeaux, France.
- 700 1_
- $a Leboyer, Marion $u INSERM U955 Equipe 15 - Psychiatrie Genetique, Hopital Henri Mondor, Creteil, Cedex, France. Assistance Publique-Hôpitaux de Paris, Hôpital Albert Chenevier - Henri Mondor, Pôle de Psychiatrie, Créteil, France.
- 700 1_
- $a Leckband, Susan G $u Department of Pharmacy, VA San Diego Healthcare System, San Diego, CA, USA.
- 700 1_
- $a Maj, Mario $u Department of Psychiatry, Campania University L. Vanvitelli, Naples, Italy.
- 700 1_
- $a Manchia, Mirko $u Section of Psychiatry, Department of Public Health, Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy. Department of Pharmacology, Dalhousie University, Halifax, NS, Canada.
- 700 1_
- $a Martinsson, Lina $u Department of Clinical Neurosciences, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a McCarthy, Michael J $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a McElroy, Susan L $u Lindner Center of HOPE, Research Institute, Mason, OH, USA.
- 700 1_
- $a McMahon, Francis J $u Intramural Research Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA.
- 700 1_
- $a Mitchell, Philip B $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia. Black Dog Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
- 700 1_
- $a Mitjans, Marina $u Unitat d'Antropologia (Dp. Biología Animal), Department of Biologia Animal, Facultat de Biologia and Institut de Biomedicina (IBUB), Universitat de Barcelona, CIBERSAM, Barcelona, Spain.
- 700 1_
- $a Mondimore, Francis M $u Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Monteleone, Palmiero $u Department of Psychiatry, Campania University L. Vanvitelli, Naples, Italy. Neurosciences Section, Department of Medicine and Surgery, University of Salerno, Salerno, Italy.
- 700 1_
- $a Nieratschker, Vanessa $u Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
- 700 1_
- $a Nievergelt, Caroline M $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a Novák, Tomas $u National Institute of Mental Health, Klecany, Czech Republic. Third Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
- 700 1_
- $a Ösby, Urban $u Department of Psychiatry, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Pfennig, Andrea $u Department of Psychiatry and Psychotherapy, Carl Gustav Carus University Hospital, Technische Universität Dresden, Dresden, Germany.
- 700 1_
- $a Potash, James B $u Psychiatry, University of Iowa, Iowa City, IA, USA.
- 700 1_
- $a Reich-Erkelenz, Daniela $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
- 700 1_
- $a Reif, Andreas $u Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
- 700 1_
- $a Reimer, Jens $u Department of Psychiatry, Klinikum Bremen-Ost, Bremen, Germany.
- 700 1_
- $a Reininghaus, Eva $u Medical University of Graz, Graz, Austria.
- 700 1_
- $a Reitt, Markus $u Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
- 700 1_
- $a Ripke, Stephan $u Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany. Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA.
- 700 1_
- $a Rouleau, Guy A $u Mood Disorders Program, McGill University Health Centre, Montreal, QC, Canada.
- 700 1_
- $a Rybakowski, Janusz K $u Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Schalling, Martin $u Department of Molecular Medicine and Surgery, Karolinska Institutet and The Centre for Psychiatric Research, Stockholm, Sweden.
- 700 1_
- $a Scherk, Harald $u AMEOS Clinical Center Osnabrück, Osnabrück, Germany.
- 700 1_
- $a Schmauß, Max $u Department of Psychiatry and Psychotherapy, Bezirkskrankenhaus Augsburg, Augsburg, Germany.
- 700 1_
- $a Schofield, Peter R $u Neuroscience Research Australia, Sydney, NSW, Australia. School of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.
- 700 1_
- $a Schubert, K Oliver $u Discipline of Psychiatry, Royal Adelaide Hospital, Adelaide School of Medical Schooline, The University of Adelaide, Adelaide, SA, Australia.
- 700 1_
- $a Schulte, Eva C $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
- 700 1_
- $a Schulz, Sybille $u Department of Psychiatry, Klinikum Bremen-Ost, Bremen, Germany.
- 700 1_
- $a Senner, Fanny $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany. Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany.
- 700 1_
- $a Severino, Giovanni $u Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
- 700 1_
- $a Shekhtman, Tatyana $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a Shilling, Paul D $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a Simhandl, Christian $u Sigmund Freud University, Vienna, Austria. Bipolar Zentrum, Wiener Neustadt, Austria.
- 700 1_
- $a Slaney, Claire M $u Department of Psychiatry, Dalhousie University, Halifax, NS, Canada.
- 700 1_
- $a Spitzer, Carsten $u ASKLEPIOS Specialized Hospital Tiefenbrunn, Rosdorf, Germany.
- 700 1_
- $a Squassina, Alessio $u Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy.
- 700 1_
- $a Stamm, Thomas $u Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany. Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School Brandenburg, Neuruppin, Germany.
- 700 1_
- $a Stegmaier, Sophia $u Department of Psychiatry and Psychotherapy, Neurophysiology & Interventional Neuropsychiatry, University of Tübingen, Tübingen, Germany.
- 700 1_
- $a Stierl, Sebastian $u Psychiatric Hospital Lüneburg, Lüneburg, Germany.
- 700 1_
- $a Stopkova, Pavla $u National Institute of Mental Health, Klecany, Czech Republic.
- 700 1_
- $a Thiel, Andreas $u Department of Psychiatry and Psychotherapy, Agaplesion Diakonieklinikum, Rotenburg, Germany.
- 700 1_
- $a Tighe, Sarah K $u Psychiatry, University of Iowa, Iowa City, IA, USA.
- 700 1_
- $a Tortorella, Alfonso $u Department of Psychiatry, University of Perugia, Perugia, Italy.
- 700 1_
- $a Turecki, Gustavo $u Douglas Hospital, Verdun, QC, Canada.
- 700 1_
- $a Vieta, Eduard $u Bipolar Disorders Program, Institute of Neurosciences, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERSAM, Barcelona, Spain.
- 700 1_
- $a Veeh, Julia $u Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, University Hospital Frankfurt, Frankfurt, Germany.
- 700 1_
- $a von Hagen, Martin $u Clinic for Psychiatry and Psychotherapy, Clinical Center Werra-Meißner, Eschwege, Germany.
- 700 1_
- $a Wigand, Moritz E $u Department of Psychiatry II, Ulm University, Bezirkskrankenhaus Günzburg, Günzburg, Germany.
- 700 1_
- $a Wiltfang, Jens $u Department of Psychiatry and Psychotherapy, University Medical Center (UMG), Georg-August University Göttingen, Göttingen, Germany.
- 700 1_
- $a Witt, Stephanie $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Wright, Adam $u School of Psychiatry, University of New South Wales, Sydney, NSW, Australia. Black Dog Institute, Prince of Wales Hospital, Sydney, NSW, Australia.
- 700 1_
- $a Zandi, Peter P $u Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD, USA.
- 700 1_
- $a Zimmermann, Jörg $u Department of Psychiatry, Klinikum Bremen-Ost, Bremen, Germany.
- 700 1_
- $a Nöthen, Markus $u Institute of Human Genetics, University of Bonn and Department of Genomics, Life & Brain Center, Bonn, Germany.
- 700 1_
- $a Rietschel, Marcella $u Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany.
- 700 1_
- $a Schulze, Thomas G $u Institute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, LMU Munich, Munich, Germany.
- 773 0_
- $w MED00007648 $t Bipolar disorders $x 1399-5618 $g Roč. 21, č. 1 (2019), s. 68-75
- 856 41
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- 990 __
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- 999 __
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