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Method for identification of condition-associated public antigen receptor sequences

MV. Pogorelyy, AA. Minervina, DM. Chudakov, IZ. Mamedov, YB. Lebedev, T. Mora, AM. Walczak,

. 2018 ; 7 (-) : . [pub] 20180313

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19035356

Grantová podpora
724208 European Research Council - International

Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCR[Formula: see text] sequences .

Citace poskytuje Crossref.org

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$a Minervina, Anastasia A $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
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$a Chudakov, Dmitriy M $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia. Center for Data-Intensive Biomedicine and Biotechnology, Skolkovo Institute of Science and Technology, Moscow, Russia. Central European Institute of Technology, Brno, Czech republic.
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$a Mamedov, Ilgar Z $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia.
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$a Lebedev, Yuri B $u Department of Genomics of Adaptive Immunity, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia. Biological Faculty, Moscow State University, Moscow, Russia.
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$a Mora, Thierry $u Laboratoire de Physique Statistique, CNRS, Sorbonne University, Paris-Diderot University, École Normale Supérieure, Paris, France.
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$a Walczak, Aleksandra M $u Laboratoire de Physique Theorique, CNRS, Sorbonne University, École Normale Supérieure, Paris, France.
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