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Antibody Response to Toscana Virus and Sandfly Fever Sicilian Virus in Cats Naturally Exposed to Phlebotomine Sand Fly Bites in Portugal

A. Pereira, N. Ayhan, JM. Cristóvão, H. Vilhena, Â. Martins, P. Cachola, J. Henriques, M. Coimbra, A. Catarino, T. Lestinova, T. Spitzova, P. Volf, L. Campino, R. Charrel, C. Maia,

. 2019 ; 7 (9) : . [pub] 20190911

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19035696

Grantová podpora
SFRH/BD/116516/2016 Fundação para a Ciência e a Tecnologia, I.P
IF/01302/2015 Fundação para a Ciência e a Tecnologia, I.P.
UID/Multi/04413/2013 Global Health and Tropical Medicine Center
project CeRaViP (16_019/0000759) ERD funds
UNCE 204072 ERD funds
N.A. Bayer Animal Health, Germany

Phlebotomine sand fly-borne pathogens such as Leishmania spp. and phleboviruses are emerging threats to humans and animals worldwide. The aim of this work was to evaluate the exposure of cats from Portugal to Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV) and assess the associated risk factors. The possible association between exposure to Phlebotomus perniciosus saliva with TOSV and SFSV was also investigated. Out of 369 cats tested, 18 (4.9%, n = 365) were seropositive for TOSV, and eight (2.2%, n = 367) were seropositive for SFSV. Multivariate logistic regression analysis showed that cats presenting clinical signs that were compatible with leishmaniosis and antibodies to TOSV had a significantly higher risk of being SFSV seropositive. The presence of antibodies to sand fly-borne viruses in cats indicate that these animals are frequently exposed to sand flies and transmitted pathogens. Data suggest that cats can be used to qualitatively monitor human exposure to TOSV and SFSV in endemic areas. The clinical impact of SFSV in cats' health should be investigated. The identification of the sand fly species responsible for the circulation of TOSV and SFSV in nature and the evaluation of the vectorial competence of P. perniciosus to SFSV should also be addressed.

Citace poskytuje Crossref.org

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$a Pereira, André $u Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), 1349-008 Lisboa, Portugal. andrepereira.vet@gmail.com. Medical Parasitology Unit, IHMT-UNL, 1349-008 Lisboa, Portugal. andrepereira.vet@gmail.com.
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$a Phlebotomine sand fly-borne pathogens such as Leishmania spp. and phleboviruses are emerging threats to humans and animals worldwide. The aim of this work was to evaluate the exposure of cats from Portugal to Toscana virus (TOSV) and Sandfly Fever Sicilian virus (SFSV) and assess the associated risk factors. The possible association between exposure to Phlebotomus perniciosus saliva with TOSV and SFSV was also investigated. Out of 369 cats tested, 18 (4.9%, n = 365) were seropositive for TOSV, and eight (2.2%, n = 367) were seropositive for SFSV. Multivariate logistic regression analysis showed that cats presenting clinical signs that were compatible with leishmaniosis and antibodies to TOSV had a significantly higher risk of being SFSV seropositive. The presence of antibodies to sand fly-borne viruses in cats indicate that these animals are frequently exposed to sand flies and transmitted pathogens. Data suggest that cats can be used to qualitatively monitor human exposure to TOSV and SFSV in endemic areas. The clinical impact of SFSV in cats' health should be investigated. The identification of the sand fly species responsible for the circulation of TOSV and SFSV in nature and the evaluation of the vectorial competence of P. perniciosus to SFSV should also be addressed.
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$a Cristóvão, José Manuel $u Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), 1349-008 Lisboa, Portugal. jcristovao@ihmt.unl.pt. Medical Parasitology Unit, IHMT-UNL, 1349-008 Lisboa, Portugal. jcristovao@ihmt.unl.pt.
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$a Maia, Carla $u Global Health and Tropical Medicine (GHMT), Instituto de Higiene e Medicina Tropical (IHMT), Universidade Nova de Lisboa (UNL), 1349-008 Lisboa, Portugal. Carlamaia@ihmt.unl.pt. Medical Parasitology Unit, IHMT-UNL, 1349-008 Lisboa, Portugal. Carlamaia@ihmt.unl.pt.
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